Search Results - "Connolly, Derek L"

The additive prognostic value of coronary calcium score (CCS) to single photon emission computed tomography myocardial perfusion imaging (SPECT-MPI)-real world data from a single center by Sharma, Vinoda, Mughal, Lal, Dimitropoulos, Gerasimos, Sheikh, Awais, Griffin, Michael, Moss, Alexandra, Notghi, Alp, Pandit, Manish, Connolly, Derek L, Varma, Chetan, Kirchhof, Paulus

“…Single-photon emission computed tomography myocardial perfusion imaging [SPECT-MPI] is a functional test for coronary ischemia. We aimed to assess the additive…”
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Interactions Between Atrial Fibrillation and Natriuretic Peptide in Predicting Heart Failure Hospitalization or Cardiovascular Death by Brady, Paul F, Chua, Winnie, Nehaj, Frantisek, Connolly, Derek L, Khashaba, Alya, Purmah, Yanish J V, Ul-Qamar, Muhammad J, Thomas, Mark R, Varma, Chetan, Schnabel, Renate B, Zeller, Tanja, Fabritz, Larissa, Kirchhof, Paulus F

“…Background Natriuretic peptides are routinely quantified to diagnose heart failure (HF). Their concentrations are also elevated in atrial fibrillation (AF). To…”
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Evaluation of contemporary treatment of high- and very high-risk patients for the prevention of cardiovascular events in Europe – Methodology and rationale for the multinational observational SANTORINI study by Ray, Kausik K., Haq, Inaam, Bilitou, Aikaterini, Aguiar, Carlos, Arca, Marcello, Connolly, Derek L., Eriksson, Mats, Ferrières, Jean, Hildebrandt, Per, Laufs, Ulrich, Mostaza, Jose M., Nanchen, David, Rietzschel, Ernst, Strandberg, Timo, Toplak, Hermann, Visseren, Frank L.J., Catapano, Alberico L.

“…Clinical practice before 2019 suggests a substantial proportion of high and very high CV risk patients taking lipid-lowering therapy (LLT) would not achieve…”
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Combination lipid-lowering therapy as first-line strategy in very high-risk patients by Ray, Kausik K, Reeskamp, Laurens F, Laufs, Ulrich, Banach, Maciej, Mach, François, Tokgözoğlu, Lale S, Connolly, Derek L, Gerrits, Anja J, Stroes, Erik S G, Masana, Luis, Kastelein, John J P

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From clinical development to real-world outcomes with inclisiran by Connolly, Derek L, Sharma, Vinoda, Ray, Kausik K

“…Inclisiran is a small interfering RNA that blocks hepatocyte production of the PCSK9 (proprotein convertase subtilisin/kexin type 9) protein by specifically…”
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Treatment gaps in the implementation of LDL cholesterol control among high- and very high-risk patients in Europe between 2020 and 2021: the multinational observational SANTORINI study by Ray, Kausik K., Haq, Inaam, Bilitou, Aikaterini, Manu, Marius C., Burden, Annie, Aguiar, Carlos, Arca, Marcello, Connolly, Derek L., Eriksson, Mats, Ferrières, Jean, Laufs, Ulrich, Mostaza, Jose M., Nanchen, David, Rietzschel, Ernst, Strandberg, Timo, Toplak, Hermann, Visseren, Frank L.J., Catapano, Alberico L.

“…European data pre-2019 suggest statin monotherapy is the most common approach to lipid management for preventing cardiovascular (CV) events, resulting in only…”
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Rivaroxaban Plus Aspirin Versus Aspirin Alone in Patients With Prior Percutaneous Coronary Intervention (COMPASS-PCI) by Bainey, Kevin R., Welsh, Robert C., Connolly, Stuart J., Marsden, Tamara, Bosch, Jackie, Fox, Keith A.A., Steg, P. Gabriel, Vinereanu, Dragos, Connolly, Derek L., Berkowitz, Scott D., Foody, JoAnne M., Probstfield, Jeffrey L., Branch, Kelley R., Lewis, Basil S., Diaz, Rafael, Muehlhofer, Eva, Widimsky, Petr, Yusuf, Salim, Eikelboom, John W., Bhatt, Deepak L.

“…The COMPASS trial (Cardiovascular Outcomes for People using Anticoagulation Strategies) demonstrated that dual pathway inhibition (DPI) with rivaroxaban 2.5 mg…”
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Statin Prescription is Essential in Peripheral Vascular Disease by Leyon, Joe J., MBBS, MRCP, Jaiveer, Saraswathy, MBBS, MRCP, Connolly, Derek L., BSc (Hons), MBChB(Edin), PhD, FRCP, Babu, Suresh, MBBS, DMRD, FRCP, FRCR

“…Hypercholesterolemia is an important and easily modifiable risk factor for peripheral arterial disease (PAD), but is frequently not adequately addressed by…”
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Amplified inhibition of atherosclerotic plaque-induced platelet activation by glenzocimab with dual antiplatelet therapy by Alenazy, Fawaz O., Harbi, Maan H., Kavanagh, Dean P., Price, Joshua, Brady, Paul, Hargreaves, Oscar, Harrison, Paul, Slater, Alexandre, Tiwari, Alok, Nicolson, Phillip L.R., Connolly, Derek L., Kirchhof, Paulus, Kalia, Neena, Jandrot-Perrus, Martine, Mangin, Pierre H., Watson, Steve P., Thomas, Mark R.

“…Aspirin and platelet P2Y12 inhibitors, such as ticagrelor, suboptimally inhibit microvascular thrombosis during ST-elevation myocardial infarction…”
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Considerations and treatment options for patients with comorbid atrial fibrillation and diabetes mellitus by Moss, Alexandra Sophie, Dimitropoulos, Gerasimos, Connolly, Derek L, Lip, Gregory Y H

“…Atrial fibrillation (AF) and diabetes mellitus (DM) are common worldwide and their incidence is increasing, representing a significant public health and…”
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Re: ‘Avoidance hierarchies and preferences for anticoagulation—semi-qualitative analysis of older patients’ views about stroke prevention and the use of warfarin by Choudhury, Anirban, Chowdhury, Sharmistha Roy, Connolly, Derek L.

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Pushing the envelope too far? by Connolly, Derek L., Lip, Greg Y.H., Lo, Ted S.N.

“…Overall major adverse cardiac events were 2.4%, with a 0.6% incidence (5 cases) of urgent coronary artery bypass grafting (UCABG) and a mortality of 0.5% (4…”
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Statins and rheumatoid arthritis by Bhatia, Gurbir S, Sosin, Michael D, Connolly, Derek L, Davis, Russell C

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Aquaporin-1 is expressed by vascular smooth muscle cells and mediates rapid water transport across vascular cell membranes by Shanahan, C M, Connolly, D L, Tyson, K L, Cary, N R, Osbourn, J K, Agre, P, Weissberg, P L

“…The aquaporins are a rapidly expanding family of highly conserved proteins which function as transmembrane water channels. We have previously shown that the…”
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A randomized trial of aspirin on the risk of embolic events in patients with infective endocarditis by Connolly, Derek L, Choudhury, Anirban, Davis, Russell C, Lip, Greg Y.H

“…[...]patients with infective endocarditis presenting with emboli have been documented to have excessive bleeding when given high-dose antiplatelet and…”
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Hibernating myocardium in heart failure by Bhatia, Gurbir, Sosin, Michael, Leahy, John F, Connolly, Derek L, Davis, Russel C, Lip, Gregory Y H

“…Ischemic left ventricular systolic dysfunction may result from myocardial necrosis or from hypocontractile areas of viable myocardium. In some cases, recovery…”
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A ‘Reveal’ing Diagnosis by OSMAN, FAIZEL, AHMAD, RAJAI A., DAVIS, RUSSELL C., CONNOLLY, DEREK L., CADIGAN, PATRICK J.

“…The present case report describes a 54‐year‐old woman with recurrent syncope of undetermined etiology. Despite several cardiological and neurological…”
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Inflammatory risk and cardiovascular events in patients without obstructive coronary artery disease: the ORFAN multicentre, longitudinal cohort study by Chan, Kenneth, Wahome, Elizabeth, Tsiachristas, Apostolos, Antonopoulos, Alexios S, Kingham, Lucy, West, Henry, Volpe, Lucrezia, Mavrogiannis, Michail C, Nicol, Edward, Mittal, Tarun K, Halborg, Thomas, Kotronias, Rafail A, Adlam, David, Modi, Bhavik, Rodrigues, Jonathan, Screaton, Nicholas, Kardos, Attila, Greenwood, John P, Sabharwal, Nikant, De Maria, Giovanni Luigi, Munir, Shahzad, Sohan, Yogesh, Tomlins, Pete, Siddique, Muhammad, Kelion, Andrew, Pugliese, Francesca, Petersen, Steffen E, Blankstein, Ron, Desai, Milind, Gersh, Bernard J, Libby, Peter, Neubauer, Stefan, Channon, Keith M, Antoniades, Charalambos, Denton, Jon, Farral, Robyn, Taylor, Carolyn, Kasongo, Mary, Anthony, Susan, Banning, Adrian, Xie, Cheng, Kharbanda, Rajesh K, Halborg, Thomas, Syed, Nigar, Fry, Sam, Mathers, Chris, Rose, Anne, Hudson, George, Bajaj, Amrita, Das, Intrajeet, Deshpande, Aparna, Rao, Praveen, Lawday, Dan, Mirsadraee, Saeed, Hudson, Benjamin, Berry, Colin, Maurovich-Horvat, Pál, He, Guo-Wei, Lin, Wen-Hua, Fan, Li-Juan, Kondo, Hidekazu, Dai, Neng, Ge, Junbo, Koo, Bon-Kwon, Guglielmo, Marco, Pontone, Gianluca, Huck, Daniel, Benedek, Theodora, Rajani, Ronak, Vilic, Dijana, Aljazzaf, Haleema, Mun, Mak S, Benedetti, Giulia, Preston, Rebecca L, Raisi-Estabragh, Zahra, Connolly, Derek L, Grenfell, Rebecca, Bradlow, William, Serfaty, Fabiano, Neves, Mario FT, Newby, David E, Dweck, Marc R, Hatem, Stéphane, Redheuil, Alban, Benetos, Georgios, Beer, Meinrad, Granillo, Gastón AR, Selvanayagam, Joseph, De Bosscher, Ruben, Tavildari, Alain, Figtree, Gemma, Danad, Ibrahim, Shantouf, Ronney, Kietselaer, Bas, Tousoulis, Dimitris, Dangas, George, Mehta, Nehal N, Kontanidis, Christos, Kunadian, Vijay, Fairbairn, Timothy A

“…Coronary computed tomography angiography (CCTA) is the first line investigation for chest pain, and it is used to guide revascularisation. However, the…”
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Assessing opinion on lower LDL-cholesterol lowering, and the role of newer lipid-reducing treatment options by Connolly, Derek L, Zaman, Azfar, Capps, Nigel E, Bain, Steve C, Fernando, Kevin

“…While statins are the gold standard for lipid-lowering therapies, newer therapies, such as PCSK9 inhibitors, have also demonstrated low-density lipoprotein…”
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Use of combination therapy is associated with improved LDL cholesterol management: 1-year follow-up results from the European observational SANTORINI study by Ray, Kausik K, Aguiar, Carlos, Arca, Marcello, Connolly, Derek L, Eriksson, Mats, Ferrières, Jean, Laufs, Ulrich, Mostaza, Jose M, Nanchen, David, Bardet, Aurélie, Lamparter, Mathias, Chhabra, Richa, Soronen, Jarkko, Rietzschel, Ernst, Strandberg, Timo, Toplak, Hermann, Visseren, Frank L J, Catapano, Alberico L

“…Abstract Aims To assess whether implementation of the 2019 European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) dyslipidaemia guidelines…”
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