Search Results - "Connolly, C N"

Ketone body β-hydroxybutyrate (BHB) preserves mitochondrial bioenergetics by Llorente-Folch, I., Düssmann, H., Watters, O., Connolly, N. M. C., Prehn, Jochen H. M.

“…The ketogenic diet is an emerging therapeutic approach for refractory epilepsy, as well as certain rare and neurodegenerative disorders. The main ketone body,…”
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The Cys-loop superfamily of ligand-gated ion channels: the impact of receptor structure on function by Connolly, C N, Wafford, K A

“…The Cys-loop receptors constitute an important superfamily of LGICs (ligand-gated ion channels) comprising receptors for acetylcholine, 5-HT3…”
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Magnitude of the inflammatory response to cardiopulmonary bypass and its relation to adverse clinical outcomes by Holmes, 4th, J H, Connolly, N C, Paull, D L, Hill, M E, Guyton, S W, Ziegler, S F, Hall, R A

“…Cardiopulmonary bypass (CPB) induces an inflammatory response believed to contribute to postoperative morbidity. We hypothesized that the magnitude of the…”
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Two-step activation of FOXO3 by AMPK generates a coherent feed-forward loop determining excitotoxic cell fate by Davila, D, Connolly, N M C, Bonner, H, Weisová, P, Dussmann, H, Concannon, C G, Huber, H J, Prehn, J H M

“…Cerebral ischemia and excitotoxic injury induce transient or permanent bioenergetic failure, and may result in neuronal apoptosis or necrosis. We have…”
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In vitro and in vivo protein sampling by combined microdialysis and ultrafiltration by Rosenbloom, A.J., Ferris, R., Sipe, D.M., Riddler, S.A., Connolly, N.C., Abe, K., Whiteside, T.L.

“…Cytokines, chemokines and growth factors regulate inflammation, resistance to infection and tissue repair. Understanding their function within tissues is a…”
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Multiple assembly signals in gamma-aminobutyric acid (type A) receptor subunits combine to drive receptor construction and composition by Bollan, K, Robertson, L A, Tang, H, Connolly, C N

“…Mammalian gamma-aminobutyric acid type A (GABAA) receptors are constructed from a large repertoire of subunits (alpha1-alpha6, beta1-beta3, gamma1-gamma3,…”
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Trafficking of 5-HT(3) and GABA(A) receptors (Review) by Connolly, C N

“…The 5-HT(3) and GABA(A) receptors are members of the Cys-loop family of neurotransmitter-gated ion channels that also include receptors for glycine and…”
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Subcellular Localization of γ -Aminobutyric Acid Type A Receptors is Determined by Receptor β Subunits by Connolly, Christopher N., Julian R. A. Wooltorton, Smart, Trevor G., Moss, Stephen J.

“…γ -aminobutyric acid type A (GABAA receptors are the major sites of fast synaptic inhibition in the brain. They are constructed from four subunit classes with…”
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Pilot study of a community pharmacist led program to treat hepatitis C virus among people who inject drugs by Tsui, J.I., Gojic, A.J., Pierce, K.A., Tung, E.L., Connolly, N.C., Radick, A.C., Hunt, R.R., Sandvold, R., Taber, K., Ninburg, M., Kubiniec, R.H., Scott, J.D., Hansen, R.N., Stekler, J.D., Austin, E.J., Williams, E.C., Glick, S.N.

“…•A collaborative, pharmacist-led model treated hep C among people who use drugs (PWID).•Over half started hep C meds; majority of those who completed meds/labs…”
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Proton sensitivity of the GABA(A) receptor is associated with the receptor subunit composition by Krishek, B J, Amato, A, Connolly, C N, Moss, S J, Smart, T G

“…1. Modulation of GABA(A) receptors by external H(+) was examined in cultured rat sympathetic neurones, and in Xenopus laevis oocytes and human embryonic kidney…”
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The role of GABAA receptor biogenesis, structure and function in epilepsy by Mizielinska, S, Greenwood, S, Connolly, C N

“…Maintaining the correct balance in neuronal activation is of paramount importance to normal brain function. Imbalances due to changes in excitation or…”
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Single-cell imaging of bioenergetic responses to neuronal excitotoxicity and oxygen and glucose deprivation by Connolly, Niamh M C, Düssmann, Heiko, Anilkumar, Ujval, Huber, Heinrich J, Prehn, Jochen H M

“…Excitotoxicity is a condition occurring during cerebral ischemia, seizures, and chronic neurodegeneration. It is characterized by overactivation of glutamate…”
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Cell surface stability of gamma-aminobutyric acid type A receptors. Dependence on protein kinase C activity and subunit composition by Connolly, C N, Kittler, J T, Thomas, P, Uren, J M, Brandon, N J, Smart, T G, Moss, S J

“…Type A gamma-aminobutyric acid receptors (GABA(A)), the major sites of fast synaptic inhibition in the brain, are believed to be composed predominantly of…”
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Assembly and Cell Surface Expression of Heteromeric and Homomeric γ-Aminobutyric Acid Type A Receptors (∗) by Connolly, Christopher N., Krishek, Belinda J., McDonald, Bernard J., Smart, Trevor G., Moss, Stephen J.

“…The ability of differing subunit combinations of γ-aminobutyric acid type A (GABAA) receptors produced from murine α1, β2, and γ2L subunits to form functional…”
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Identification of amino acid residues within GABA(A) receptor beta subunits that mediate both homomeric and heteromeric receptor expression by Taylor, P M, Thomas, P, Gorrie, G H, Connolly, C N, Smart, T G, Moss, S J

“…GABA(A) receptors are believed to be heteropentamers that can be constructed from six subunit classes: alpha(1-6), beta(1-4), gamma(1-3), delta, epsilon, and…”
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Cell Surface Expression of 5-Hydroxytryptamine Type 3 Receptors Is Controlled by an Endoplasmic Reticulum Retention Signal by Boyd, Gary W., Doward, Anne I., Kirkness, Ewen F., Millar, Neil S., Connolly, Christopher N.

“…Two subunits of the 5-hydroxytryptamine type 3 (5-HT3) have been identified (5-HT3A and 5-HT3B) that assemble into homomeric (5-HT3A) and heteromeric…”
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Assembly and Cell Surface Expression of Homomeric and Heteromeric 5-HT3 Receptors: The Role of Oligomerization and Chaperone Proteins by Boyd, Gary W., Low, Pamela, Dunlop, James I., Robertson, Laura A., Vardy, Audrey, Lambert, Jeremy J., Peters, John A., Connolly, Christopher N.

“…The ability of differing subunit combinations of 5-HT3 receptors to form functional cell surface receptors was analyzed by a variety of approaches. The results…”
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Newly Synthesized Transferrin Receptors Can Be Detected in the Endosome before They Appear on the Cell Surface by Futter, Clare E., Connolly, Christopher N., Cutler, Daniel F., Hopkins, Colin R.

“…It is well established that a proportion of newly synthesized lysosomal enzymes and class II major histocompatibility complex antigens are delivered directly…”
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Identification of residues within GABA(A) receptor alpha subunits that mediate specific assembly with receptor beta subunits by Taylor, P M, Connolly, C N, Kittler, J T, Gorrie, G H, Hosie, A, Smart, T G, Moss, S J

“…GABA(A) receptors can be constructed from a range of differing subunit isoforms: alpha, beta, gamma, delta, and epsilon. Expression studies have revealed that…”
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Proinflammatory cytokines in HIV disease-a review and rationale for new therapeutic approaches by Connolly, Nancy C, Riddler, Sharon A, Rinaldo, Charles R

“…Antiretroviral drugs currently in use for treating HIV-1 infection are very effective at maintaining low viral loads and clinical stability, but have been…”
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