Search Results - "Connolly, Adam"

Virtual electrodes around anatomical structures and their roles in defibrillation by Connolly, Adam, Vigmond, Edward, Bishop, Martin

“…Virtual electrodes from structural/conductivity heterogeneities are known to elicit wavefront propagation, upon field-stimulation, and are thought to be…”
Get full text

OpenEP: A Cross-Platform Electroanatomic Mapping Data Format and Analysis Platform for Electrophysiology Research by Williams, Steven E, Roney, Caroline H, Connolly, Adam, Sim, Iain, Whitaker, John, O'Hare, Daniel, Kotadia, Irum, O'Neill, Louisa, Corrado, Cesare, Bishop, Martin, Niederer, Steven A, Wright, Matt, O'Neill, Mark, Linton, Nick W F

“…Electroanatomic mapping systems are used to support electrophysiology research. Data exported from these systems is stored in proprietary formats which are…”
Get full text

Computational Representations of Myocardial Infarct Scars and Implications for Arrhythmogenesis by Connolly, Adam J., Bishop, Martin J.

“…Image-based computational modeling is becoming an increasingly used clinical tool to provide insight into the mechanisms of reentrant arrhythmias. In the…”
Get full text

Structural heterogeneity modulates effective refractory period: a mechanism of focal arrhythmia initiation by Bishop, Martin J, Connolly, Adam, Plank, Gernot

“…Reductions in electrotonic loading around regions of structural and electrophysiological heterogeneity may facilitate capture of focal triggered activity,…”
Get full text

Improved co-registration of ex-vivo and in-vivo cardiovascular magnetic resonance images using heart-specific flexible 3D printed acrylic scaffold combined with non-rigid registration by Whitaker, John, Neji, Radhouene, Byrne, Nicholas, Puyol-Antón, Esther, Mukherjee, Rahul K, Williams, Steven E, Chubb, Henry, O'Neill, Louisa, Razeghi, Orod, Connolly, Adam, Rhode, Kawal, Niederer, Steven, King, Andrew, Tschabrunn, Cory, Anter, Elad, Nezafat, Reza, Bishop, Martin J, O'Neill, Mark, Razavi, Reza, Roujol, Sébastien

“…Ex-vivo cardiovascular magnetic resonance (CMR) imaging has played an important role in the validation of in-vivo CMR characterization of pathological…”
Get full text

Bidomain Predictions of Virtual Electrode-Induced Make and Break Excitations around Blood Vessels by Connolly, Adam J, Vigmond, Edward, Bishop, Martin J

“…Virtual electrodes formed by field stimulation during defibrillation of cardiac tissue play an important role in eliciting activations. It has been suggested…”
Get full text

Late Gadolinium Enhancement Cardiovascular Magnetic Resonance Assessment of Substrate for Ventricular Tachycardia With Hemodynamic Compromise by Whitaker, John, Neji, Radhouene, Kim, Steven, Connolly, Adam, Aubriot, Thierry, Calvo, Justo Juliá, Karim, Rashed, Roney, Caroline H, Murfin, Brendan, Richardson, Carla, Morgan, Stephen, Ismail, Tevfik F, Harrison, James, de Vos, Judith, Aalders, Maurice C G, Williams, Steven E, Mukherjee, Rahul, O'Neill, Louisa, Chubb, Henry, Tschabrunn, Cory, Anter, Elad, Camporota, Luigi, Niederer, Steven, Roujol, Sébastien, Bishop, Martin J, Wright, Matthew, Silberbauer, John, Razavi, Reza, O'Neill, Mark

“…The majority of data regarding tissue substrate for post myocardial infarction (MI) VT has been collected during hemodynamically tolerated VT, which may be…”
Get full text

Normal interventricular differences in tissue architecture underlie right ventricular susceptibility to conduction abnormalities in a mouse model of Brugada syndrome by Kelly, Allen, Salerno, Simona, Connolly, Adam, Bishop, Martin, Charpentier, Flavien, Stølen, Tomas, Smith, Godfrey L

“…Abstract Aims Loss-of-function of the cardiac sodium channel NaV1.5 is a common feature of Brugada syndrome. Arrhythmias arise preferentially from the right…”
Get full text

Moderate but not severe hypothermia causes pro-arrhythmic changes in cardiac electrophysiology by Dietrichs, Erik S, McGlynn, Karen, Allan, Andrew, Connolly, Adam, Bishop, Martin, Burton, Francis, Kettlewell, Sarah, Myles, Rachel, Tveita, Torkjel, Smith, Godfrey L

“…Abstract Aims Treatment of arrhythmias evoked by hypothermia/rewarming remains challenging, and the underlying mechanisms are unclear. This in vitro…”
Get full text

PO-618-02 AN AUTOMATED ALGORITHM TO ENHANCE ANTI-TACHYCARDIA PACING EFFICACY BY ATTENUATING RE-INITIATION OF VENTRICULAR TACHYCARDIA by Qian, Shuang, Connolly, Adam, Costa, Caroline Mendonca, Campos, Fernando Otaviano, Rodero, Cristobal, Whitaker, John, Rinaldi, Christopher A., Bishop, Martin J.

Get full text

Optimization of anti-tachycardia pacing efficacy through scar-specific delivery and minimization of re-initiation: a virtual study on a cohort of infarcted porcine hearts by Qian, Shuang, Connolly, Adam, Mendonca-Costa, Caroline, Campos, Fernando, Rodero, Cristobal, Whitaker, John, Rinaldi, Christopher A, Bishop, Martin J

“…Anti-tachycardia pacing (ATP) is a reliable electrotherapy to painlessly terminate ventricular tachycardia (VT). However, ATP is often ineffective,…”
Get full text

Conceptual Intra-Cardiac Electrode Configurations That Facilitate Directional Cardiac Stimulation for Optimal Electrotherapy by Connolly, Adam, Williams, Steven, Rhode, Kawal, Rinaldi, Christopher A., Bishop, Martin J.

“…Objective: Electrotherapy remains the most effective direct therapy against lethal cardiac arrhythmias. When an arrhythmic event is sensed, either strong…”
Get full text

Ventricular Endocardial Tissue Geometry Affects Stimulus Threshold and Effective Refractory Period by Connolly, Adam, Kelly, Allen, Campos, Fernando O., Myles, Rachel, Smith, Godfrey, Bishop, Martin J.

“…Background: Understanding the biophysical processes by which electrical stimuli applied to cardiac tissue may result in local activation is important in both…”
Get full text

An in-silico assessment of efficacy of two novel intra-cardiac electrode configurations versus traditional anti-tachycardia pacing therapy for terminating sustained ventricular tachycardia by Qian, Shuang, Connolly, Adam, Mendonca-Costa, Caroline, Campos, Fernando, Williams, Steven E., Whitaker, John, Rinaldi, Christopher A., Bishop, Martin J.

“…The implanted cardioverter defibrillator (ICD) is an effective direct therapy for the treatment of cardiac arrhythmias, including ventricular tachycardia (VT)…”
Get full text

Local Gradients in Electrotonic Loading Modulate the Local Effective Refractory Period: Implications for Arrhythmogenesis in the Infarct Border Zone by Connolly, Adam, Trew, Mark L., Smaill, Bruce H., Plank, Gernot, Bishop, Martin J.

“…Ectopic electrical activity that originates in the peri-infarct region can give rise to potentially lethal re-entrant arrhythmias. The spatial variation in…”
Get full text

Generation of a cohort of whole-torso cardiac models for assessing the utility of a novel computed shock vector efficiency metric for ICD optimisation by Plancke, Anne-Marie, Connolly, Adam, Gemmell, Philip M., Neic, Aurel, McSpadden, Luke C., Whitaker, John, O'Neill, Mark, Rinaldi, Christopher A., Rajani, Ronak, Niederer, Steven A., Plank, Gernot, Bishop, Martin J.

“…Implanted cardiac defibrillators (ICDs) seek to automatically detect and terminate potentially lethal ventricular arrhythmias by applying strong internal…”
Get full text

Highly trabeculated structure of the human endocardium underlies asymmetrical response to low-energy monophasic shocks by Connolly, Adam, Robson, Matthew D, Schneider, Jürgen, Burton, Rebecca, Plank, Gernot, Bishop, Martin J

“…Novel low-energy defibrillation therapies are thought to be driven by virtual-electrodes (VEs), due to the interaction of applied monophasic electric shocks…”
Get more information

Comparing quantum and classical Monte Carlo algorithms for estimating Betti numbers of clique complexes by Akhalwaya, Ismail Yunus, Bhayat, Ahmed, Connolly, Adam, Herbert, Steven, Horesh, Lior, Sorci, Julien, Ubaru, Shashanka

“…Several quantum and classical Monte Carlo algorithms for Betti Number Estimation (BNE) on clique complexes have recently been proposed, though it is unclear…”
Get full text

Investigation of Low-Voltage Defibrillation by Standing Waves in Human Ventricular Tissue Models by Georgiev, Nikolay, Connolly, Adam, Bishop, Martin, Aslanidi, Oleg

“…Ventricular fibrillation (VF) is one of the main causes of sudden cardiac death. Strong electric shocks remain the only reliable mechanism for successful…”
Get full text

A Modular Engine for Quantum Monte Carlo Integration by Akhalwaya, Ismail Yunus, Connolly, Adam, Guichard, Roland, Herbert, Steven, Kargi, Cahit, Krajenbrink, Alexandre, Lubasch, Michael, Keever, Conor Mc, Sorci, Julien, Spranger, Michael, Williams, Ifan

“…We present the Quantum Monte Carlo Integration (QMCI) engine developed by Quantinuum. It is a quantum computational tool for evaluating multi-dimensional…”
Get full text