Search Results - "Connis, Nick"

Nelfinavir Inhibits the Growth of Small-cell Lung Cancer Cells and Patient-derived Xenograft Tumors by Kawabata, Shigeru, Connis, Nick, Gills, Joell J, Hann, Christine L, Dennis, Phillip A

“…Small-cell lung cancer (SCLC) is aggressive and confers poor prognosis. Although SCLC shows more response to chemotherapy than other types of lung cancer, it…”
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Rapamycin Rescues ABT-737 Efficacy in Small Cell Lung Cancer by GARDNER, Eric E, CONNIS, Nick, POIRIER, John T, COPE, Leslie, DOBROMILSKAYA, Irina, GALLIA, Gary L, RUDIN, Charles M, HANN, Christine L

“…Overexpression of the antiapoptotic protein Bcl-2 is observed in the majority of small cell lung cancer (SCLC) cases and is associated with resistance to…”
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Erlotinib inhibits growth of a patient-derived chordoma xenograft by Siu, I-Mei, Ruzevick, Jacob, Zhao, Qi, Connis, Nick, Jiao, Yuchen, Bettegowda, Chetan, Xia, Xuewei, Burger, Peter C, Hann, Christine L, Gallia, Gary L

“…Chordomas are rare primary bone tumors that occur along the neuraxis. Primary treatment is surgery, often followed by radiotherapy. Treatment options for…”
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Co-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice by Khan, Sajid, Kellish, Patrick, Connis, Nick, Thummuri, Dinesh, Wiegand, Janet, Zhang, Peiyi, Zhang, Xuan, Budamagunta, Vivekananda, Hua, Nan, Yang, Yang, De, Umasankar, Jin, Lingtao, Zhang, Weizhou, Zheng, Guangrong, Hromas, Robert, Hann, Christine, Zajac-Kaye, Maria, Kaye, Frederic J., Zhou, Daohong

“…Small-cell lung cancer (SCLC) is an aggressive malignancy with limited therapeutic options. The dismal prognosis in SCLC is in part associated with an…”
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Bisphosphonamidate clodronate prodrug exhibits selective cytotoxic activity against melanoma cell lines by Webster, Marie R, Kamat, Chandrashekhar, Connis, Nick, Zhao, Ming, Weeraratna, Ashani T, Rudek, Michelle A, Hann, Christine L, Freel Meyers, Caren L

“…Bisphosphonates are used clinically to treat disorders of calcium metabolism and malignant bone disease and are known to inhibit cancer cell growth, adhesion,…”
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DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2 by Poirier, J T, Gardner, E E, Connis, N, Moreira, A L, de Stanchina, E, Hann, C L, Rudin, C M

“…Small cell lung cancer (SCLC) is an aggressive malignancy characterized by early metastasis, rapid development of resistance to chemotherapy and genetic…”
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Abstract PR-008: Identification and characterization of the molecular mechanisms of SCLC chemo-radiation resistance by Carrieri, Francesca Anna, Connis, Nick, Grasset, Eloise, Luidy-Imada, Eddie, Ewald, Andrew, Marchionni, Luigi, Hann, Christine, Tran, Phuoc T.

“…Abstract Small cell lung cancer (SCLC) is among the most aggressive form of lung malignancies and accounts for 15-20% of all lung cancers. It has the tendency…”
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AZD8055 enhances in vivo efficacy of afatinib in chordomas by Zhao, Tianna, Siu, I‐Mei, Williamson, Tara, Zhang, Haoyu, Ji, Chenchen, Burger, Peter C, Connis, Nick, Ruzevick, Jacob, Xia, Menghang, Cottone, Lucia, Flanagan, Adrienne M, Hann, Christine L, Gallia, Gary L

“…Chordomas are primary bone tumors that arise in the cranial base, mobile spine, and sacrococcygeal region, affecting patients of all ages. Currently, there are…”
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Griseofulvin Radiosensitizes Non-Small Cell Lung Cancer Cells and Activates cGAS by Wang, Xing, Raman, Natasha, Lemtiri-Chlieh, Ghali, Chang, Jinhee, Jagtap, Shreya, Chowdhury, Dipanwita Dutta, Ballew, Matthew, Carrieri, Francesca Anna, Nguyen, Triet, Nugent, Katriana, Peck, Travis, Levine, Michelle S, Chan, Aaron, Lam, Christine, Malek, Reem, Hoang, Tung, Phillips, Ryan, Cheng, ZhuoAn, Taparra, Kekoa, Connis, Nick, Hann, Christine L, Holland, Andrew, Tran, Phuoc T, Lafargue, Audrey, Wang, Hailun

“…Extra copies of centrosomes are frequently observed in cancer cells. To survive and proliferate, cancer cells have developed strategies to cluster…”
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Abstract 3926: Establishment of patient-derived organoids as ex vivo tool to characterize the molecular mechanisms of SCLC chemo-radiation resistance by Carrieri, Francesca A., Connis, Nick, Grasset, Eloise M., Chan, Isaac S., Luidy-Imada, Eddie, Lam, Christine, Wang, Hailun, Ewald, Andrew J., Marchionni, Luigi, Hann, Christine L., Tran, Phuoc T.

“…Abstract Small cell lung cancer (SCLC) is the most aggressive form of lung malignancies and accounts for 15-20% of all lung cancers. It has the tendency to…”
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Abstract 1125: TNIK induced chemoradiation resistance in small cell lung cancer by Chowdhury, Dipanwita Dutta, Imada, Eddie, Connis, Nick, Nguyen, Triet, Chang, Jinhee, Council, Danielle, Lafargue, Audrey, Rezaee, Mohammad, Tran, Phuoc T., Marchionni, Luigi, Hann, Christine L.

“…Abstract Chemoradiation (CRT) is the standard first-line therapy for limited stage small cell lung cancer (LS-SCLC), which is characterized by early…”
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Abstract 684: Nelfinavir inhibits the growth of small cell lung cancer cells and patient-derived xenograft tumors by Kawabata, Shigeru, Connis, Nick, Zhang, Chunyu, Gills, Joell J., Hann, Christine L., Dennis, Phillip A.

“…Abstract Small cell lung cancer (SCLC) is an aggressive lung cancer with a poor prognosis that is characterized by frequent metastasis at the time of…”
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Poly(β-amino ester) nanoparticle delivery of TP53 has activity against small cell lung cancer in vitro and in vivo by Kamat, Chandrashekhar D, Shmueli, Ron B, Connis, Nick, Rudin, Charles M, Green, Jordan J, Hann, Christine L

“…Small cell lung cancer (SCLC) is an aggressive disease with one of the highest case-fatality rates among cancer. The recommended therapy for SCLCs has not…”
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Abstract 2818: Investigating TNIK as a radiosensitizing target in lung squamous cell carcinoma by Nguyen, Triet M., Lafargue, Audrey M., Carrieri, Francesca A., Connis, Nick, Chang, Jinhee, Jagtap, Shreya, Torres-Ayuso, Pedro, Brognard, John, Hann, Christine L., Tran, Phuoc T.

“…Abstract In this study, we investigated the potential of TNIK inhibition as a radiosensitizing strategy in lung squamous cell carcinoma (LSCC). LSCC is a type…”
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Abstract 2818: Investigating the role of TNIK in the pathogenesis of lung squamous cell carcinoma by Chang, Jin Hee, Chowdhury, Dipanwita Dutta, Council, Danielle N., Nguyen, Triet, Jagtap, Shreya, Chan, Aaron, Khan, Muhammad Ajmal, Connis, Nick, Torres-Ayuso, Pedro, Brognard, John, Rezaee, Moahmmad, Lafargue, Audrey, Hann, Christine, Tran, Phuoc T.

“…Abstract Lung squamous cell carcinoma (LSCC) is the second most prevalent type of lung cancer with no FDA-approved targeted therapies. Platinum-based…”
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Co-targeting BCL-X L and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice by Khan, Sajid, Kellish, Patrick, Connis, Nick, Thummuri, Dinesh, Wiegand, Janet, Zhang, Peiyi, Zhang, Xuan, Budamagunta, Vivekananda, Hua, Nan, Yang, Yang, De, Umasankar, Jin, Lingtao, Zhang, Weizhou, Zheng, Guangrong, Hromas, Robert, Hann, Christine, Zajac-Kaye, Maria, Kaye, Frederic J, Zhou, Daohong

“…Small-cell lung cancer (SCLC) is an aggressive malignancy with limited therapeutic options. The dismal prognosis in SCLC is in part associated with an…”
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Regulation of RhoB Gene Expression during Tumorigenesis and Aging Process and Its Potential Applications in These Processes by Gutierrez, Eutiquio, Cahatol, Ian, Bailey, Cedric A R, Lafargue, Audrey, Zhang, Naming, Song, Ying, Tian, Hongwei, Zhang, Yizhi, Chan, Ryan, Gu, Kevin, Zhang, Angel C C, Tang, James, Liu, Chunshui, Connis, Nick, Dennis, Phillip, Zhang, Chunyu

“…RhoB, a member of the Ras homolog gene family and GTPase, regulates intracellular signaling pathways by interfacing with epidermal growth factor receptor…”
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Abstract 1438: Investigating the roles of EMT in small cell lung cancer tumorigenesis and chemoradiation response by Nguyen, Triet, Chang, Jinhee, Gabrielson, Kathleen, Shetty, Amol, Song, Yang, Lafargue, Audrey, Jagtap, Shreya, Council, Danielle, Chan, Aaron, Chowdhury, Dipanwita Dutta, Khan, Muhammad Ajmal, Connis, Nick, Carrieri, Francesca, Imada, Eddie, Sforza, Daniel, Gardner, Eric, McFarland, Christopher, Marchionni, Luigi, Rezaee, Mohammad, Hann, Christine, Tran, Phuoc

“…Abstract In this study, we investigated the contributions of the epithelial-mesenchymal transition (EMT) program to small cell lung cancer (SCLC) tumorigenesis…”
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Abstract 2968: TWIST1-induced suppression of oncogene-induced senescence in non-small cell lung cancer requires the transactivation domain of TWIST1 by Lafargue, Audrey M., Wang, Hailun, Chettiar, Sivarajan T., Gajula, Rajendra P., Shetty, Amol C., Song, Yang, Simons, Brian W., Nguyen, Triet, Lam, Christine, Carrieri, Francesca A., Smack, Caleb, Connis, Nick, Chowdhury, Dipanwita Dutta, Chang, Jinhee, Council, Danielle, Nugent, Katriana, Siddiqui, Ismaeel, Taparra, Kekoa, Rezaee, Mohammad, Zachara, Natasha, Morris, Zachary S., McFarland, Christopher, Abdulkadir, Sarki Abba, Hann, Christine L., Tran, Phuoc T.

“…Abstract Non-small cell lung carcinoma (NSCLC) is a major cause of cancer mortality. High expression of the epithelial-to-mesenchymal transition transcription…”
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Characterizing the behavioral effects of nerve agent-induced seizure activity in rats: Increased startle reactivity and perseverative behavior by Langston, Jeffrey L., Wright, Linnzi K.M., Connis, Nick, Lumley, Lucille A.

“…The development and deployment of next-generation therapeutics to protect military and civilian personnel against chemical warfare nerve agent threats require…”
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