Search Results - "Conney, Allan H."

Synthesis and evaluation of curcumin-related compounds for anticancer activity by Wei, Xingchuan, Du, Zhi-Yun, Zheng, Xi, Cui, Xiao-Xing, Conney, Allan H., Zhang, Kun

“…Sixty-one curcumin-related compounds were synthesized and evaluated for their anticancer activity toward cultured prostate cancer PC-3 cells, pancreas cancer…”
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Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2 by Xu, Changjiang, Huang, Mou-Tuan, Shen, Guoxiang, Yuan, Xiaoling, Lin, Wen, Khor, Tin Oo, Conney, Allan H, Kong, Ah-Ng Tony

“…Sulforaphane, a dietary isothiocyanate, possesses potent chemopreventive effects through the induction of cellular detoxifying/antioxidant enzymes via the…”
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Impact of Nrf2 on UVB-induced skin inflammation/photoprotection and photoprotective effect of sulforaphane by Saw, Constance L., Huang, Mou-Tuan, Liu, Yue, Khor, Tin Oo, Conney, Allan H., Kong, Ah-Ng

“…Ultraviolet (UV) of sunlight is a complete carcinogen that can burn skin, enhance inflammation, and drive skin carcinogenesis. Previously, we have shown that…”
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Effects of Curcumin Analogues for Inhibiting Human Prostate Cancer Cells and the Growth of Human PC-3 Prostate Xenografts in Immunodeficient Mice by Zhou, Dai-Ying, Ding, Ning, Doren, Jeremiah Van, Wei, Xing-Chuan, Du, Zhi-Yun, Conney, Allan H., Zhang, Kun, Zheng, Xi

“…Four curcumin analogues ((2E,6E)-2,6-bis(thiophen-3-methylene) cyclohexanone (AS), (2E,5E)-2,5-bis(thiophen-3-methylene) cyclopentanone (BS),…”
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ATR–Chk1 Pathway Inhibition Promotes Apoptosis after UV Treatment in Primary Human Keratinocytes: Potential Basis for the UV Protective Effects of Caffeine by Heffernan, Timothy P., Kawasumi, Masaoki, Blasina, Alessandra, Anderes, Kenna, Conney, Allan H., Nghiem, Paul

“…New approaches to prevent and reverse UV damage are needed to combat rising sunlight-induced skin cancer rates. Mouse studies have shown that oral or topical…”
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Synthesis and Evaluation of Curcumin-Related Compounds Containing Benzyl Piperidone for Their Effects on Human Cancer Cells by Zhou, Dai-Ying, Zhang, Kun, Conney, Allan H., Ding, Ning, Cui, Xiao-Xing, Wang, Hui, Verano, Michael, Zhao, Su-qing, Fan, Yan-Xiong, Zheng, Xi, Du, Zhi-Yun

“…Eleven curcumin-related compounds containing a benzyl piperidone moiety were synthesized and evaluated for their effects on cultured prostate cancer PC-3…”
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Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice by TIN OO KHOR, KEUM, Young-Sam, CONNEY, Allan H, KONG, Ah-Ng Tony, WEN LIN, KIM, Jung-Hwan, RONG HU, GUOXIANG SHEN, CHANGJIANG XU, GOPALAKRISHNAN, Avanthika, REDDY, Bandaru, XI ZHENG

“…Earlier studies using prostate cancer cells in culture showed that phenethyl isothiocyanate (PEITC) and curcumin have significant chemopreventive and possibly…”
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A triple combination of atorvastatin, celecoxib and tipifarnib strongly inhibits pancreatic cancer cells and xenograft pancreatic tumors by DING, NING, CUI, XIAO-XING, GAO, ZHI, HUANG, HUARONG, WEI, XINGCHUAN, DU, ZHIYUN, LIN, YONG, SHIH, WEICHUNG JOE, RABSON, ARNOLD B, CONNEY, ALLAN H, HU, CHUNHONG, ZHENG, XI

“…Because K-Ras mutation and cyclooxygenase-2 (COX-2) overexpression are hallmarks of majority of pancreatic cancer patients, an approach to inhibit the…”
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Synthesis and biological evaluation of unsymmetrical curcumin analogues as tyrosinase inhibitors by Jiang, Yongfu, Du, Zhiyun, Xue, Guihua, Chen, Qian, Lu, Yujing, Zheng, Xi, Conney, Allan H, Zhang, Kun

“…Synthesis and biological evaluation of unsymmetrical curcumin analogues (UCAs) have been achieved. Tyrosinase inhibitory activities were found for most of the…”
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Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase by Kawasumi, Masaoki, Lemos, Bianca, Bradner, James E, Thibodeau, Renee, Kim, Yong-son, Schmidt, Miranda, Higgins, Erin, Koo, Sang-wahn, Angle-Zahn, Aimee, Chen, Adam, Levine, Douglas, Nguyen, Lynh, Heffernan, Timothy P, Longo, Isabel, Mandinova, Anna, Lu, Yao-Ping, Conney, Allan H, Nghiem, Paul

“…Multiple human epidemiologic studies link caffeinated (but not decaffeinated) beverage intake with significant decreases in several types of cancer, including…”
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Topical Applications of Caffeine or (-)-Epigallocatechin Gallate (EGCG) Inhibit Carcinogenesis and Selectively Increase Apoptosis in UVB-Induced Skin Tumors in Mice by Lu, Yao-Ping, Lou, You-Rong, Xie, Jian-Guo, Peng, Qing-Yun, Liao, Jie, Yang, Chung S., Huang, Mou-Tuan, Conney, Allan H.

“…SKH-1 hairless mice were irradiated with ultraviolet B (UVB) twice weekly for 20 weeks. These tumor-free mice, which had a high risk of developing skin tumors…”
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Mechanisms of Caffeine-Induced Inhibition of UVB Carcinogenesis by Conney, Allan H, Lu, Yao-Ping, Lou, You-Rong, Kawasumi, Masaoki, Nghiem, Paul

“…Sunlight-induced non-melanoma skin cancer is the most prevalent cancer in the United States with more than two million cases per year. Several studies have…”
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Surgical removal of the parametrial fat pads stimulates apoptosis and inhibits UVB-induced carcinogenesis in mice fed a high-fat diet by Lu, Yao-Ping, Lou, You-Rong, Bernard, Jamie J., Peng, Qing-Yun, Li, Tao, Lin, Yong, Shih, Weichung Joe, Nghiem, Paul, Shapses, Sue, Wagner, George C., Conney, Allan H.

“…Removal of the parametrial fat pads (partial lipectomy) from female SKH-1 mice fed a high-fat diet inhibited UVB-induced carcinogenesis, but this was not…”
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Atorvastatin and celecoxib in combination inhibits the progression of androgen-dependent LNCaP xenograft prostate tumors to androgen independence by Zheng, Xi, Cui, Xiao-Xing, Gao, Zhi, Zhao, Yang, Lin, Yong, Shih, Weichung Joe, Huang, Mou-Tuan, Liu, Yue, Rabson, Arnold, Reddy, Bandaru, Yang, Chung S, Conney, Allan H

“…Epidemiology studies suggest that statins and nonsteroidal anti-inflammatory drugs reduce the risk of prostate cancer. In the present study, LNCaP cells were…”
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Induction of drug-metabolizing enzymes: A path to the discovery of multiple cytochromes P450 by CONNEY, Allan H

“…This article provides a personal account of the discovery of the induced synthesis of drug-metabolizing enzymes and of subsequent research that led to the…”
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Atorvastatin and Celecoxib Inhibit Prostate PC-3 Tumors in Immunodeficient Mice by XI ZHENG, CUI, Xiao-Xing, RABSON, Arnold B, REDDY, Bandaru S, CONNEY, Allan H, AVILA, Gina E, HUANG, Mou-Tuan, YUE LIU, PATEL, Jagruti, KONG, Ah Ng Tony, PAULINE, Raphael, JOE SHIH, Weichung, YONG LIN

“…Purpose: To investigate the effects and mechanisms of atorvastatin and celecoxib administered individually or in combination on human prostate cancer PC-3…”
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Inhibition of IL-6 expression in LNCaP prostate cancer cells by a combination of atorvastatin and celecoxib by WANG, HUAQIAN, CUI, XIAO-XING, GOODIN, SUSAN, DING, NING, VAN DOREN, JEREMIAH, DU, ZHIYUN, HUANG, MOU-TUAN, LIU, YUE, CHENG, XIAODONG, DIPAOLA, ROBERT S, CONNEY, ALLAN H, ZHENG, XI

“…In the present study, we investigated the effect of a combination of atorvastatin and celecoxib on the formation of interleukin (IL)-6, a cytokine that is…”
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STRONG INHIBITORY EFFECTS OF COMMON TEA CATECHINS AND BIOFLAVONOIDS ON THE O-METHYLATION OF CATECHOL ESTROGENS CATALYZED BY HUMAN LIVER CYTOSOLIC CATECHOL-O-METHYLTRANSFERASE by NAGAI, Mime, CONNEY, Allan H, BAO TING ZHU

“…In the present investigation, we studied the inhibitory effects of three tea catechins [catechin, epicatechin, and (-)-epigallocatechin-3- O -gallate] and two…”
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Inhibitory Effect of a γ-Tocopherol-Rich Mixture of Tocopherols on the Formation and Growth of LNCaP Prostate Tumors in Immunodeficient Mice by Zheng, Xi, Cui, Xiao-Xing, Khor, Tin Oo, Huang, Ying, Dipaola, Robert S, Goodin, Susan, Lee, Mao-Jung, Yang, Chung S, Kong, Ah-Ng, Conney, Allan H

“…In the present study, we determined the effects of a γ-tocopherol-rich mixture of tocopherols (γ-TmT) on the growth and apoptosis of cultured human prostate…”
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Stimulatory effect of topical application of caffeine on UVB-induced apoptosis in the epidermis of p53 and bax knockout mice by LU, Yao-Ping, LOU, You-Rong, PENG, Qing-Yun, XIE, Jian-Guo, CONNEY, Allan H

“…Shaved male or female p53(-/-) C57BL/6J mice and their wild-type littermates were irradiated once with UVB (60 mJ/cm(2)). The UVB-induced increase in apoptotic…”
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