Search Results - "Conner, Michael W"

Paul M. Newberne (1920–2015) by Conner, Michael W.

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Gut-Selective Design of Orally Administered Izencitinib (TD-1473) Limits Systemic Exposure and Effects of Janus Kinase Inhibition in Nonclinical Species by Hardwick, Rhiannon N, Brassil, Patrick, Badagnani, Ilaria, Perkins, Kimberly, Obedencio, Glenmar P, Kim, Andrea S, Conner, Michael W, Bourdet, David L, Harstad, Eric B

“…Abstract Izencitinib (TD-1473), an oral, gut-selective pan-Janus kinase (JAK) inhibitor under investigation for treatment of inflammatory bowel diseases, was…”
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Peroxisome Proliferator-Activated Receptors γ and α Mediate in Vivo Regulation of Uncoupling Protein (UCP-1, UCP-2, UCP-3) Gene Expression by Kelly, Linda J, Vicario, Pasquale P, Thompson, G. Marie, Candelore, Mari R, Doebber, Thomas W, Ventre, John, Wu, Margaret S, Meurer, Roger, Forrest, Michael J, Conner, Michael W, Cascieri, Margaret A, Moller, David E

“…A role for peroxisome proliferator-activated receptors, PPARγ and PPARα, as regulators of energy homeostasis and lipid metabolism, has been suggested…”
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Effect of IL‐2‐Bax, a novel interleukin‐2‐receptor‐targeted chimeric protein, on bleomycin lung injury1 by Segel, Michael J., Aqeilan, Rami, Zilka, Keren, Lorberboum‐Galski, Haya, Wallach‐Dayan, Shulamit B., Conner, Michael W., Christensen, Thomas G., Breuer, Raphael

“…Summary The role of lymphocytes in the pathogenesis of lung fibrosis is not clear, but the weight of the evidence supports a pro‐fibrotic effect for…”
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The Role of the Toxicologic Pathologist in the Biopharmaceutical Industry by van Tongeren, Susan, Fagerland, Jane A., Conner, Michael W., Diegel, Kelly, Donnelly, Kevin, Grubor, Branka, Lopez-Martinez, Alric, Bolliger, Anne Provencher, Sharma, Alok, Tannehill-Gregg, Sarah, Turner, Patricia V., Wancket, Lyn M.

“…Toxicologic pathologists contribute significantly to the development of new biopharmaceuticals, yet there is often a lack of awareness of this specialized…”
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Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice by Kohl, Nancy E, Omer, Charles A, Conner, Michael W, Anthony, Neville J, Davide, Joseph P, Desolms, S. Jane, Giuliani, Elizabeth A, Gomez, Robert P, Graham, Samuel L, Hamilton, Kelly, Handt, Laurence K, Hartman, George D, Koblan, Kenneth S, Kral, Astrid M, Miller, Patricia J, Mosser, Scott D, O'Neill, Timothy J, Rands, Elaine, Schaber, Michael D, Gibbs, Jackson B, Oliff, Allen

“…For Ras oncoproteins to transform mammalian cells, they must be post-translationally modified with a farnesyl group in a reaction catalysed by the enzyme…”
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A Farnesyltransferase Inhibitor Induces Tumor Regression in Transgenic Mice Harboring Multiple Oncogenic Mutations by Mediating Alterations in Both Cell Cycle Control and Apoptosis by Barrington, Rebecca E., Subler, Mark A., Rands, Elaine, Omer, Charles A., Miller, Patricia J., Hundley, Jeffrey E., Koester, Steven K., Troyer, Dean A., Bearss, David J., Conner, Michael W., Gibbs, Jackson B., Hamilton, Kelly, Koblan, Kenneth S., Mosser, Scott D., O'Neill, Timothy J., Schaber, Michael D., Senderak, Edith T., Windle, Jolene J., Oliff, Allen, Kohl, Nancy E.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl :protein transferase inhibitor by OMER, C. A, ZUNXUAN CHEN, DAVIDE, J. P, ELLIS, M. S, GIBBS, J. B, GREENBERG, I, HAMILTON, K, KOBLAN, K. S, KRAL, A. M, DONGMING LIU, LOBELL, R. B, MILLER, P. J, DIEHL, R. E, MOSSER, S. D, O'NEILL, T. J, RANDS, E, SCHABER, M. D, SENDERAK, E. T, OLIFF, A, KOHL, N. E, CONNER, M. W, CHEN, H. Y, TRUMBAUER, M. E, GOPAL-TRUTER, S, SEEBURGER, G, BHIMNATHWALA, H, ABRAMS, M. T

“…For Ras oncoproteins to transform mammalian cells, they must be posttranslationally modified with a farnesyl group in a reaction catalyzed by the enzyme…”
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Effect of IL-2-Bax, a novel interleukin-2-receptor-targeted chimeric protein, on bleomycin lung injury by Segel, Michael J., Aqeilan, Rami, Zilka, Keren, Lorberboum-Galski, Haya, Wallach-Dayan, Shulamit B., Conner, Michael W., Christensen, Thomas G., Breuer, Raphael

“…The role of lymphocytes in the pathogenesis of lung fibrosis is not clear, but the weight of the evidence supports a pro-fibrotic effect for lymphocytes. The…”
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Comparison of motility and membrane integrity to assess rat sperm viability by Vetter, Christine M., Miller, Judith E., Crawford, Lisa M., Armstrong, Michael J., Clair, James H., Conner, michael W., Wise, L.David, Skopek, Thomas R.

“…Rat sperm motility and membrane integrity were compared as endpoints for viability. Sperm motility was measured by computer-assisted semen analysis (CASA),…”
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African Art and the Internet by Conner, Michael W.

“…A survey has revealed that 83% of college freshmen in the US use the Internet for homework and research. It is argued that library research has declined in…”
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The influence of food additives and related materials on lower bowel structure and function by Newberne, P M, Conner, M W, Estes, P

“…Food additives, drugs, and other chemicals are known to influence the lower gastrointestinal tract under some defined conditions, resulting in morphological…”
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β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity by Zheng, Hui, Jiang, Minghao, Trumbauer, Myrna E., Sirinathsinghji, Dalip J.S., Hopkins, Ruth, Smith, David W., Heavens, Robert P., Dawson, Gerard R., Boyce, Susan, Conner, Michael W., Stevens, Karla A., Slunt, Hilda H., Sisodia, Sangram S., Chen, Howard Y., Van der Ploeg, Lex H.T.

“…In several pedigrees of early onset familial Alzheimer's disease (FAD), point mutations in the β-amyloid precursor protein (APP) gene are genetically linked to…”
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Protein Farnesyltransferase Inhibitors Block the Growth of ras-Dependent Tumors in Nude Mice by Kohl, Nancy E., Wilson, Francine R., Mosser, Scott D., Giuliani, Elizabeth, deSolms, S. Jane, Conner, Michael W., Anthony, Neville J., Holtz, Wilbur J., Gomez, Robert P., Lee, Ta-Jyh, Smith, Robert L., Graham, Samuel L., Hartman, George D., Gibbs, Jackson B., Oliff, Allen

“…The posttranslational addition of a farnesyl moiety to the Ras oncoprotein is essential for its transforming activity. Cell-active inhibitors of the enzyme…”
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Lung injury in guinea pigs caused by multiple exposures to ultrafine zinc oxide: changes in pulmonary lavage fluid by Conner, M W, Flood, W H, Rogers, A E, Amdur, M O

“…Metal oxide particles with diameters of less than 0.1 micron (ultrafine particles) are important products of fossil fuel combustion. Pulmonary lavage fluid was…”
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Coal combustion aerosols and sulfur dioxide: an interdisciplinary analysis by Amdur, Mary O, Sarofim, Adel F, Neville, Matthew, Quann, Richard J, McCarthy, John F, Elliott, John F, Lam, Hua Fuan, Rogers, Adrianne E, Conner, Michael W

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ORIGINAL ARTICLE: Effect of IL-2-Bax, a novel interleukin-2-receptor-targeted chimeric protein, on bleomycin lung injury by Segel, Michael J, Aqeilan, Rami, Zilka, Keren, Lorberboum-Galski, Haya, Wallach-Dayan, Shulamit B, Conner, Michael W, Christensen, Thomas G, Breuer, Raphael

“…The role of lymphocytes in the pathogenesis of lung fibrosis is not clear, but the weight of the evidence supports a pro-fibrotic effect for lymphocytes. The…”
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Effect of IL‐2‐Bax, a novel interleukin‐2‐receptor‐targeted chimeric protein, on bleomycin lung injury 1 by Segel, Michael J., Aqeilan, Rami, Zilka, Keren, Lorberboum‐Galski, Haya, Wallach‐Dayan, Shulamit B., Conner, Michael W., Christensen, Thomas G., Breuer, Raphael

“…The role of lymphocytes in the pathogenesis of lung fibrosis is not clear, but the weight of the evidence supports a pro‐fibrotic effect for lymphocytes. The…”
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2-Substituted Piperazines as Constrained Amino Acids. Application to the Synthesis of Potent, Non Carboxylic Acid Inhibitors of Farnesyltransferase by Williams, Theresa M, Ciccarone, Terrence M, MacTough, Suzanne C, Bock, Rhonda L, Conner, Michael W, Davide, Joseph P, Hamilton, Kelly, Koblan, Kenneth S, Kohl, Nancy E, Kral, Astrid M, Mosser, Scott D, Omer, Charles A, Pompliano, David L, Rands, Elaine, Schaber, Michael D, Shah, Daksha, Wilson, Francine R, Gibbs, Jackson B, Graham, Samuel L, Hartman, George D, Oliff, Allen I, Smith, Robert L

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Development of inhibitors of protein farnesylation as potential chemotherapeutic agents by Kohl, N E, Conner, M W, Gibbs, J B, Graham, S L, Hartman, G D, Oliff, A

“…Protein prenylation, adding either the 15-carbon isoprenoid farnesyl or the 20-carbon isoprenoid geranylgeranyl to cysteine residue(s) at or near the C-termini…”
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