A Double-Blind, Placebo-Controlled Trial of the Effect of Chronically Administered Oral Acyclovir on Sperm Production in Men With Frequently Recurrent Genital Herpes

Recurrent genital herpes simplex virus (HSV) infection is a common clinical problem in the United States. Therapy with oral acyclovir, a guanosine analogue that inhibits DNA polymerase, is effective in reducing the duration of first and recurrent episodes of genital herpes. Although oral acyclovir h...

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Bibliographic Details
Published in:	The Journal of infectious diseases Vol. 157; no. 3; pp. 588 - 592
Main Authors:	Douglas, John M., Davis, Gray, Remington, Michael L., Paulsen, C. Alvin, Perrin, Edward B., Goodman, Phyllis, Conner, James D., King, Dannie, Corey, Lawrence
Format:	Journal Article
Language:	English
Published:	Chicago, IL The University of Chicago Press 01-03-1988 University of Chicago Press
Subjects:	Acyclovir - administration & dosage Acyclovir - adverse effects Acyclovir - analysis Acyclovir - therapeutic use Administration, Oral Adult Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Clinical Trials as Topic Concise Clinical and Laboratory Communications Double-Blind Method Genital herpes Genitalia Health care administration Herpes Genitalis - drug therapy Herpes Genitalis - microbiology Herpes Genitalis - physiopathology herpes simplex virus Humans Infections Male Medical sciences Oligospermia Pharmacology. Drug treatments Placebos Recurrence Semen Semen - analysis Semen - microbiology Simplexvirus - isolation & purification Specimens Sperm Count - drug effects Sperm Motility - drug effects Spermatozoa Spermatozoa - drug effects Viruses Infection Chemotherapy Semen Viral disease Placebo Oral administration Double blind study Herpes Antiviral Controlled therapeutic trial Recurrent Male genital system
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Summary:	Recurrent genital herpes simplex virus (HSV) infection is a common clinical problem in the United States. Therapy with oral acyclovir, a guanosine analogue that inhibits DNA polymerase, is effective in reducing the duration of first and recurrent episodes of genital herpes. Although oral acyclovir has been used in daily suppressive therapy for up to three years without clinically important adverse effects, there remains concern about the potential for toxicity of a chronically administered, systemically active inhibitor of DNA synthesis. Because chronically administered oral acyclovir will probably be used by men with a future interest in reproduction, the authors conducted an evaluation of semen obtained from men with frequently recurrent genital herpes who were involved in a double-blind, placebo-controlled trial of daily administration of oral acyclovir to determine whether chronic suppressive therapy influences sperm production.
Bibliography:	ark:/67375/HXZ-V640039N-T Please address requests for reprints to Dr. John M. Douglas, Jr. at his present address: Denver Disease Control Service, 605 Bannock Street, Denver Colorado 80204. istex:E2DFF7BA432016B5E39D1BAD086C865E2A15ABA7 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0022-1899 1537-6613
DOI:	10.1093/infdis/157.3.588