Search Results - "Connelley, Timothy K."

Comparative transcriptional analysis identifies genes associated with the attenuation of Theileria parva infected cells after long-term in vitro culture by van der Heijden, Elisabeth M. D. L., Lefevre, Lucas, Gossner, Anton, Tzelos, Thomas, Connelley, Timothy K., Hassan, Musa A.

“…Autologous administration of attenuated Theileria parva -infected cells induces immunity to T. parva in cattle. The mechanism of attenuation, however, is…”
Get full text

Identification and Phenotype of MAIT Cells in Cattle and Their Response to Bacterial Infections by Edmans, Matthew D, Connelley, Timothy K, Jayaraman, Siddharth, Vrettou, Christina, Vordermeier, Martin, Mak, Jeffrey Y W, Liu, Ligong, Fairlie, David P, Maze, Emmanuel Atangana, Chrun, Tiphany, Klenerman, Paul, Eckle, Sidonia B G, Tchilian, Elma, Benedictus, Lindert

“…Mucosal-associated invariant T (MAIT) cells are a population of innate-like T cells that utilize a semi-invariant T cell receptor (TCR) α chain and are…”
Get full text

Anti-parasitic benzoxaboroles are ineffective against Theileria parva in vitro by Steketee, Pieter C., Paxton, Edith, Barrett, Michael P., Pearce, Michael C., Connelley, Timothy K., Morrison, Liam J.

“…East Coast Fever (ECF) is a disease affecting cattle in sub-Saharan Africa, caused by the tick-borne Apicomplexan pathogen Theileria parva. The disease is a…”
Get full text

Protein Levels of Pro-Inflammatory Cytokines and Chemokines as Biomarkers of Mycobacterium bovis Infection and BCG Vaccination in Cattle by Khalid, Hamza, van Hooij, Anouk, Connelley, Timothy K., Geluk, Annemieke, Hope, Jayne C.

“…Bovine tuberculosis (bTB), caused by Mycobacterium bovis, is a globally prevalent infectious disease with significant animal welfare and economic impact…”
Get full text

Development of lateral flow assays to detect host proteins in cattle for improved diagnosis of bovine tuberculosis by Khalid, Hamza, Pierneef, Louise, van Hooij, Anouk, Zhou, Zijie, de Jong, Danielle, Tjon Kon Fat, Elisa, Connelley, Timothy K., Hope, Jayne C., Corstjens, Paul L. A. M., Geluk, Annemieke

“…Bovine tuberculosis (bTB), caused by Mycobacterium bovis ( M. bovis ) infection in cattle, is an economically devastating chronic disease for livestock…”
Get full text

γδ TCRs Function as Innate-like Receptors in the Bovine γδ T Cell Response against Leptospira by Gillespie, Alexandria E, Loonie, Kathleen, Lefevre, Lucas, Hope, Jayne C, Baldwin, Cynthia L, Connelley, Timothy K

“…Leptospira serovar Hardjo are bacterial pathogens of cattle that also cause zoonotic disease in humans. Vaccine-mediated protection against Leptospira serovar…”
Get full text

MAIT cell-MR1 reactivity is highly conserved across multiple divergent species by Edmans, Matthew D., Connelley, Timothy K., Morgan, Sophie, Pediongco, Troi J., Jayaraman, Siddharth, Juno, Jennifer A., Meehan, Bronwyn S., Dewar, Phoebe M., Maze, Emmanuel A., Roos, Eduard O., Paudyal, Basudev, Mak, Jeffrey Y.W., Liu, Ligong, Fairlie, David P., Wang, Huimeng, Corbett, Alexandra J., McCluskey, James, Benedictus, Lindert, Tchilian, Elma, Klenerman, Paul, Eckle, Sidonia B.G.

“…Mucosal-associated invariant T (MAIT) cells are a subset of unconventional T cells that recognize small molecule metabolites presented by major…”
Get full text

Bovine T cell receptors and γδ WC1 co-receptor transcriptome analysis during the first month of life by Damani-Yokota, Payal, Gillespie, Alexandria, Pasman, Yfke, Merico, Daniel, Connelley, Timothy K., Kaushik, Azad, Baldwin, Cynthia L.

“…Here we evaluated neonatal transcription of α, β, γ and δ TCR and the γδ T cell co-receptor family WC1 in peripheral blood mononuclear cells. A previous report…”
Get full text

Genomic analysis offers insights into the evolution of the bovine TRA/TRD locus by Connelley, Timothy K, Degnan, Kathryn, Longhi, Cassandra W, Morrison, W Ivan

“…The TRA/TRD locus contains the genes for V(D)J somatic rearrangement of TRA and TRD chains expressed by αβ and γδ T cells respectively. Previous studies have…”
Get full text

NKp46+ CD3+ cells: a novel nonconventional T cell subset in cattle exhibiting both NK cell and T cell features by Connelley, Timothy K, Longhi, Cassandra, Burrells, Alison, Degnan, Kathryn, Hope, Jayne, Allan, Alasdair J, Hammond, John A, Storset, Anne K, Morrison, W Ivan

“…The NKp46 receptor demonstrates a high degree of lineage specificity, being expressed almost exclusively in NK cells. Previous studies have demonstrated NKp46…”
Get full text

Strain-dependent cellular immune responses in cattle following Escherichia coli O157:H7 colonization by Corbishley, Alexander, Ahmad, Nur Indah, Hughes, Kirsty, Hutchings, Michael R, McAteer, Sean P, Connelley, Timothy K, Brown, Helen, Gally, David L, McNeilly, Tom N

“…Enterohemorrhagic Escherichia coli (EHEC) O157:H7 causes hemorrhagic diarrhea and potentially fatal renal failure in humans. Ruminants are considered to be the…”
Get full text

Haematopoietic depletion in vaccine-induced neonatal pancytopenia depends on both the titre and specificity of alloantibody and levels of MHC I expression by Bell, Charlotte R, MacHugh, Niall D, Connelley, Timothy K, Degnan, Kathryn, Morrison, W. Ivan

“…Highlights • MHC I-specific alloantibodies play a dominant role in Bovine Neonatal Pancytopenia. • 50% of Pregsure-vaccinated cows produce MDBK-MHC I-specific…”
Get full text

CD8 T‐cell responses against the immunodominant Theileria parva peptide Tp249–59 are composed of two distinct populations specific for overlapping 11‐mer and 10‐mer epitopes by Connelley, Timothy K., Li, Xiaoying, MacHugh, Niall, Colau, Didier, Graham, Simon P., Bruggen, Pierre, Taracha, Evans L., Gill, Andy, Morrison, William Ivan

“…Summary Immunity against Theileria parva is associated with CD8 T‐cell responses that exhibit immunodominance, focusing the response against limited numbers of…”
Get full text

Identification of epitopes recognised by mucosal CD4(+) T-cell populations from cattle experimentally colonised with Escherichia coli O157:H7 by Corbishley, Alexander, Connelley, Timothy K, Wolfson, Eliza B, Ballingall, Keith, Beckett, Amy E, Gally, David L, McNeilly, Tom N

“…Vaccines targeting enterohaemorrhagic Escherichia coli (EHEC) O157:H7 shedding in cattle are only partially protective. The correlates of protection of these…”
Get full text

Escape from CD8+ T cell response by natural variants of an immunodominant epitope from Theileria parva is predominantly due to loss of TCR recognition by Connelley, Timothy K, MacHugh, Niall D, Pelle, Roger, Weir, William, Morrison, W Ivan

“…Polymorphism of immunodominant CD8(+) T cell epitopes can facilitate escape from immune recognition of pathogens, leading to strain-specific immunity. In this…”
Get full text

CD 8 T‐cell responses against the immunodominant Theileria parva peptide Tp2 49–59 are composed of two distinct populations specific for overlapping 11‐mer and 10‐mer epitopes by Connelley, Timothy K., Li, Xiaoying, MacHugh, Niall, Colau, Didier, Graham, Simon P., van der Bruggen, Pierre, Taracha, Evans L., Gill, Andy, Morrison, William Ivan

“…Summary Immunity against Theileria parva is associated with CD 8 T‐cell responses that exhibit immunodominance, focusing the response against limited numbers…”
Get full text

NKp46+CD3+ cells - a novel non-conventional T-cell subset in cattle exhibiting both NK cell and T-cell features by Connelley, Timothy K., Longhi, Cassandra, Burrells, Alison, Degnan, Kathryn, Hope, Jayne, Allan, Alasdair, Hammond, John A., Storset, Anne K., Morrison, W. Ivan

“…The NKp46 receptor demonstrates a high degree of lineage-specificity, being expressed almost exclusively in natural killer cells. Previous studies have…”
Get full text