Leucapheresis for management of retinopathy in chronic myeloid leukaemia

Leucapheresis for management of retinopathy in chronic myeloid leukaemia

Chronic myeloid leukaemia is a myeloproliferative neoplasm characterised by granulocytic hyperplasia in the bone marrow and the presence of a specific cytogenetic abnormality known as Philadelphia chromosome with fusion of breakpoint cluster region (BCR) and ableson (ABL) genes. Retinopathy is a rar...

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Bibliographic Details
Published in:BMJ case reports Vol. 2015; p. bcr2015212889
Main Authors: Mohamed, Muhajir, Oakley, Carmen, McEwen, Fiona, Connelley, Georgina
Format: Journal Article
Language:English
Published: England BMJ Publishing Group LTD 01-12-2015
BMJ Publishing Group
Series:Case Report
Subjects:
Abdomen
Australasia
Bone marrow
Chromosomes
Dasatinib - therapeutic use
Drugs
Endothelium
Growth factors
Humans
Leukapheresis
Leukemia
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - complications
Male
Middle Aged
Multiple myeloma
Philadelphia Chromosome
Protein Kinase Inhibitors - therapeutic use
Unusual Presentation of More Common Disease/Injury
Vision Disorders - etiology
Vision Disorders - therapy
Visual impairment
White
Online Access:Get full text
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Summary:Chronic myeloid leukaemia is a myeloproliferative neoplasm characterised by granulocytic hyperplasia in the bone marrow and the presence of a specific cytogenetic abnormality known as Philadelphia chromosome with fusion of breakpoint cluster region (BCR) and ableson (ABL) genes. Retinopathy is a rare sight-threatening complication of chronic myeloid leukaemia, which occurs due to leucostasis in retinal blood vessels. We report a case of a patient who presented with visual impairment due to leucostasis, who was successfully managed by leucapheresis along with BCR-ABL tyrosine kinase inhibitor.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr-2015-212889