Search Results - "Connell, James W"

Defects in ER-endosome contacts impact lysosome function in hereditary spastic paraplegia by Allison, Rachel, Edgar, James R, Pearson, Guy, Rizo, Tania, Newton, Timothy, Günther, Sven, Berner, Fiamma, Hague, Jennifer, Connell, James W, Winkler, Jürgen, Lippincott-Schwartz, Jennifer, Beetz, Christian, Winner, Beate, Reid, Evan

“…Contacts between endosomes and the endoplasmic reticulum (ER) promote endosomal tubule fission, but the mechanisms involved and consequences of tubule fission…”
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An ESCRT-spastin interaction promotes fission of recycling tubules from the endosome by Allison, Rachel, Lumb, Jennifer H, Fassier, Coralie, Connell, James W, Ten Martin, Daniel, Seaman, Matthew N J, Hazan, Jamilé, Reid, Evan

“…Mechanisms coordinating endosomal degradation and recycling are poorly understood, as are the cellular roles of microtubule (MT) severing. We show that cells…”
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Spastin Couples Microtubule Severing to Membrane Traffic in Completion of Cytokinesis and Secretion by Connell, James W, Lindon, Catherine, Luzio, J. Paul, Reid, Evan

“…Mutations in the gene encoding the microtubule (MT)-severing protein spastin are the most common cause of hereditary spastic paraplegia, a genetic condition in…”
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Quantitative Gait Analysis Using a Motorized Treadmill System Sensitively Detects Motor Abnormalities in Mice Expressing ATPase Defective Spastin by Connell, James W, Allison, Rachel, Reid, Evan

“…The hereditary spastic paraplegias (HSPs) are genetic conditions in which there is progressive axonal degeneration in the corticospinal tract. Autosomal…”
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Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5 by Edwards, Thomas L, Clowes, Virginia E, Tsang, Hilda T H, Connell, James W, Sanderson, Christopher M, Luzio, J Paul, Reid, Evan

“…The HSPs (hereditary spastic paraplegias) are genetic conditions in which there is distal degeneration of the longest axons of the corticospinal tract,…”
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A systematic analysis of human CHMP protein interactions: Additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex by Tsang, Hilda T.H., Connell, James W., Brown, Stephanie E., Thompson, Amanda, Reid, Evan, Sanderson, Christopher M.

“…In Saccharomyces cerevisiae 6 closely related proteins (Did2p, Vps2p, Vps24p, Vps32p, Vps60p, Vps20p) form part of the extended ESCRT III complex. This complex…”
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Spastin and atlastin, two proteins mutated in autosomal-dominant hereditary spastic paraplegia, are binding partners by Sanderson, Christopher M., Connell, James W., Edwards, Thomas L., Bright, Nicholas A., Duley, Simon, Thompson, Amanda, Luzio, J. Paul, Reid, Evan

“…The pure hereditary spastic paraplegias (HSPs) are a group of conditions in which there is a progressive length-dependent degeneration of the distal ends of…”
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ESCRT-III-associated proteins and spastin inhibit protrudin-dependent polarised membrane traffic by Connell, James W., Allison, Rachel J., Rodger, Catherine E., Pearson, Guy, Zlamalova, Eliska, Reid, Evan

“…Mutations in the gene encoding the microtubule severing ATPase spastin are the most frequent cause of hereditary spastic paraplegia, a genetic condition…”
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The AAA ATPase spastin links microtubule severing to membrane modelling by Lumb, Jennifer H., Connell, James W., Allison, Rachel, Reid, Evan

“…In 1999, mutations in the gene encoding the microtubule severing AAA ATPase spastin were identified as a major cause of a genetic neurodegenerative condition…”
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The hereditary spastic paraplegia proteins NIPA1, spastin and spartin are inhibitors of mammalian BMP signalling by Tsang, Hilda T.H., Edwards, Thomas L., Wang, Xinnan, Connell, James W., Davies, Rachel J., Durrington, Hannah J., O'Kane, Cahir J., Luzio, J. Paul, Reid, Evan

“…The hereditary spastic paraplegias (HSPs) are genetic conditions characterized by distal axonopathy of the longest corticospinal tract axons, and so their…”
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Effects of FTDP-17 mutations on the in vitro phosphorylation of tau by glycogen synthase kinase 3β identified by mass spectrometry demonstrate certain mutations exert long-range conformational changes by Connell, James W, Gibb, Graham M, Betts, Joanna C, Blackstock, Walter P, Gallo, Jean-Marc, Lovestone, Simon, Hutton, Michael, Anderton, Brian H

“…In vitro phosphorylation of recombinant wild-type 2N4R tau and FTDP-17 exonic mutant forms P301L, V337M and R406W by glycogen synthase kinase 3β (GSK3β) was…”
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