Search Results - "Connell, Gregory J"

Neither miR-7-5p nor miR-141-3p is a major mediator of iron-responsive transferrin receptor-1 mRNA degradation by Corral, Victor M, Schultz, Eric R, Connell, Gregory J

“…The transferrin receptor (TfR1) is the principal means of iron importation for most mammalian cells, and regulation of mRNA stability is a major mechanism…”
Get full text

Roquin is a major mediator of iron-regulated changes to transferrin receptor-1 mRNA stability by Corral, Victor M., Schultz, Eric R., Eisenstein, Richard S., Connell, Gregory J.

“…Transferrin receptor-1 (TfR1) has essential iron transport and proposed signal transduction functions. Proper TfR1 regulation is a requirement for…”
Get full text

A temporal difference in the stabilization of two mRNAs with a 3' iron-responsive element during iron deficiency by Connell, Gregory J, Abasiri, Ikedinachukwu Michael, Chaney, Elizabeth H

“…The interactions of iron regulatory proteins (IRPs) with mRNAs containing an iron-responsive element (IRE) maintain cellular iron homeostasis and coordinate it…”
Get full text

Transferrin receptor mRNA interactions contributing to iron homeostasis by Rupani, Dhwani N, Connell, Gregory J

“…The transferrin receptor is the primary means of iron importation for most mammalian cells and understanding its regulatory mechanisms is relevant to…”
Get full text

Evaluation of the iron regulatory protein-1 interactome by Connell, Gregory J., Danial, Jando S., Haastruthers, Christian X.

“…The interactions of iron regulatory proteins (IRPs) with mRNAs containing an iron-responsive element (IRE) is a major means through which intracellular iron…”
Get full text

Identification of specific inhibitors for a trypanosomatid RNA editing reaction by Liang, Shuang, Connell, Gregory J

“…Several mitochondrial mRNAs of the trypanosomatid protozoa are edited through the post-transcriptional insertion and deletion of uridylates. The reaction has…”
Get full text

An electrochemiluminescent aptamer switch for a high-throughput assay of an RNA editing reaction by Liang, Shuang, Connell, Gregory J

“…An RNA editing reaction that is both essential and specific to the trypanosomatid parasites is an attractive target for new drug development. Although…”
Get full text

Molecular cloning, primary structure, and orientation of the vertebrate photoreceptor cell protein peripherin in the rod outer segment disk membrane by Connell, Gregory J, Molday, Robert S

“…Peripherin, a 39-kDa membrane protein, has been previously localized to the rim region of the vertebrate rod photoreceptor disk membrane by use of monoclonal…”
Get full text

Cis-acting Elements Stimulating Kinetoplastid Guide RNA-directed Editing by Oppegard, Lisa M., Hillestad, Matthew, McCarthy, Ryan T., Pai, Raj D., Connell, Gregory J.

“…The coding sequence of several mitochondrial mRNAs of the kinetoplastid protozoa is created through the insertion and deletion of specific uridylates. The…”
Get full text

Three small ribooligonucleotides with specific arginine sites by Connell, Gregory J, Illangesekare, Mali, Yarus, Michael

“…Arginine-binding RNA motifs are important to protein-RNA interaction and perhaps also for Archean biochemistry. Selection-amplification was used to isolate…”
Get full text

RNAs with Dual Specificity and Dual RNAs with Similar Specificity by Connell, Gregory J., Yarus, Michael

“…The biological role of RNA is delimited by its possible reactions, which can be explored by selection. A comparison of selected RNAs that bind one ligand with…”
Get full text

The Hairpin Loop but Not the Bulged C of the Iron Responsive Element Is Essential for High Affinity Binding to Iron Regulatory Protein-1 by Meehan, Heather A., Connell, Gregory J.

“…Vertebrates control intracellular iron concentration principally through the interaction of iron regulatory proteins with mRNAs that contain an iron responsive…”
Get full text

Sequence and structural requirements for optimal guide RNA-directed insertional editing within Leishmania tarentolae by Pai, Raj D, Oppegard, Lisa M, Connell, Gregory J

“…The coding sequence of several mitochondrial mRNAs of the trypanosomatid family of protozoa is created by the guide RNA-directed insertion and deletion of…”
Get full text

Direct visualisation of RNA editing within a Leishmania tarentolae mitochondrial extract by OPPEGARD, Lisa M, CONNELL, Gregory J

“…The coding sequence within several mitochondrial mRNAs of the trypanosomatid protozoa is created through editing by the precise insertion and deletion of U…”
Get full text

Activation of Guide RNA-directed Editing of a Cytochromeb mRNA by Oppegard, Lisa M., Kabb, Aaron L., Connell, Gregory J.

“…The coding sequence of several mitochondrial mRNAs of the kinetoplastid protozoa is created only after the addition or deletion of specific uridines. Although…”
Get full text

pH dependent conformational changes within the iron responsive element by Meehan, Heather A, Connell, Gregory J

“…The expression of several mRNAs related to iron importation, storage and utilization within mammalian cells are regulated through interactions of iron…”
Get full text

A mRNA determinant of gRNA-directed kinetoplastid editing by Kabb, A L, Oppegard, L M, McKenzie, B A, Connell, G J

“…Several mitochondrial mRNAs of the kinetoplastid protozoa do not encode a functional open reading frame until they have been edited through the addition or…”
Get full text

A Cis-acting A-U Sequence Element Induces Kinetoplastid U-insertions by Brown, L M, Burbach, B J, McKenzie, B A, Connell, G J

“…A 34-nucleotide A-U sequence located immediately upstream of the editing sites of the Leishmania tarentolae cytochrome b mRNA induces a mitochondrial extract…”
Get full text

Guide RNA-independent and Guide RNA-dependent Uridine Insertion into Cytochrome b mRNA in a Mitochondrial Lysate from Leishmania tarentolae by Connell, Gregory J., Byrne, Elaine M., Simpson, Larry

“…A primer extension assay was used for the detection of uridine insertions occurring in vitro in synthetic pre-edited cytochrome b mRNA during incubation with a…”
Get full text

Guide RNA‐directed uridine insertion RNA editing in vitro by Byrne, E. M., Connell, G. J., Simpson, L.

“…Guide RNAs (gRNAs) have been proposed to mediate uridine (U) addition/deletion editing of mitochondrial mRNAs in kinetoplastid protozoa. The Us are proposed to…”
Get full text