Search Results - "Connaughton, Haley"

Oxidative stress and human spermatozoa: diagnostic and functional significance of aldehydes generated as a result of lipid peroxidation by Moazamian, Ryan, Polhemus, Ashley, Connaughton, Haley, Fraser, Barbara, Whiting, Sara, Gharagozloo, Parviz, Aitken, Robert John

“…Oxidative stress is known to compromise human sperm function and to activate the intrinsic apoptotic cascade in these cells. One of the key features of…”
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Sperm Motility Is Lost In Vitro as a Consequence of Mitochondrial Free Radical Production and the Generation of Electrophilic Aldehydes but Can Be Significantly Rescued by the Presence of Nucleophilic Thiols by AITKEN, R. John, GIBB, Zamira, MITCHELL, Lisa A, LAMBOURNE, Sarah R, CONNAUGHTON, Haley S, DE LULIIS, Geoffry N

“…The prolonged incubation of human spermatozoa in vitro was found to induce a loss of motility associated with the activation of mitochondrial reactive oxygen…”
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The presence of a truncated base excision repair pathway in human spermatozoa that is mediated by OGG1 by Smith, Tegan B, Dun, Matthew D, Smith, Nathan D, Curry, Ben J, Connaughton, Haley S, Aitken, Robert J

“…DNA repair has long been considered impossible in human spermatozoa due to the high level of DNA compaction observed in these cells. However, detailed…”
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Boronate probes for the detection of hydrogen peroxide release from human spermatozoa by Purdey, Malcolm S., Connaughton, Haley S., Whiting, Sara, Schartner, Erik P., Monro, Tanya M., Thompson, Jeremy G., Aitken, R. John, Abell, Andrew D.

“…Human spermatozoa are compromised by production of reactive oxygen species (ROS), and detection of ROS in spermatozoa is important for the diagnosis of male…”
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Impacts of obesity, maternal obesity and nicotinamide mononucleotide supplementation on sperm quality in mice by Youngson, Neil A, Uddin, G Mezbah, Das, Abhirup, Martinez, Carl, Connaughton, Haley S, Whiting, Sara, Yu, Josephine, Sinclair, David A, Aitken, R John, Morris, Margaret J

“…Male fertility and sperm quality are negatively impacted by obesity. Furthermore, recent evidence has shown that male offspring from obese rat mothers also…”
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289 : Mitochondrial Activator BGP-15 Protects Sperm from DNA Damage During Sperm Recovery for Assisted Reproductive Technology by Gonzalez, Macarena, Connaughton, Haley, Barry, Michael, Robker, Rebecca, Rose, Ryan

“…Background and Aims: The recovery of sperm by assisted reproductive technology (ART) results in significant DNA damage. Elevated levels of DNA damage in sperm…”
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Restoring Sperm Quality Post-Cryopreservation Using Mitochondrial-Targeted Compounds by Gonzalez, Macarena, Prashar, Tanisha, Connaughton, Haley, Barry, Michael, Robker, Rebecca, Rose, Ryan

“…While critical for male fertility preservation, cryopreservation damage reduces sperm quality and fertilization potential. This study investigated whether the…”
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Drinking water quality impacts oocyte viability and embryo development by Winstanley, Yasmyn E, Gonzalez, Macarena B, Andreas, Eryk, Connaughton, Haley, Bergen, Jean, Ween, Miranda, Russell, Darryl L, Shearer, Cameron J, Robertson, Sarah A, Robker, Rebecca L

“…Normal reproductive function and fertility is considered a "sixth vital sign" because disruptions to this sensitive physiological system can forewarn other…”
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Sperm Motility Is Lost In Vitro as a Consequence of Mitochondrial Free Radical Production and the Generation of Electrophilic Aldehydes but Can Be Significantly Rescued by the Presence of Nucleophilic Thiols1 by Aitken, R. John, Gibb, Zamira, Mitchell, Lisa A, Lambourne, Sarah R, Connaughton, Haley S, De Iuliis, Geoffry N

“…The prolonged incubation of human spermatozoa in vitro was found to induce a loss of motility associated with the activation of mitochondrial reactive oxygen…”
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A novel pathway for the induction of DNA damage in human spermatozoa involving extracellular cell-free DNA by Aitken, Robert John, Whiting, Sara, Connaughton, Haley, Curry, Ben, Reinheimer, Torsten, van Duin, Marcel

“…DNA damage is a common feature of human spermatozoa associated with an impaired capacity to fertilize the oocyte and an increased mutational load in the…”
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REPRODUCTIVE AGEING: BGP-15 mitigates adverse impacts of aging on sperm quality, fertility, and offspring health in male mice by Gonzalez, Macarena B, Campugan, Carl A, Connaughton, Haley S, Andreas, Eryk, Winstanley, Yasmyn E, Williams, Elisha J, Dorian, Camilla L, Robertson, Sarah A, Shoubridge, Cheryl, Robker, Rebecca L

“…Aging in men is associated with diminished sperm quality and a higher incidence of altered fetal development and miscarriage in resultant pregnancies. This…”
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