Search Results - "Conn, Crystal S."

Differential Requirements for eIF4E Dose in Normal Development and Cancer by Truitt, Morgan L., Conn, Crystal S., Shi, Zhen, Pang, Xiaming, Tokuyasu, Taku, Coady, Alison M., Seo, Youngho, Barna, Maria, Ruggero, Davide

“…eIF4E, the major cap-binding protein, has long been considered limiting for translating the mammalian genome. However, the eIF4E dose requirement at an…”
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Development of a stress response therapy targeting aggressive prostate cancer by Nguyen, Hao G, Conn, Crystal S, Kye, Yae, Xue, Lingru, Forester, Craig M, Cowan, Janet E, Hsieh, Andrew C, Cunningham, John T, Truillet, Charles, Tameire, Feven, Evans, Michael J, Evans, Christopher P, Yang, Joy C, Hann, Byron, Koumenis, Constantinos, Walter, Peter, Carroll, Peter R, Ruggero, Davide

“…Oncogenic lesions up-regulate bioenergetically demanding cellular processes, such as protein synthesis, to drive cancer cell growth and continued…”
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The integrated stress response in cancer progression: a force for plasticity and resistance by Lines, Caleb L., McGrath, Morgan J., Dorwart, Tanis, Conn, Crystal S.

“…During their quest for growth, adaptation, and survival, cancer cells create a favorable environment through the manipulation of normal cellular mechanisms…”
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Translational control of the cytosolic stress response by mitochondrial ribosomal protein L18 by Zhang, Xingqian, Gao, Xiangwei, Coots, Ryan Alex, Conn, Crystal S, Liu, Botao, Qian, Shu-Bing

“…A stress-induced cytosolic isoform of the mitochondrial ribosomal protein MRPL18 facilitates the specific translation of heat-shock proteins during the general…”
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mTOR signaling in protein homeostasis: Less is more? by Conn, Crystal S., Qian, Shu-Bing

“…A proper balance between synthesis, maturation and degradation of cellular proteins is crucial for cells to maintain physiological functions. The costly…”
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Targeting stress induction of GRP78 by cardiac glycoside oleandrin dually suppresses cancer and COVID-19 by Ha, Dat P, Shin, Woo-Jin, Liu, Ze, Doche, Michael E, Lau, Roy, Leli, Nektaria Maria, Conn, Crystal S, Russo, Mariangela, Lorenzato, Annalisa, Koumenis, Constantinos, Yu, Min, Mumenthaler, Shannon M, Lee, Amy S

“…Despite recent therapeutic advances, combating cancer resistance remains a formidable challenge. The 78-kilodalton glucose-regulated protein (GRP78), a key…”
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Reduced eIF4E function impairs B-cell leukemia without altering normal B-lymphocyte function by Chiu, Honyin, Buono, Roberta, Jackson, Leandra V., Herzog, Lee-or, Mallya, Sharmila, Conn, Crystal S., Ruggero, Davide, Fruman, David A.

“…The cap-binding protein eukaryotic initiation factor 4E (eIF4E) promotes translation of mRNAs associated with proliferation and survival and is an attractive…”
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ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression by Tameire, Feven, Verginadis, Ioannis I., Leli, Nektaria Maria, Polte, Christine, Conn, Crystal S., Ojha, Rani, Salas Salinas, Carlo, Chinga, Frank, Monroy, Alexandra. M., Fu, Weixuan, Wang, Paul, Kossenkov, Andrew, Ye, Jiangbin, Amaravadi, Ravi K., Ignatova, Zoya, Fuchs, Serge Y., Diehl, J. Alan, Ruggero, Davide, Koumenis, Constantinos

“…The c- Myc oncogene drives malignant progression and induces robust anabolic and proliferative programmes leading to intrinsic stress. The mechanisms enabling…”
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PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy by Zhang, Duo, Li, Albert M., Hu, Guanghui, Huang, Menggui, Yang, Fan, Zhang, Lin, Wellen, Kathryn E., Xu, Xiaowei, Conn, Crystal S., Zou, Wei, Kahn, Mark, Rhoades, Seth D., Weljie, Aalim M., Fuchs, Serge Y., Amankulor, Nduka, Yoshor, Daniel, Ye, Jiangbin, Koumenis, Constantinos, Gong, Yanqing, Fan, Yi

“…The efficacy of immunotherapy is limited by the paucity of T cells delivered and infiltrated into the tumors through aberrant tumor vasculature. Here, we…”
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Nutrient signaling in protein homeostasis: an increase in quantity at the expense of quality by Conn, Crystal S, Qian, Shu-Bing

“…The discovery that rapamycin extends the life span of diverse organisms has triggered many studies aimed at identifying the underlying molecular mechanisms…”
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Ribosomal Proteins Regulate MHC Class I Peptide Generation for Immunosurveillance by Wei, Jiajie, Kishton, Rigel J., Angel, Matthew, Conn, Crystal S., Dalla-Venezia, Nicole, Marcel, Virginie, Vincent, Anne, Catez, Frédéric, Ferré, Sabrina, Ayadi, Lilia, Marchand, Virginie, Dersh, Devin, Gibbs, James S., Ivanov, Ivaylo P., Fridlyand, Nathan, Couté, Yohann, Diaz, Jean-Jacques, Qian, Shu-Bing, Staudt, Louis M., Restifo, Nicholas P., Yewdell, Jonathan W.

“…The MHC class I antigen presentation system enables T cell immunosurveillance of cancers and viruses. A substantial fraction of the immunopeptidome derives…”
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Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase by Gwinn, Dana M., Lee, Alex G., Briones-Martin-del-Campo, Marcela, Conn, Crystal S., Simpson, David R., Scott, Anna I., Le, Anthony, Cowan, Tina M., Ruggero, Davide, Sweet-Cordero, E. Alejandro

“…KRAS is a regulator of the nutrient stress response in non-small-cell lung cancer (NSCLC). Induction of the ATF4 pathway during nutrient depletion requires AKT…”
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PI3K-mTORC1 Attenuates Stress Response by Inhibiting Cap-independent Hsp70 Translation by Sun, Jun, Conn, Crystal S., Han, Yan, Yeung, Vincent, Qian, Shu-Bing

“…Protein synthesis is a key regulated cellular process that links nutrient availability and organismal growth. It has long been known that some cellular…”
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The major cap-binding protein eIF4E regulates lipid homeostasis and diet-induced obesity by Conn, Crystal S., Yang, Haojun, Tom, Harrison J., Ikeda, Kenji, Oses-Prieto, Juan A., Vu, Hieu, Oguri, Yasuo, Nair, Supna, Gill, Ryan M., Kajimura, Shingo, DeBerardinis, Ralph J., Burlingame, Alma L., Ruggero, Davide

“…Obesity is a global epidemic leading to increased mortality and susceptibility to comorbidities, with few viable therapeutic interventions. A hallmark of…”
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Author Correction: ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression by Tameire, Feven, Verginadis, Ioannis I., Leli, Nektaria Maria, Polte, Christine, Conn, Crystal S., Ojha, Rani, Salinas, Carlo Salas, Chinga, Frank, Monroy, Alexandra. M., Fu, Weixuan, Wang, Paul, Kossenkov, Andrew, Ye, Jiangbin, Amaravadi, Ravi K., Ignatova, Zoya, Fuchs, Serge Y., Diehl, J. Alan, Ruggero, Davide, Koumenis, Constantinos

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Noninvasive Measurement of mTORC1 Signaling with 89Zr-Transferrin by Truillet, Charles, Cunningham, John T., Parker, Matthew F.L., Huynh, Loc T., Conn, Crystal S., Ruggero, Davide, Lewis, Jason S., Evans, Michael J.

“…Abstract Purpose: mTOR regulates many normal physiological processes and when hyperactive can drive numerous cancers and human diseases. However, it is very…”
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Viewing folding of nascent polypeptide chains from ribosomes by Liu, Botao, Conn, Crystal S, Qian, Shu-Bing

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couples MYC-dependent translational activity to bioenergetic demands during tumour progression by Tameire, Feven, Verginadis, Ioannis I, Leli, Nektaria Maria, Polte, Christine, Conn, Crystal S, Ojha, Rani, Salas Salinas, Carlo

“…The c-Myc oncogene drives malignant progression and induces robust anabolic and proliferative programmes leading to intrinsic stress. The mechanisms enabling…”
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Noninvasive Measurement of mTORC1 Signaling with 89 Zr-Transferrin by Truillet, Charles, Cunningham, John T, Parker, Matthew F L, Huynh, Loc T, Conn, Crystal S, Ruggero, Davide, Lewis, Jason S, Evans, Michael J

“…mTOR regulates many normal physiological processes and when hyperactive can drive numerous cancers and human diseases. However, it is very challenging to…”
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Abstract A25: Sensing stress in cancer: a novel therapy targeting protein synthesis through the unfolded protein response in prostate cancer development by Conn, Crystal S., Nguyen, Hao G., Kye, Yae, Cunningham, John T., Truillet, Charles, Evans, Michael, Huynh, Tony L., Walters, Peter, Ruggero, Davide

“…Abstract Distinct oncogenic lesions within components of the Myc or PI3K pathways hijack the translation machinery, to establish an aberrant “cancer proteome”,…”
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