Search Results - "Conn, Charlotte"

Encapsulation in egg white protein nanoparticles protects anti-oxidant activity of curcumin by Chang, Cuihua, Meikle, Thomas G., Su, Yujie, Wang, Xuting, Dekiwadia, Chaitali, Drummond, Calum J., Conn, Charlotte E., Yang, Yanjun

“…•The particle size of EWP nanoparticle increased with addition of curcumin solution.•Ethanol would induce more α-helix transferred to β-sheet during heating…”
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Fusion dynamics of cubosome nanocarriers with model cell membranes by Dyett, Brendan P., Yu, Haitao, Strachan, Jamie, Drummond, Calum J., Conn, Charlotte E.

“…Drug delivery with nanocarriers relies on the interaction of individual nanocarriers with the cell surface. For lipid-based NCs, this interaction uniquely…”
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Toxicity and cellular uptake of lipid nanoparticles of different structure and composition by Strachan, Jamie B., Dyett, Brendan P., Nasa, Zeyad, Valery, Celine, Conn, Charlotte E.

“…[Display omitted] Cubosomes form part of the next generation of lipid nanoparticle drug delivery vehicles, enabling higher drug encapsulation efficiency,…”
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Preparation, Characterization, and Antimicrobial Activity of Cubosome Encapsulated Metal Nanocrystals by Meikle, Thomas G, Dyett, Brendan P, Strachan, Jamie B, White, Jacinta, Drummond, Calum J, Conn, Charlotte E

“…Herein, we demonstrate a method for the functionalization of cubic phase lipid nanoparticles (cubosomes) with a series of magnetite (Fe3O4), copper oxide…”
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Investigating casein gel structure during gastric digestion using ultra-small and small-angle neutron scattering by Bayrak, Meltem, Mata, Jitendra, Raynes, Jared K., Greaves, Mark, White, Jacinta, Conn, Charlotte E., Floury, Juliane, Logan, Amy

“…[Display omitted] •The first study to monitor gastric devolution of casein gels using USANS and SANS.•Gels prepared in D2O exhibit earlier onset of gelation,…”
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Formation of particulate lipid lyotropic liquid crystalline nanocarriers using a microfluidic platform by Yu, Haitao, Dyett, Brendan P., Zhai, Jiali, Strachan, Jamie B., Drummond, Calum J., Conn, Charlotte E.

“…[Display omitted] Non-lamellar lyotropic liquid crystal nanoparticles (LLCNPs) are gaining significant interest in the fields of drug delivery and…”
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Cuboplex-Mediated Nonviral Delivery of Functional siRNA to Chinese Hamster Ovary (CHO) Cells by Sarkar, Sampa, Tran, Nhiem, Soni, Sarvesh Kumar, Nasa, Zeyad, Drummond, Calum J, Conn, Charlotte E

“…Lipid nanoparticles of internal cubic symmetry, termed cuboplexes, are potential nonviral delivery vehicles for gene therapy due to their “topologically…”
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Uptake Dynamics of Cubosome Nanocarriers at Bacterial Surfaces and the Routes for Cargo Internalization by Dyett, Brendan P, Yu, Haitao, Sarkar, Sampa, Strachan, Jamie B, Drummond, Calum J, Conn, Charlotte E

“…Antibiotic-resistant bacteria pose a significant threat to humanity. Gram-negative strains have demonstrated resistance to last resort antibiotics, partially…”
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Cell interactions with lipid nanoparticles possessing different internal nanostructures: Liposomes, bicontinuous cubosomes, hexosomes, and discontinuous micellar cubosomes by Yap, Sue Lyn, Yu, Haitao, Li, Shiyao, Drummond, Calum J., Conn, Charlotte E., Tran, Nhiem

“…[Display omitted] Lyotropic liquid crystalline nanoparticles (LLCNPs) with complex internal nanostructures hold promise for drug delivery. Cubosomes, in…”
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Incorporation of antimicrobial peptides in nanostructured lipid membrane mimetic bilayer cubosomes by Meikle, Thomas G., Zabara, Alexandru, Waddington, Lynne J., Separovic, Frances, Drummond, Calum J., Conn, Charlotte E.

“…[Display omitted] •Three antimicrobial peptides were encapsulated in various cubosome formulations.•Cubosomes were characterized using SAXS, cryo-TEM, circular…”
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Overcoming Therapeutic Challenges of Antibiotic Delivery with Cubosome Lipid Nanocarriers by Dyett, Brendan P., Sarkar, Sampa, Yu, Haitao, Strachan, Jamie, Drummond, Calum J., Conn, Charlotte E.

“…Low discovery rates for new antibiotics, commercial disincentives to invest, and inappropriate use of existing drugs have created a perfect storm of…”
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Protective effect of surfactant modified phytosterol oleogels on loaded curcumin by Li, Junhua, Zhai, Jiali, Chang, Cuihua, Yang, Yanjun, Drummond, Calum J., Conn, Charlotte E.

“…BACKGROUND Oleogels represent one of the most important carriers for the delivery of lipophilic nutraceuticals. Phytosterols (PS), plant‐derived natural sterol…”
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Analysis of the structure, loading and activity of six antimicrobial peptides encapsulated in cubic phase lipid nanoparticles by Meikle, Thomas G., Dharmadana, Durga, Hoffmann, Søren V., Jones, Nykola C., Drummond, Calum J., Conn, Charlotte E.

“…[Display omitted] The growing global threat of antimicrobial resistance, combined with the slowed development of novel antibiotics, has resulted in a critical…”
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Prospective Subunit Nanovaccine against Mycobacterium tuberculosis InfectionCubosome Lipid Nanocarriers of Cord Factor, Trehalose 6,6′ Dimycolate by Sarkar, Sampa, Mishra, Abhishek, Periasamy, Selvakannan, Dyett, Brendan, Dogra, Prashant, Ball, Andrew S., Yeo, Leslie Y., White, Jacinta F., Wang, Zhihui, Cristini, Vittorio, Jagannath, Chinnaswamy, Khan, Arshad, Soni, Sarvesh K., Drummond, Calum J., Conn, Charlotte E.

“…An improved vaccine is urgently needed to replace the now more than 100-year-old Bacillus Calmette–Guérin (BCG) vaccine against tuberculosis (TB) disease,…”
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Cellular uptake and in vitro antibacterial activity of lipid-based nanoantibiotics are influenced by protein corona by Subramaniam, Santhni, Joyce, Paul, Conn, Charlotte E, Prestidge, Clive A

“…Bacteria have evolved survival mechanisms that enable them to live within host cells, triggering persistent intracellular infections that present significant…”
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Real-time monitoring of casein gel microstructure during simulated gastric digestion monitored by small-angle neutron scattering by Bayrak, Meltem, Whitten, Andrew E., Mata, Jitendra P., Conn, Charlotte E., Floury, Juliane, Logan, Amy

“…The evolving structure of protein-based foods during the digestion process is critical to the release of nutrients. However, traditional in vitro monitoring of…”
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Novel bioactive cationic cubosomes enhance the cytotoxic effect of paclitaxel against a paclitaxel resistant prostate cancer cell-line by Pushpa Ragini, S., White, Jacinta, Kirby, Nigel, Banerjee, Rajkumar, Reddy Bathula, Surendar, Drummond, Calum J., Conn, Charlotte E.

“…[Display omitted] Hypothesis The study aimed to use molecular hybridization of a cationic lipid with a known pharmacophore to produce a bifunctional lipid…”
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Cubosome lipid nanocarriers for delivery of ultra-short antimicrobial peptides by Lakic, Biserka, Beh, Chia, Sarkar, Sampa, Yap, Sue-Lyn, Cardoso, Priscila, Valery, Celine, Hung, Andrew, Jones, Nykola C., Hoffmann, Søren Vrønning, Blanch, Ewan W., Dyett, Brendan, Conn, Charlotte E.

“…[Display omitted] Although antimicrobial peptides (AMPs) are a promising class of new antibiotics, their inherent susceptibility to degradation requires…”
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A systematic study of the effect of lipid architecture on cytotoxicity and cellular uptake of cationic cubosomes by Pushpa Ragini, S., Dyett, Brendan P., Sarkar, Sampa, Zhai, Jiali, White, Jacinta F., Banerjee, Rajkumar, Drummond, Calum J., Conn, Charlotte E.

“…[Display omitted] Lipid nanoparticles containing a cationic lipid are increasingly used in drug and gene delivery as they can display improved cellular uptake,…”
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Behavior of Citrate-Capped Ultrasmall Gold Nanoparticles on a Supported Lipid Bilayer Interface at Atomic Resolution by Kariuki, Rashad, Penman, Rowan, Bryant, Saffron J., Orrell-Trigg, Rebecca, Meftahi, Nastaran, Crawford, Russell J., McConville, Chris F., Bryant, Gary, Voïtchovsky, Kislon, Conn, Charlotte E., Christofferson, Andrew J., Elbourne, Aaron

“…Nanomaterials have the potential to transform biological and biomedical research, with applications ranging from drug delivery and diagnostics to targeted…”
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