Search Results - "Conlon, Donna M"

Sortilin restricts secretion of apolipoprotein B-100 by hepatocytes under stressed but not basal conditions by Conlon, Donna M, Schneider, Carolin V, Ko, Yi-An, Rodrigues, Amrith, Guo, Kathy, Hand, Nicholas J, Rader, Daniel J

“…Genetic variants at the SORT1 locus in humans, which cause increased SORT1 expression in the liver, are significantly associated with reduced plasma levels of…”
Get full text

Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice by Ai, Ding, Baez, Juan M, Jiang, Hongfeng, Conlon, Donna M, Hernandez-Ono, Antonio, Frank-Kamenetsky, Maria, Milstein, Stuart, Fitzgerald, Kevin, Murphy, Andrew J, Woo, Connie W, Strong, Alanna, Ginsberg, Henry N, Tabas, Ira, Rader, Daniel J, Tall, Alan R

“…Recent GWAS have identified SNPs at a human chromosom1 locus associated with coronary artery disease risk and LDL cholesterol levels. The SNPs are also…”
Get full text

Different fatty acids inhibit apoB100 secretion by different pathways: unique roles for ER stress, ceramide, and autophagy by Caviglia, Jorge Matias, Gayet, Constance, Ota, Tsuguhito, Hernandez-Ono, Antonio, Conlon, Donna M., Jiang, Hongfeng, Fisher, Edward A., Ginsberg, Henry N.

“…Although short-term incubation of hepatocytes with oleic acid (OA) stimulates secretion of apolipoprotein B100 (apoB100), exposure to higher doses of OA for…”
Get full text

Lack of MTTP Activity in Pluripotent Stem Cell-Derived Hepatocytes and Cardiomyocytes Abolishes apoB Secretion and Increases Cell Stress by Liu, Ying, Conlon, Donna M., Bi, Xin, Slovik, Katherine J., Shi, Jianting, Edelstein, Hailey I., Millar, John S., Javaheri, Ali, Cuchel, Marina, Pashos, Evanthia E., Iqbal, Jahangir, Hussain, M. Mahmood, Hegele, Robert A., Yang, Wenli, Duncan, Stephen A., Rader, Daniel J., Morrisey, Edward E.

“…Abetalipoproteinemia (ABL) is an inherited disorder of lipoprotein metabolism resulting from mutations in microsomal triglyceride transfer protein (MTTP). In…”
Get full text

A novel approach to measuring macrophage-specific reverse cholesterol transport in vivo in humans by Cuchel, Marina, Raper, Anna C., Conlon, Donna M., Pryma, Daniel A., Freifelder, Richard H., Poria, Rahul, Cromley, Debra, Li, Xiaoyu, Dunbar, Richard L., French, Benjamin, Qu, Liming, Farver, William, Su, Ching-Chiang, Lund-Katz, Sissel, Baer, Amanda, Ruotolo, Giacomo, Akerblad, Peter, Ryan, Carol S., Xiao, Lan, Kirchgessner, Todd G., Millar, John S., Billheimer, Jeffrey T., Rader, Daniel J.

“…Reverse cholesterol transport (RCT) is thought to be an atheroprotective function of HDL, and macrophage-specific RCT in mice is inversely associated with…”
Get full text

Role of sortilin in lipid metabolism by Conlon, Donna M

“…Sortilin, encoded SORT1 gene at chromosome 1p13.3, is a multiligand receptor that traffics protein from the Golgi to the endosomes, secretory vesicles, and the…”
Get full text

Sex-Specific Differences in Lipoprotein Production and Clearance by Conlon, Donna M., Welty, Francine K., Reyes-Soffer, Gissette, Amengual, Jaume

“…Therapeutic approaches to reduce atherogenic lipid and lipoprotein levels remain the most effective and assessable strategies to prevent and treat…”
Get full text

Functional Characterization of Organoids Derived From Irreversibly Damaged Liver of Patients With NASH by McCarron, Sarah, Bathon, Brooke, Conlon, Donna M., Abbey, Deepti, Rader, Daniel J., Gawronski, Katerina, Brown, Christopher D., Olthoff, Kim M., Shaked, Abraham, Raabe, Tobias D.

“…Background and Aims NASH will soon become the leading cause of liver transplantation in the United States and is also associated with increased COVID‐19…”
Get full text

TRIB1 regulates LDL metabolism through CEBPα-mediated effects on the LDL receptor in hepatocytes by Quiroz-Figueroa, Katherine, Vitali, Cecilia, Conlon, Donna M, Millar, John S, Tobias, John W, Bauer, Robert C, Hand, Nicholas J, Rader, Daniel J

“…Genetic variants near the TRIB1 gene are highly significantly associated with plasma lipid traits and coronary artery disease. While TRIB1 is likely causal of…”
Get full text

Inhibition of apolipoprotein B synthesis stimulates endoplasmic reticulum autophagy that prevents steatosis by Conlon, Donna M, Thomas, Tiffany, Fedotova, Tatyana, Hernandez-Ono, Antonio, Di Paolo, Gilbert, Chan, Robin B, Ruggles, Kelly, Gibeley, Sarah, Liu, Jing, Ginsberg, Henry N

“…Inhibition of VLDL secretion reduces plasma levels of atherogenic apolipoprotein B (apoB) lipoproteins but can also cause hepatic steatosis. Approaches…”
Get full text

A coding variant in the microsomal triglyceride transfer protein reduces both hepatic steatosis and plasma lipids by Schneider, Carolin V., Hehl, Leonida, Creasy, Kate T., Vitali, Cecilia, Vell, Mara S., Vujkovic, Marijana, Park, Joseph, Scorletti, Eleonora, Seeling, Katharina S., Rendel, Miriam D., Conlon, Donna M., Huang, Helen, Zandvakili, Inuk, Valmiki, Swati, Schneider, Kai Markus, Hussain, M. Mahmood, Rader, Daniel J.

“…Summary Background Genetic inactivation and pharmacologic inhibition of the microsomal triglyceride transfer protein (MTP; gene name MTTP) inhibits hepatic…”
Get full text

Genotype-First Approach Identifies an Association between rs28374544/FOG2S657G and Liver Disease through Alterations in mTORC1 Signaling by Conlon, Donna M, Kanakala, Siri, Cherlin, Tess, Yi-An, Ko, Vitali, Cecilia, Sharavana Gurunathan, Venkatesh, Rasika, Woerner, Jakob, Guare, Lindsay A, Penn Medicine Biobank, Verma, Anurag, Verma, Shefali S, Guerraty, Marie A

“…Metabolic dysfunction-associated Fatty Liver Disease (MAFLD) has emerged as one of the leading cardiometabolic diseases. Friend of GATA2 (FOG2) is a…”
Get full text

A genome-first approach to mortality and metabolic phenotypes in MTARC1 p.Ala165Thr (rs2642438) heterozygotes and homozygotes by Schneider, Carolin V, Schneider, Kai Markus, Conlon, Donna M, Park, Joseph, Vujkovic, Marijana, Zandvakili, Inuk, Ko, Yi-An, Trautwein, Christian, Center, Regerneron, Carr, Rotonya M, Strnad, Pavel, Thaiss, Christoph A, Rader, Daniel J

“…A coding variant in (rs2642438; p.Ala165Thr) was recently associated with protection from cirrhosis in European individuals. However, its impact on overall and…”
Get more information

Neuronal deficiency of ARV1 causes an autosomal recessive epileptic encephalopathy by Palmer, Elizabeth E, Jarrett, Kelsey E, Sachdev, Rani K, Al Zahrani, Fatema, Hashem, Mais Omar, Ibrahim, Niema, Sampaio, Hugo, Kandula, Tejaswi, Macintosh, Rebecca, Gupta, Rajat, Conlon, Donna M, Billheimer, Jeffrey T, Rader, Daniel J, Funato, Kouichi, Walkey, Christopher J, Lee, Chang Seok, Loo, Christine, Brammah, Susan, Elakis, George, Zhu, Ying, Buckley, Michael, Kirk, Edwin P, Bye, Ann, Alkuraya, Fowzan S, Roscioli, Tony, Lagor, William R

“…We report an individual who presented with severe neurodevelopmental delay and an intractable infantile-onset seizure disorder. Exome sequencing identified a…”
Get full text

Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-IgTM) molecule that specifically and potently neutralizes both IL-1α and IL-1β by Lacy, Susan E, Wu, Chengbin, Ambrosi, Dominic J, Hsieh, Chung-Ming, Bose, Sahana, Miller, Renee, Conlon, Donna M, Tarcsa, Edit, Chari, Ravi, Ghayur, Tariq, Kamath, Rajesh V

“…Interleukin-1 (IL-1) cytokines such as IL-1α, IL-1β, and IL-1Ra contribute to immune regulation and inflammatory processes by exerting a wide range of cellular…”
Get full text

Translocation Efficiency of Apolipoprotein B Is Determined by the Presence of β-Sheet Domains, Not Pause Transfer Sequences by Yamaguchi, Junji, Conlon, Donna M., Liang, John J., Fisher, Edward A., Ginsberg, Henry N.

“…Cotranslational translocation of apoB100 across the endoplasmic reticulum (ER) membrane is inefficient, resulting in exposure of nascent apoB on the cytosolic…”
Get full text

TRIB1 regulates LDL metabolism through CEBP[alpha]-mediated effects on the LDL receptor in hepatocytes by Quiroz-Figueroa, Katherine, Vitali, Cecilia, Conlon, Donna M, Millar, John S, Tobias, John W, Bauer, Robert C, Hand, Nicholas J, Rader, Daniel J

“…Genetic variants near the TRIB1 gene are highly significantly associated with plasma lipid traits and coronary artery disease. While TRIB1 is likely causal of…”
Get full text

Expression of cell growth and bone specific genes at single cell resolution during development of bone tissue-like organization in primary osteoblast cultures by Pockwinse, S M, Wilming, L G, Conlon, D M, Stein, G S, Lian, J B

“…Primary cultures of calvarial derived normal diploid osteoblasts undergo a developmental expression of genes reflecting growth, extracellular matrix…”
Get more information

Abstract 022: Hepatic Sortilin Regulates Apolipoprotein B Secretion only Under Conditions of Secretory StressDependent of the Presence of Secretory Stress by Conlon, Donna M, Rodrigues, Amrith, Guo, Kathy, Hand, Nicholas, Rader, Daniel

“…Abstract only SORT1 is strongly associated with plasma lipid traits and coronary artery disease. The protein it encodes, sortilin is a multi-ligand receptor…”
Get full text

Abstract 087: Hepatic Sortilin Regulates Apolipoprotein B Secretion only Under Conditions of Secretory StressDependent of the Presence of Secretory Stress by Conlon, Donna M, Rodrigues, Amrith, Guo, Kathy, Hand, Nicholas, Rader, Daniel

“…Abstract only SORT1 is strongly associated with plasma lipid traits and coronary artery disease. The protein it encodes, sortilin is a multi-ligand receptor…”
Get full text