Search Results - "Conley, Sabena M."

Nod-like Receptor Protein 3 (NLRP3) Inflammasome Activation and Podocyte Injury via Thioredoxin-Interacting Protein (TXNIP) during Hyperhomocysteinemia by Abais, Justine M., Xia, Min, Li, Guangbi, Chen, Yang, Conley, Sabena M., Gehr, Todd W.B., Boini, Krishna M., Li, Pin-Lan

“…NADPH oxidase-derived reactive oxygen species (ROS) have been reported to activate NLRP3 inflammasomes resulting in podocyte and glomerular injury during…”
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Inflammasome Activation in Chronic Glomerular Diseases by Conley, Sabena M, Abais, Justine M, Boini, Krishna M, Li, Pin-Lan

“…The intracellular multiprotein complex termed the inflammasome functions as a platform of pro-inflammatory cytokine production such as IL-1β and IL-18. Under…”
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NLRP3 inflammasome as a novel target for docosahexaenoic acid metabolites to abrogate glomerular injury[S] by Li, Guangbi, Chen, Zhida, Bhat, Owais M., Zhang, Qinghua, Abais-Battad, Justine M., Conley, Sabena M., Ritter, Joseph K., Li, Pin-Lan

“…The nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome has been implicated in podocyte injury and…”
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Impaired immunomodulatory capacity in adipose tissue‐derived mesenchymal stem/stromal cells isolated from obese patients by Zhu, Xiang‐Yang, Klomjit, Nattawat, Conley, Sabena M., Ostlie, Megan M., Jordan, Kyra L., Lerman, Amir, Lerman, Lilach O.

“…Immune‐modulatory properties of adipose tissue‐derived mesenchymal stem/stromal cells (MSCs) might be susceptible to metabolic disturbances. We hypothesized…”
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Rac1 GTPase Inhibition Blocked Podocyte Injury and Glomerular Sclerosis during Hyperhomocysteinemia via Suppression of Nucleotide-Binding Oligomerization Domain-Like Receptor Containing Pyrin Domain 3 Inflammasome Activation by Zhang, Qinghua, Conley, Sabena M., Li, Guangbi, Yuan, Xinxu, Li, Pin-Lan

“…Elevated homocysteine (Hcy) levels have been shown to activate nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3)…”
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Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells by Conley, Sabena M, Hickson, LaTonya J, Kellogg, Todd A, McKenzie, Travis, Heimbach, Julie K, Taner, Timucin, Tang, Hui, Jordan, Kyra L, Saadiq, Ishran M, Woollard, John R, Isik, Busra, Afarideh, Mohsen, Tchkonia, Tamar, Kirkland, James L, Lerman, Lilach O

“…Chronic inflammatory conditions like obesity may adversely impact the biological functions underlying the regenerative potential of mesenchymal stromal/stem…”
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Metabolic Syndrome Induces Release of Smaller Extracellular Vesicles from Porcine Mesenchymal Stem Cells by Conley, Sabena M., Shook, John E., Zhu, Xiang-Yang, Eirin, Alfonso, Jordan, Kyra L., Woollard, John R., Isik, Busra, Hickson, LaTonya J., Puranik, Amrutesh S., Lerman, Lilach O.

“…Mesenchymal stromal/stem cells (MSCs) belong to the endogenous cellular reparative system, and can be used exogenously in cell-based therapy. MSCs release…”
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Global epigenetic alterations of mesenchymal stem cells in obesity: the role of vitamin C reprogramming by Afarideh, Mohsen, Thaler, Roman, Khani, Farzaneh, Tang, Hui, Jordan, Kyra L., Conley, Sabena M., Saadiq, Ishran M., Obeidat, Yasin, Pawar, Aditya S., Eirin, Alfonso, Zhu, Xiang-Yang, Lerman, Amir, van Wijnen, Andre J., Lerman, Lilach O.

“…Obesity promotes dysfunction and impairs the reparative capacity of mesenchymal stem/stromal cells (MSCs), and alters their transcription, protein content, and…”
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A systematic review and meta‐analysis of cell‐based interventions in experimental diabetic kidney disease by Hickson, LaTonya J., Abedalqader, Tala, Ben‐Bernard, Gift, Mondy, Jayla M., Bian, Xiaohui, Conley, Sabena M., Zhu, Xiangyang, Herrmann, Sandra M., Kukla, Aleksandra, Lorenz, Elizabeth C., Kim, Seo Rin, Thorsteinsdottir, Bjorg, Lerman, Lilach O., Murad, M. Hassan

“…Regenerative, cell‐based therapy is a promising treatment option for diabetic kidney disease (DKD), which has no cure. To prepare for clinical translation,…”
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Hypoxic preconditioning induces epigenetic changes and modifies swine mesenchymal stem cell angiogenesis and senescence in experimental atherosclerotic renal artery stenosis by Isik, Busra, Thaler, Roman, Goksu, Busra B, Conley, Sabena M, Al-Khafaji, Hayder, Mohan, Arjunmohan, Afarideh, Mohsen, Abumoawad, Abdelrhman M, Zhu, Xiang Y, Krier, James D, Saadiq, Ishran M, Tang, Hui, Eirin, Alfonso, Hickson, LaTonya J, van Wijnen, Andre J, Textor, Stephen C, Lerman, Lilach O, Herrmann, Sandra M

“…Atherosclerotic renal artery stenosis (ARAS) is a risk factor for ischemic and hypertensive kidney disease (HKD) for which autologous mesenchymal stem cell…”
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Diabetic kidney disease induces transcriptome alterations associated with angiogenesis activity in human mesenchymal stromal cells by Bian, Xiaohui, Conley, Sabena M, Eirin, Alfonso, Zimmerman Zuckerman, Eric A, Smith, Anastasia L, Gowan, Cody C, Snow, Zachary K, Jarmi, Tambi, Farres, Houssam, Erben, Young M, Hakaim, Albert G, Dietz, Matthew A, Zubair, Abba C, Wyles, Saranya P, Wolfram, Joy V, Lerman, Lilach O, Hickson, LaTonya J

“…Therapeutic interventions that optimize angiogenic activities may reduce rates of end-stage kidney disease, critical limb ischemia, and lower extremity…”
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Inhibition of Hyperhomocysteinemia-Induced Inflammasome Activation and Glomerular Sclerosis by NLRP3 Gene Deletion by Xia, Min, Conley, Sabena M., Li, Guangbi, Li, Pin-Lan, Boini, Krishna M.

“…Background/Aims: Hyperhomocysteinemia (hHcys) has been reported to initiate Nod-like receptor protein 3 (NLRP3) inflammasome formation and activation in…”
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Comparable in vitro Function of Human Liver-Derived and Adipose Tissue-Derived Mesenchymal Stromal Cells: Implications for Cell-Based Therapy by Yigitbilek, Furkan, Conley, Sabena M, Tang, Hui, Saadiq, Ishran M, Jordan, Kyra L, Lerman, Lilach O, Taner, Timucin

“…Mesenchymal stem/stromal cells (MSCs) have been investigated extensively for their immunotherapeutic and regenerative properties, which may differ by cell…”
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Meprin Metalloprotease Deficiency Associated with Higher Mortality Rates and More Severe Diabetic Kidney Injury in Mice with STZ-Induced Type 1 Diabetes by Bylander, John E., Ahmed, Faihaa, Conley, Sabena M., Mwiza, Jean-Marie, Ongeri, Elimelda Moige

“…Meprins are membrane-bound and secreted metalloproteinases consisting of α and/or β subunits that are highly expressed in kidney epithelial cells and are…”
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Erratum to “Meprin Metalloprotease Deficiency Associated with Higher Mortality Rates and More Severe Diabetic Kidney Injury in Mice with STZ-Induced Type 1 Diabetes” by Mwiza, Jean-Marie, Conley, Sabena Michelle, Ahmed, Faihaa, Bylander, John E., Ongeri, Elimelda Moige

“…In the article titled “Meprin Metalloprotease Deficiency Associated with Higher Mortality Rates and More Severe Diabetic Kidney Injury in Mice with STZ-Induced…”
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Renovascular disease induces mitochondrial damage in swine scattered tubular cells by Nargesi, Arash Aghajani, Zhu, Xiang-Yang, Conley, Sabena M, Woollard, John R, Saadiq, Ishran M, Lerman, Lilach O, Eirin, Alfonso

“…Scattered tubular-like cells (STCs) contribute to repair neighboring injured renal tubular cells. Mitochondria mediate STC biology and function but might be…”
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Effects of obesity on reparative function of human adipose tissue-derived mesenchymal stem cells on ischemic murine kidneys by Klomjit, Nattawat, Conley, Sabena M., Zhu, Xiang Yang, Sadiq, Ishran M., Libai, Yaara, Krier, James D., Ferguson, Christopher M., Jordan, Kyra L., Tang, Hui, Lerman, Amir, Lerman, Lilach O.

“…Introduction Obesity is a health burden that impairs cellular processes. Mesenchymal stem/stromal cells (MSCs) are endowed with reparative properties and can…”
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Diabetic kidney disease alters the transcriptome and function of human adipose-derived mesenchymal stromal cells but maintains immunomodulatory and paracrine activities important for renal repair by Hickson, LaTonya J, Eirin, Alfonso, Conley, Sabena M, Taner, Timucin, Bian, Xiaohui, MBBCh, Ahmed Saad, Herrmann, Sandra M, Mehta, Ramila A, McKenzie, Travis J, Kellogg, Todd A, Kirkland, James L, Tchkonia, Tamar, Saadiq, Ishran M, Tang, Hui, Jordan, Kyra L, Zhu, Xiangyang, MBBCh, Mathew D Griffin, Rule, Andrew D, van Wijnen, Andre J, Textor, Stephen C, Lerman, Lilach O

“…Mesenchymal stem/stromal cells (MSC) facilitate repair in experimental diabetic kidney disease (DKD). However, the hyperglycemic and uremic milieu may diminish…”
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Metabolic syndrome alters expression of insulin signaling-related genes in swine mesenchymal stem cells by Conley, Sabena M., Zhu, Xiang-Yang, Eirin, Alfonso, Tang, Hui, Lerman, Amir, van Wijnen, Andre J., Lerman, Lilach O.

“…Metabolic syndrome (MetS) is associated with insulin resistance (IR) and impaired glucose metabolism in muscle, fat, and other cells, and may induce…”
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Microvascular remodeling and altered angiogenic signaling in human kidneys distal to occlusive atherosclerotic renal artery stenosis by Klomjit, Nattawat, Zhu, Xiang-Yang, Eirin, Alfonso, Pawar, Aditya S, Conley, Sabena M, Puranik, Amrutesh S, Ferguson, Christopher M, Kim, Seo Rin, Tang, Hui, Jordan, Kyra L, Saadiq, Ishran M, Lerman, Amir, Grande, Joseph P, Textor, Stephen C, Lerman, Lilach O

“…Renal artery stenosis (RAS) is an important cause of chronic kidney disease and secondary hypertension. In animal models, renal ischemia leads to…”
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