Search Results - "Conley, Emily Drabant"
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Interactions Between Anandamide and Corticotropin-Releasing Factor Signaling Modulate Human Amygdala Function and Risk for Anxiety Disorders: An Imaging Genetics Strategy for Modeling Molecular Interactions
Published in Biological psychiatry (1969) (01-09-2016)“…Preclinical models reveal that stress-induced amygdala activity and impairment in fear extinction reflect reductions in anandamide driven by…”
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Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways
Published in American journal of human genetics (01-08-2019)“…Susceptibility to schizophrenia is inversely correlated with general cognitive ability at both the phenotypic and the genetic level. Paradoxically, a modest…”
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Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modelling study
Published in Lancet neurology (01-10-2015)“…Summary Background Accurate diagnosis and early detection of complex diseases, such as Parkinson's disease, has the potential to be of great benefit for…”
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Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets
Published in Cell reports (Cambridge) (28-11-2017)“…Here, we present a large (n = 107,207) genome-wide association study (GWAS) of general cognitive ability (“g”), further enhanced by combining results with a…”
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Identifying nootropic drug targets via large-scale cognitive GWAS and transcriptomics
Published in Neuropsychopharmacology (New York, N.Y.) (01-09-2021)“…Broad-based cognitive deficits are an enduring and disabling symptom for many patients with severe mental illness, and these impairments are inadequately…”
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Interactions Between Anandamide and Corticotropin-Releasing Hormone Signaling Modulate Human Amygdala Function and Risk for Anxiety Disorders: An Imaging Genetics Strategy for Modeling Molecular Interactions
Published in Biological psychiatry (1969) (05-01-2016)“…Abstract Background Preclinical models reveal that stress-induced amygdala activity and impairment in fear extinction reflect reductions in anandamide driven…”
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PER1 rs3027172 Genotype Interacts with Early Life Stress to Predict Problematic Alcohol Use, but Not Reward-Related Ventral Striatum Activity
Published in Frontiers in psychology (31-03-2016)“…Increasing evidence suggests that the circadian and stress regulatory systems contribute to alcohol use disorder (AUD) risk, which may partially arise through…”
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Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
Published in Nature genetics (01-07-2018)“…Intelligence is highly heritable 1 and a major determinant of human health and well-being 2 . Recent genome-wide meta-analyses have identified 24 genomic loci…”
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Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
Published in Nature genetics (01-09-2014)“…Andrew Singleton and colleagues report a large-scale meta-analysis of genome-wide association data in Parkinson's disease using over 13,000 cases and 95,000…”
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Nonsteroidal Anti‐inflammatory Use and LRRK2 Parkinson's Disease Penetrance
Published in Movement disorders (01-10-2020)“…Background The penetrance of leucine rich repeat kinase 2 (LRRK2) mutations is incomplete and may be influenced by environmental and/or other genetic factors…”
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Hypothalamic-Pituitary-Adrenal Axis Genetic Variation and Early Stress Moderates Amygdala Function
Published in Psychoneuroendocrinology (01-06-2017)“…Highlights • HPA axis genetic profile and early life stress interact to predict amygdala function. • HPA axis genetic profile is associated with anxiety…”
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Effects of Schizophrenia Polygenic Risk Scores on Brain Activity and Performance During Working Memory Subprocesses in Healthy Young Adults
Published in Schizophrenia bulletin (06-06-2018)“…Abstract Recent work has begun to shed light on the neural correlates and possible mechanisms of polygenic risk for schizophrenia. Here, we map a schizophrenia…”
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Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders
Published in Neuron (Cambridge, Mass.) (03-06-2015)“…Depression risk is exacerbated by genetic factors and stress exposure; however, the biological mechanisms through which these factors interact to confer…”
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A Common Polymorphism in SCN2A Predicts General Cognitive Ability through Effects on PFC Physiology
Published in Journal of cognitive neuroscience (01-09-2015)“…Here we provide novel convergent evidence across three independent cohorts of healthy adults (n = 531), demonstrating that a common polymorphism in the gene…”
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FRAS1-related extracellular matrix 3 (FREM3) single-nucleotide polymorphism effects on gene expression, amygdala reactivity and perceptual processing speed: An accelerated aging pathway of depression risk
Published in Frontiers in psychology (16-09-2015)“…The A allele of the FRAS1-related extracellular matrix protein 3 (FREM3) rs7676614 single nucleotide polymorphism (SNP) was linked to major depressive disorder…”
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Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
Published in Nature communications (01-05-2019)“…Christina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article…”
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Reward-related ventral striatum activity links polygenic risk for attention-deficit/hyperactivity disorder to problematic alcohol use in young adulthood
Published in Biological psychiatry : cognitive neuroscience and neuroimaging (01-03-2017)“…Abstract Background Problematic alcohol use in adolescence and adulthood is a common and often debilitating correlate of childhood…”
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Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018)
Published in Twin research and human genetics (01-10-2018)“…Hill (Twin Research and Human Genetics, Vol. 21, 2018, 84–88) presented a critique of our recently published paper in Cell Reports entitled ‘Large-Scale…”
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Heart Rate Variability in LRRK2 Parkinson’s Disease (S37.004)
Published in Neurology (08-04-2014)“…Abstract only…”
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