Search Results - "Conlen, Patricia"

Discovery of Potent and Selective Inhibitors of Wild-Type and Gatekeeper Mutant Fibroblast Growth Factor Receptor (FGFR) 2/3 by Shvartsbart, Artem, Roach, Jeremy J., Witten, Michael R., Koblish, Holly, Harris, Jennifer J., Covington, Maryanne, Hess, Rodrigo, Lin, Luping, Frascella, Michelle, Truong, Lisa, Leffet, Lynn, Conlen, Patricia, Beshad, Elham, Klabe, Ron, Katiyar, Kamna, Kaldon, Laura, Young-Sciame, Ruth, He, Xin, Petusky, Susan, Chen, Kwang-Jong, Horsey, April, Lei, Hsiang-Ting, Epling, Leslie B., Deller, Marc C., Vechorkin, Oleg, Yao, Wenqing

“…Upregulation of the fibroblast growth factor receptor (FGFR) signaling pathway has been implicated in multiple cancer types, including cholangiocarcinoma and…”
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Abstract LB157: Discovery and characterization of INCB106385: a novel A2A/A2B adenosine receptor antagonist, as a cancer immunotherapy by Wang, Hui, Alexandra, Alexandra, Hansbury, Michael, Mason, Jennifer, Harris, Jennifer, Stevens, Christina, Maddage, Christopher, Ren, Xiaodi, Gao, Mingming, Kurzeja-Lipinski, Kerri, Yang, Gengjie, Conlen, Patricia, Stump, Kristine, Feldman, Patricia, Thekkat, Pramod, Lin, Luping, Covington, Maryanne, Yeleswaram, Swamy, Qi, Chao, Wang, Xiaozhao, Yao, Wenqing, Kim, Sunkyu, Wee, Susan, Chen, Yingnan, Koblish, Holly

“…In the tumor microenvironment, ATP released by dying cells is converted to adenosine, a well-established potent suppressor of immune cell activity. The immune…”
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Abstract 4513: The role of HPK1 in the regulation of T cell function and anti-tumor immune activity by Chen, Yaoyu, Rios-Doria, Jonathan, Pusey, Michelle, Lasky, Kerri, Ye, Min, Thekkat, Pramod, Gallagher, Karen, Stump, Kristine, Conlen, Patricia, Gardiner, Christine, Wang, Hui, Sokolsky, Alexander, Rupar, Mark, Lin, Luping, Behshad, Elham, Covington, Maryanne, Koblish, Holly, Vechorkin, Oleg, Yao, Wenqing, Kim, Sunkyu, Chen, Yingnan

“…Antigen recognition and T-cell receptor (TCR) activation are fundamental processes that drive anti-tumor T cell responses. HPK1 has been identified as a…”
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Discovery of Pyrazolopyridine Derivatives as HPK1 Inhibitors by Ye, Qinda, Liu, Kai, Ye, Hai-Fen, Pan, Jun, Sokolsky, Alexander, Wang, Anlai, Zhang, Ke, Hummel, Joshua R., Kong, Ling, Behshad, Elham, He, Xin, Conlen, Patricia, Stump, Kristine, Ye, Min, Diamond, Sharon, Covington, Maryanne, Yeleswaram, Swamy, Atasoylu, Onur, Vechorkin, Oleg, Yao, Wenqing

“…In spite of the great success of immune checkpoint inhibitors in immune-oncology therapy, an urgent need still exists to identify alternative approaches to…”
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Potent and Selective Biaryl Amide Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1) by Sokolsky, Alexander, Vechorkin, Oleg, Hummel, Joshua R., Styduhar, Evan D., Wang, Anlai, Nguyen, Minh H., Ye, Hai Fen, Liu, Kai, Zhang, Ke, Pan, Jun, Ye, Qinda, Atasoylu, Onur, Behshad, Elham, He, Xin, Conlen, Patricia, Stump, Kristine, Ye, Min, Diamond, Sharon, Covington, Maryanne, Yeleswaram, Swamy, Yao, Wenqing

“…Herein we report the discovery of a novel biaryl amide series as selective inhibitors of hematopoietic protein kinase 1 (HPK1). Structure–activity relationship…”
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