Search Results - "Conklyn, Maryrose J."

CP-481,715, a Potent and Selective CCR1 Antagonist with Potential Therapeutic Implications for Inflammatory Diseases by Gladue, Ronald P., Tylaska, Laurie A., Brissette, William H., Lira, Paul D., Kath, John C., Poss, Christopher S., Brown, Matthew F., Paradis, Timothy J., Conklyn, Maryrose J., Ogborne, Kevin T., McGlynn, Molly A., Lillie, Brett M., DiRico, Amy P., Mairs, Erin N., McElroy, Eric B., Martin, William H., Stock, Ingrid A., Shepard, Richard M., Showell, Henry J., Neote, Kuldeep

“…The chemokines CCL3 and CCL5, as well as their shared receptor CCR1, are believed to play a role in the pathogenesis of several inflammatory diseases including…”
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Pharmacokinetics and pharmacodynamics of the leukotriene B4 receptor antagonist CP‐105,696 in man following single oral administration by Liston, Theodore E., Conklyn, Maryrose J., Houser, Janet, Wilner, Keith D., Johnson, Arlene, Apseloff, Glen, Whitacre, Caroline, Showell, Henry J.

“…Aims  CP‐105,696, (+)‐1‐(3S,4R)‐[3‐(4‐phenylbenzyl)‐4‐hydroxy‐chroman‐7‐yl] cyclopropane carboxylic acid is a potent, novel LTB4 receptor antagonist advanced…”
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Optimization and validation of a flow cytometric method for immunophenotyping peripheral blood lymphocytes from cynomolgus monkeys (Macaca fascicularis) by Baker, D.L, Finco-Kent, D.L, Reagan, W.J, Conklyn, M.J, Kawabata, T.T

“…Background: Guidelines published by the Food and Drug Administration and Center for Human Medicinal Products describe the need to assess immunotoxic effects in…”
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Tyrosine phosphorylation is an early signaling event common to Fc receptor crosslinking in human neutrophils and rat basophilic leukemia cells (RBL-2H3) by Connelly, P A, Farrell, C A, Merenda, J M, Conklyn, M J, Showell, H J

“…Phosphotyrosine-containing proteins were detected by western blotting of whole cell lysates of purified human neutrophils or rat basophilic leukemia cells…”
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Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor by Changelian, Paul S., Flanagan, Mark E., Ball, Douglas J., Kent, Craig R., Magnuson, Kelly S., Martin, William H., Rizzuti, Bonnie J., Sawyer, Perry S., Perry, Bret D., Brissette, William H., McCurdy, Sandra P., Kudlacz, Elizabeth M., Conklyn, Maryrose J., Elliott, Eileen A., Koslov, Erika R., Fisher, Michael B., Strelevitz, Timothy J., Yoon, Kwansik, Whipple, David A., Sun, Jianmin, Munchhof, Michael J., Doty, John L., Casavant, Jeffrey M., Blumenkopf, Todd A., Hines, Michael, Brown, Matthew F., Lillie, Brett M., Subramanyam, Chakrapani, Shang-Poa, Chang, Milici, Anthony J., Beckius, Gretchen E., Moyer, James D., Su, Chunyan, Woodworth, Thasia C., Gaweco, Anderson S., Beals, Chan R., Littman, Bruce H., Fisher, Douglas A., Smith, James F., Zagouras, Panayiotis, Magna, Holly A., Saltarelli, Mary J., Johnson, Kimberly S., Nelms, Linda F., Shelley G. Des Etages, Hayes, Lisa S., Kawabata, Thomas T., Finco-Kent, Deborah, Baker, Deanna L., Larson, Michael, Si, Ming-Sing, Paniagua, Ricardo, Higgins, John, Holm, Bari, Reitz, Bruce, Zhou, Yong-Jie, Morris, Randall E., O'Shea, John J., Borie, Dominic C.

“…Because of its requirement for signaling by multiple cytokines, Janus kinase 3 (JAK3) is an excellent target for clinical immunosuppression. We report the…”
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Expression and biologic characterization of the murine chemokine KC by Bozic, CR, Kolakowski, LF, Jr, Gerard, NP, Garcia-Rodriguez, C, von Uexkull- Guldenband, C, Conklyn, MJ, Breslow, R, Showell, HJ, Gerard, C

“…KC, the product of an immediate early gene induced in mouse fibroblasts by platelet-derived growth factor, was expressed in Escherichia coli by using a maltose…”
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The Duffy antigen/receptor for chemokines (DARC) is expressed in endothelial cells of Duffy negative individuals who lack the erythrocyte receptor by Peiper, S C, Wang, Z X, Neote, K, Martin, A W, Showell, H J, Conklyn, M J, Ogborne, K, Hadley, T J, Lu, Z H, Hesselgesser, J, Horuk, R

“…The Duffy antigen/receptor for chemokines (DARC), first identified on erythrocytes, functions not only as a promiscuous chemokine receptor but also as a…”
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The murine interleukin 8 type B receptor homologue and its ligands. Expression and biological characterization by C R Bozic, N P Gerard, C von Uexkull-Guldenband, L F Kolakowski, Jr, M J Conklyn, R Breslow, H J Showell, C Gerard

“…KC, the product of an immediate early gene induced in mouse fibroblasts by platelet-derived growth factor, was synthesized as a recombinant protein in…”
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trans-3-benzyl-4-hydroxy-7-chromanylbenzoic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor by REITER, L. A, KOCH, K, DIBRINO, J. N, DOMINY, B. W, FARRELL, C. A, HINGORANI, G. P, MARTINELLI, G. J, RAMCHANDANI, M, WRIGHT, K. F, PISCOPIO, A. D, SHOWELL, H. J, ALPERT, R, BIGGERS, M. S, CHAMBERS, R. J, CONKLYN, M. J, COOPER, K, CORTINA, S. R

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In vitro and in vivo effects of leukotriene B4 antagonism in a primate model of asthma by Turner, C R, Breslow, R, Conklyn, M J, Andresen, C J, Patterson, D K, Lopez-Anaya, A, Owens, B, Lee, P, Watson, J W, Showell, H J

“…To test the hypothesis that leukotriene (LT) B4 antagonists may be clinically useful in the treatment of asthma, CP-105,696 was evaluated in vitro, using…”
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Chemokine-Dependent Upregulation of CD11b on Specific Leukocyte Subpopulations in Human Whole Blood: Effect of Anticoagulant on Rantes and MIP-1β Stimulation by Conklyn, Maryrose J., Neote, Kuldep, Showell, Henry J.

“…The effect of anticoagulant (heparin vs EDTA) on chemokine induced CD11b upregulation on neutrophils, eosinophils, and monocytes in human whole blood was…”
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Pharmacokinetics and pharmacodynamics of the leukotriene B 4 receptor antagonist CP‐105,696 in man following single oral administration by Liston, Theodore E., Conklyn, Maryrose J., Houser, Janet, Wilner, Keith D., Johnson, Arlene, Apseloff, Glen, Whitacre, Caroline, Showell, Henry J.

“…Aims  CP‐105,696, (+)‐1‐(3S,4R)‐[3‐(4‐phenylbenzyl)‐4‐hydroxy‐chroman‐7‐yl] cyclopropane carboxylic acid is a potent, novel LTB 4 receptor antagonist advanced…”
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Biological activity C-X-C and C-C chemokines on leukocyte subpopulations in human whole blood by Conklyn, M J, Showell, H J

“…We have described an assay that monitors the activating effects of a variety of chemokines on leukocyte subsets in human whole blood. This procedure has the…”
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trans-3-Benzyl-4-hydroxy-7-chromanylbenzoic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor by Reiter, L A, Koch, K, Piscopio, A D, Showell, H J, Alpert, R, Biggers, M S, Chambers, R J, Conklyn, M J, Cooper, K, Cortina, S R, Dibrino, J N, Dominy, B W, Farrell, C A, Hingorani, G P, Martinelli, G J, Ramchandani, M, Wright, K F

“…The SAR of a series of 2-(7-chromanyl)benzoic acids has been investigated with the aim of identifying potent and selective LTB4 receptor antagonists that…”
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trans-3-Benzyl-4-hydroxy-7-chromanylbenzoic acid derivatives as antagonists of the leukotriene B 4 (LTB 4) receptor by Reiter, Lawrence A., Koch, Kevin, Piscopio, Anthony D., Showell, Henry J., Alpert, Robbin, Biggers, Michael S., Chambers, Robert J., Conklyn, Maryrose J., Cooper, Kelvin, Cortina, Santo R., Dibrino, Joseph N., Dominy, Beryl W., Farrell, Cathy A., Hingorani, Gary P., Martinelli, Gary J., Ramchandani, Mukesh, Wright, Kathyrn F.

“…The SAR of a series of 2-(7-chromanyl)benzoic acids has been investigated with the aim of identifying potent and selective LTB 4 receptor antagonists that…”
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3-Substituted-4-hydroxy-7-chromanylacetic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor by REITER, L. A, MELVIN, L. S, HADA, W. A, LAIRD, E. R, MARTIN, J. J, MILLER, G. T, PILLAR, J. S, CREAN, G. L, SHOWELL, H. J, KOCH, K, BIGGERS, M. S, CHENG, J. B, BRESLOW, R, CONKLYN, M. J, FARRELL, C. A

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3-Substituted-4-hydroxy-7-chromanylacetic acid derivatives as antagonists of the leukotriene B 4 (LTB 4) receptor by Reiter, Lawrence A., Melvin, Lawrence S., Crean, Geraldine L., Showell, Henry J., Koch, Kevin, Biggers, Michael S., Cheng, John B., Breslow, Robbin, Conklyn, Maryrose J., Farrell, Cathy A., Hada, William A., Laird, Ellen R., Martin, John J., Todd Miller, G., Pillar, Joanne S.

“…The SAR of a series of 7-chromanylacetic acids has been investigated with the aim of identifying potent and selective LTB 4 receptor antagonists. We found…”
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Production and characterization of guinea pig IL-5 in baculovirus-infected insect cells by Mansour, M, Karmilowicz, M, Hawrylik, S J, Nalcerio, B, Angilly, J, Conklyn, M J, Lilly, C M, Drazen, J M, Lee, S E, Auperin, D D, De Wet, J R, Cohan, V L, Showell, H J, Danley, D E

“…To study the role interleukin (IL)-5 may play in altering airway function in asthma, we have produced recombinant protein for exogenous administration to…”
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