Search Results - "Conklin, Douglas S"

NDRG1 regulates neutral lipid metabolism in breast cancer cells by Sevinsky, Christopher J, Khan, Faiza, Kokabee, Leila, Darehshouri, Anza, Maddipati, Krishna Rao, Conklin, Douglas S

“…Altered lipid metabolism is an emerging hallmark of aggressive breast cancers. The N-myc downstream regulated gene (NDRG1) gene plays a critical role in…”
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Inertial Microfluidic Cell Stretcher (iMCS): Fully Automated, High‐Throughput, and Near Real‐Time Cell Mechanotyping by Deng, Yanxiang, Davis, Steven P., Yang, Fan, Paulsen, Kevin S., Kumar, Maneesh, Sinnott DeVaux, Rebecca, Wang, Xianhui, Conklin, Douglas S., Oberai, Assad, Herschkowitz, Jason I., Chung, Aram J.

“…Mechanical biomarkers associated with cytoskeletal structures have been reported as powerful label‐free cell state identifiers. In order to measure cell…”
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Trm9-Catalyzed tRNA Modifications Link Translation to the DNA Damage Response by Begley, Ulrike, Dyavaiah, Madhu, Patil, Ashish, Rooney, John P., DiRenzo, Dan, Young, Christine M., Conklin, Douglas S., Zitomer, Richard S., Begley, Thomas J.

“…Transcriptional and posttranslational signals are known mechanisms that promote efficient responses to DNA damage. We have identified Saccharomyces cerevisiae…”
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Bruton’s Tyrosine Kinase and Its Isoforms in Cancer by Wang, Xianhui, Kokabee, Leila, Kokabee, Mostafa, Conklin, Douglas S.

“…Bruton’s tyrosine kinase (BTK) is a soluble tyrosine kinase with central roles in the development, maturation, and signaling of B cells. BTK has been found to…”
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A novel isoform of the B cell tyrosine kinase BTK protects breast cancer cells from apoptosis by Eifert, Cheryl, Wang, Xianhui, Kokabee, Leila, Kourtidis, Antonis, Jain, Ritu, Gerdes, Michael J., Conklin, Douglas S.

“…Tyrosine kinases orchestrate key cellular signaling pathways and their dysregulation is often associated with cellular transformation. Several recent cases in…”
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Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells by Paddison, Patrick J, Caudy, Amy A, Bernstein, Emily, Hannon, Gregory J, Conklin, Douglas S

“…RNA interference (RNAi) was first recognized in Caenorhabditis elegans as a biological response to exogenous double-stranded RNA (dsRNA), which induces…”
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Dual function of pancreatic endoplasmic reticulum kinase in tumor cell growth arrest and survival by Ranganathan, Aparna C, Ojha, Shishir, Kourtidis, Antonis, Conklin, Douglas S, Aguirre-Ghiso, Julio A

“…Pancreatic endoplasmic reticulum kinase (PERK)-eIF2 alpha signaling, a component of the endoplasmic reticulum (ER) stress response, has been proposed as a…”
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High-throughput selection of effective RNAi probes for gene silencing by Kumar, Rajeev, Conklin, Douglas S, Mittal, Vivek

“…RNA interference (RNAi) is a process of sequence-specific posttranscriptional gene silencing mediated by double-stranded RNA. RNAi has recently emerged as a…”
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Lipid biology of breast cancer by Baumann, Jan, Sevinsky, Christopher, Conklin, Douglas S.

“…Alterations in lipid metabolism have been reported in many types of cancer. Lipids have been implicated in the regulation of proliferation, differentiation,…”
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Palmitate-induced ER stress increases trastuzumab sensitivity in HER2/neu-positive breast cancer cells by Baumann, Jan, Wong, Jason, Sun, Yan, Conklin, Douglas S

“…HER2/neu-positive breast cancer cells have recently been shown to use a unique Warburg-like metabolism for survival and aggressive behavior. These cells…”
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Bruton's Tyrosine Kinase Inhibitors Prevent Therapeutic Escape in Breast Cancer Cells by Wang, Xianhui, Wong, Jason, Sevinsky, Christopher J, Kokabee, Leila, Khan, Faiza, Sun, Yan, Conklin, Douglas S

“…We have reported that a novel isoform of BTK (BTK-C) expressed in breast cancer protects these cells from apoptosis. In this study, we show that recently…”
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Palmitoylation of the Alternative Amino Terminus of the BTK-C Isoform Controls Subcellular Distribution and Signaling by KOKABEE, MOSTAFA, WANG, XIANHUI, VOORAND, ELENA, ALIN, EDEN, KOKABEE, LEILA, KHAN, FAIZA, DESROSIERS, SOPHIA, CONKLIN, DOUGLAS S.

“…Background: The alternative transcriptional isoform of Bruton's tyrosine kinase, BTK-C, is expressed in a wide variety of epithelial tumor types where it…”
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RNA Science and its Applications—a look toward the future: Albany, NY USA, November 3–4, 2011 by Breaker, Ronald R, Conklin, Douglas S, Gold, Larry, Söll, Dieter, Montimurro, Jennifer S, Agris, Paul F

“…On November 3–4, 2010, the Symposium RNA Science and its Applications: A look toward the Future was held at the University at Albany-SUNY in the capital of New…”
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Bruton's tyrosine kinase is a potential therapeutic target in prostate cancer by Kokabee, Leila, Wang, Xianhui, Sevinsky, Christopher J, Wang, Wei Lin Winnie, Cheu, Lindsay, Chittur, Sridar V, Karimipoor, Morteza, Tenniswood, Martin, Conklin, Douglas S

“…Bruton's tyrosine kinase (BTK) is a non-receptor tyrosine kinase that has mainly been studied in haematopoietic cells. We have investigated whether BTK is a…”
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Computational Identification of a p38SAPK -Regulated Transcription Factor Network Required for Tumor Cell Quiescence by ADAM, Alejandro P, GEORGE, Ajish, SCHEWE, Denis, BRAGADO, Paloma, IGLESIAS, Bibiana V, RANGANATHAN, Aparna C, KOURTIDIS, Antonis, CONKLIN, Douglas S, AGUIRRE-GHISO, Julio A

“…The stress-activated kinase p38 plays key roles in tumor suppression and induction of tumor cell dormancy. However, the mechanisms behind these functions…”
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Global metabolite profiling analysis of lipotoxicity in HER2/neu-positive breast cancer cells by Baumann, Jan, Kokabee, Mostafa, Wong, Jason, Balasubramaniyam, Rakshika, Sun, Yan, Conklin, Douglas S

“…Recent work has shown that HER2/neu-positive breast cancer cells rely on a unique Warburg-like metabolism for survival and aggressive behavior. These cells are…”
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RNA interference in adult mice by McCaffrey, Anton P, Meuse, Leonard, Pham, Thu-Thao T, Conklin, Douglas S, Hannon, Gregory J, Kay, Mark A

“…RNA interference is an evolutionarily conserved surveillance mechanism that responds to double-stranded RNA by sequence-specific silencing of homologous genes…”
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An RNA Interference Screen Identifies Metabolic Regulators NR1D1 and PBP as Novel Survival Factors for Breast Cancer Cells with the ERBB2 Signature by KOURTIDIS, Antonis, JAIN, Ritu, CARKNER, Richard D, EIFERT, Cheryl, BROSNAN, M. Julia, CONKLIN, Douglas S

“…Overexpression of the adverse prognostic marker ERBB2 occurs in 30% of breast cancers; however, therapies targeting this gene have not proved to be as…”
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MaRX: An Approach to Genetics in Mammalian Cells by Hannon, Gregory J., Sun, Peiqing, Carnero, Amancio, Xie, Lin Ying, Maestro, Roberta, Conklin, Douglas S., Beach, David

“…Hannon et al sought to apply genetic methods to mammals or their manipulable surrogates, cultured mammalian cells. Rather than creating a genetic methodology…”
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A resource for large-scale RNA-interference-based screens in mammals by Hannon, Gregory J, Paddison, Patrick J, Silva, Jose M, Conklin, Douglas S, Schlabach, Mike, Li, Mamie, Aruleba, Shola, Balija, Vivekanand, O'Shaughnessy, Andy, Gnoj, Lidia, Scobie, Kim, Chang, Kenneth, Westbrook, Thomas, Cleary, Michele, Sachidanandam, Ravi, Richard McCombie, W, Elledge, Stephen J

“…Gene silencing by RNA interference (RNAi) in mammalian cells using small interfering RNAs (siRNAs) and short hairpin RNAs (shRNAs) has become a valuable…”
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