Search Results - "Conklin, B. R"

Validated assays for the quantification of C9orf72 human pathology by Salomonsson, S. E., Maltos, A. M., Gill, K., Aladesuyi Arogundade, O., Brown, K. A., Sachdev, A., Sckaff, M., Lam, K. J. K., Fisher, I. J., Chouhan, R. S., Van Laar, V. S., Marley, C. B., McLaughlin, I., Bankiewicz, K. S., Tsai, Y.-C., Conklin, B. R., Clelland, C. D.

“…A repeat expansion mutation in the C9orf72 gene is the leading known genetic cause of FTD and ALS. The C9orf72- ALS/FTD field has been plagued by a lack of…”
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Conditional Expression of a Gi-Coupled Receptor in Osteoblasts Results in Trabecular Osteopenia by Peng, J, Bencsik, M, Louie, A, Lu, W, Millard, S, Nguyen, P, Burghardt, A, Majumdar, S, Wronski, T. J, Halloran, B, Conklin, B. R, Nissenson, R. A

“…G protein-coupled receptors (GPCRs) coupled to activation of Gs, such as the PTH1 receptor (PTH1R), have long been known to regulate skeletal function and…”
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WikiPathways: building research communities on biological pathways by Kelder, Thomas, van Iersel, Martijn P., Hanspers, Kristina, Kutmon, Martina, Conklin, Bruce R., Evelo, Chris T., Pico, Alexander R.

“…Here, we describe the development of WikiPathways (http://www.wikipathways.org), a public wiki for pathway curation, since it was first published in 2008. New…”
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Identification of a Receptor/G-Protein Contact Site Critical for Signaling Specificity and G-Protein Activation by Liu, Jie, Conklin, Bruce R., Blin, Nathalie, Yun, June, Wess, Jurgen

“…Each G protein-coupled receptor recognizes only a distinct subset of the many structurally closely related G proteins expressed within a cell. How this…”
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Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C by Conklin, B R, Chabre, O, Wong, Y H, Federman, A D, Bourne, H R

“…Gq mediates hormonal stimulation of phosphoinositide-specific phospholipase C (PI-PLC). We mutated the alpha subunit of Gq (alpha q) to replace arginine 183…”
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Gz-mediated hormonal inhibition of cyclic AMP accumulation by WONG, Y. H, CONKLIN, B. R, BOURNE, H. R

“…Hormones inhibit synthesis of adenosine 3',5'-monophosphate (cAMP) in most cells via receptors coupled to pertussis toxin (PTX)-sensitive guanine…”
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Stimulation of Arachidonic Acid Release and Inhibition of Mitogenesis by Cloned Genes for Muscarinic Receptor Subtypes Stably Expressed in A9 L Cells by Conklin, Bruce R., Brann, Mark R., Buckley, Noel J., Ma, Alice L., Bonner, Tom I., Axelrod, Julius

“…A family of genes encoding four distinct muscarinic receptors (designated m1-m4) has been cloned and stably expressed in A9 L cells. When the m1 and m3…”
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G alpha 13 stimulates Na-H exchange by Voyno-Yasenetskaya, T., Conklin, B.R., Gilbert, R.L., Hooley, R., Bourne, H.R., Barber, D.L.

“…Activity of the ubiquitous Na-H exchanger (NHE1) is regulated by a number of receptors with tyrosine kinase activity as well as by several classes of receptors…”
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Type II adenylylcyclase integrates coincident signals from Gs, Gi, and Gq by Lustig, K D, Conklin, B R, Herzmark, P, Taussig, R, Bourne, H R

“…Agonists for Gi-coupled receptors augment Gs-stimulated cAMP synthesis in human embryonic kidney (HEK) 293 cells transiently expressing the type II isozyme of…”
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Tetracycline-Inducible System for Photoreceptor-Specific Gene Expression by Chang, Michelle A, Horner, James W, Conklin, Bruce R, DePinho, Ronald A, Bok, Dean, Zack, Donald J

“…To develop a system for inducible photoreceptor-specific gene expression in transgenic mice. The tetracycline regulatory system was chosen because it possesses…”
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A recombinant calcitonin receptor independently stimulates 3',5'-cyclic adenosine monophosphate and Ca2+/inositol phosphate signaling pathways by Chabre, O, Conklin, B R, Lin, H Y, Lodish, H F, Wilson, E, Ives, H E, Catanzariti, L, Hemmings, B A, Bourne, H R

“…Calcitonin (CT), a polypeptide hormone, regulates calcium homeostasis by activating surface receptors coupled to stimulation of adenylyl cyclase in bone and…”
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Mineral composition is altered by osteoblast expression of an engineered G(s)-coupled receptor by Kazakia, G J, Speer, D, Shanbhag, S, Majumdar, S, Conklin, B R, Nissenson, R A, Hsiao, E C

“…Activation of the G(s) G protein-coupled receptor Rs1 in osteoblasts increases bone mineral density by 5- to 15-fold in mice and recapitulates histologic…”
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Distinct bradykinin receptors mediate stimulation of prostaglandin synthesis by endothelial cells and fibroblasts by Conklin, B R, Burch, R M, Steranka, L R, Axelrod, J

“…Bradykinin-stimulated prostaglandin synthesis was investigated in Swiss albino 3T3 fibroblasts (Swiss 3T3 cells) and bovine pulmonary artery endothelial cells…”
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Regression approaches for microarray data analysis by Segal, Mark R, Dahlquist, Kam D, Conklin, Bruce R

“…A variety of new procedures have been devised to handle the two-sample comparison (e.g., tumor versus normal tissue) of gene expression values as measured with…”
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Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors by Conklin, B R, Bourne, H R

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Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunits by Federman, A D, Conklin, B R, Schrader, K A, Reed, R R, Bourne, H R

“…Agonist-bound receptors activate heterotrimeric (alpha beta gamma) G proteins by catalysing replacement by GTP of GDP bound to the alpha subunit, resulting in…”
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Interactions of Muscarinic Receptors with the Heterotrimeric G Proteins Gq and G12: Transduction of Proliferative Signals by Burstein, E. S., Bräuner‐Osborne, H., Spalding, T. A., Conklin, B. R., Brann, M. R.

“…: The proliferative and transforming properties of m2 and m5 muscarinic acetylcholine receptors and a series of wild‐type, chimeric, and mutant G proteins were…”
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Molecular basis of receptor/G protein coupling selectivity studied by coexpression of wild type and mutant m2 muscarinic receptors with mutant G alpha(q) subunits by Kostenis, E, Conklin, B R, Wess, J

“…The molecular basis of receptor/G protein coupling selectivity was studied by using the m2 muscarinic receptor, a prototypical G(i/o)-coupled receptor as a…”
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Engineering receptors activated solely by synthetic ligands (RASSLs) by Scearce-Levie, Kimberly, Coward, Peter, Redfern, Charles H., Conklin, Bruce R.

“…The functional and molecular diversity of G-protein-coupled receptors presents a significant challenge to understanding the connection between a single…”
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Interfacing Silicon Nanowires with Mammalian Cells by Kim, Woong, Ng, Jennifer K, Kunitake, Miki E, Conklin, Bruce R, Yang, Peidong

“…We present the first demonstration of a direct interface of silicon nanowires with mammalian cells such as mouse embryonic stem (mES) cells and human embryonic…”
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