Search Results - "Conine, Colin C."

Small RNAs Are Trafficked from the Epididymis to Developing Mammalian Sperm by Sharma, Upasna, Sun, Fengyun, Conine, Colin C., Reichholf, Brian, Kukreja, Shweta, Herzog, Veronika A., Ameres, Stefan L., Rando, Oliver J.

“…The biogenesis of the RNA payload of mature sperm is of great interest, because RNAs delivered to the zygote at fertilization can affect early development…”
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Small RNAs Gained during Epididymal Transit of Sperm Are Essential for Embryonic Development in Mice by Conine, Colin C., Sun, Fengyun, Song, Lina, Rivera-Pérez, Jaime A., Rando, Oliver J.

“…The small RNA payload of mammalian sperm undergoes dramatic remodeling during development, as several waves of microRNAs and tRNA fragments are shipped to…”
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Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals by Sharma, Upasna, Conine, Colin C., Shea, Jeremy M., Boskovic, Ana, Derr, Alan G., Bing, Xin Y., Belleannee, Clemence, Kucukural, Alper, Serra, Ryan W., Sun, Fengyun, Song, Lina, Carone, Benjamin R., Ricci, Emiliano P., Li, Xin Z., Fauquier, Lucas, Moore, Melissa J., Sullivan, Robert, Mello, Craig C., Garber, Manuel, Rando, Oliver J.

“…Several recent studies link parental environments to phenotypes in subsequent generations. In this work, we investigate the mechanism by which paternal diet…”
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Epididymal acquired sperm microRNAs modify post-fertilization embryonic gene expression by Trigg, Natalie A., Conine, Colin C.

“…Sperm small RNAs have emerged as important non-genetic contributors to embryogenesis and offspring health. A subset of sperm small RNAs is thought to be…”
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Stability of the cytosine methylome during post-testicular sperm maturation in mouse by Galan, Carolina, Serra, Ryan W, Sun, Fengyun, Rinaldi, Vera D, Conine, Colin C, Rando, Oliver J

“…Beyond the haploid genome, mammalian sperm carry a payload of epigenetic information with the potential to modulate offspring phenotypes. Recent studies show…”
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The Transmission of Intergenerational Epigenetic Information by Sperm microRNAs by Lee, Grace S, Conine, Colin C

“…Epigenetic information is transmitted from one generation to the next, modulating the phenotype of offspring non-genetically in organisms ranging from plants…”
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MicroRNAs Absent in Caput Sperm Are Required for Normal Embryonic Development by Conine, Colin C., Sun, Fengyun, Song, Lina, Rivera-Pérez, Jaime A., Rando, Oliver J.

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Sperm Head Preparation and Genetic Background Affect Caput Sperm ICSI Embryo Viability: Cauda-Enriched miRNAs Only Essential in Specific Conditions by Conine, Colin C, Sun, Fengyun, Song, Lina, Rivera-Pérez, Jaime A, Rando, Oliver J

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Argonautes ALG-3 and ALG-4 are required for spermatogenesis-specific 26G-RNAs and thermotolerant sperm in Caenorhabditis elegans by Conine, Colin C, Batista, Pedro J, Gu, Weifeng, Claycomb, Julie M, Chaves, Daniel A, Shirayama, Masaki, Mello, Craig C

“…Gametogenesis is a thermosensitive process in numerous metazoans, ranging from worms to man. In Caenorhabditis elegans, a variety of RNA-binding proteins that…”
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The microbiota and T cells non-genetically modulate inherited phenotypes transgenerationally by Harris, Jordan C., Trigg, Natalie A., Goshu, Bruktawit, Yokoyama, Yuichi, Dohnalová, Lenka, White, Ellen K., Harman, Adele, Murga-Garrido, Sofía M., Ting-Chun Pan, Jamie, Bhanap, Preeti, Thaiss, Christoph A., Grice, Elizabeth A., Conine, Colin C., Kambayashi, Taku

“…The host-microbiota relationship has evolved to shape mammalian physiology, including immunity, metabolism, and development. Germ-free models are widely used…”
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Argonautes Promote Male Fertility and Provide a Paternal Memory of Germline Gene Expression in C. elegans by Conine, Colin C., Moresco, James J., Gu, Weifeng, Shirayama, Masaki, Conte, Darryl, Yates, John R., Mello, Craig C.

“…During each life cycle, germ cells preserve and pass on both genetic and epigenetic information. In C. elegans, the ALG-3/4 Argonaute proteins are expressed…”
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Effects of Larval Density on Gene Regulation in Caenorhabditis elegans During Routine L1 Synchronization by Chan, Io Long, Rando, Oliver J, Conine, Colin C

“…Bleaching gravid followed by a short period of starvation of the L1 larvae is a routine method performed by worm researchers for generating synchronous…”
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Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network by Walhout, Albertha J M, Arda, H Efsun, Taubert, Stefan, MacNeil, Lesley T, Conine, Colin C, Tsuda, Ben, Van Gilst, Marc, Sequerra, Reynaldo, Doucette-Stamm, Lynn, Yamamoto, Keith R

“…Gene regulatory networks (GRNs) provide insights into the mechanisms of differential gene expression at a systems level. GRNs that relate to metazoan…”
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Soma-to-germline RNA communication by Conine, Colin C., Rando, Oliver J.

“…More than a century ago, August Weissman defined a distinction between the germline (responsible for propagating heritable information from generation to…”
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Subchronic elevation in ambient temperature drives alterations to the sperm epigenome and accelerates early embryonic development in mice by Trigg, Natalie, Schjenken, John E., Martin, Jacinta H., Skerrett-Byrne, David A., Smyth, Shannon P., Bernstein, Ilana R., Anderson, Amanda L., Stanger, Simone J., Simpson, Ewan N. A., Tomar, Archana, Teperino, Raffaele, Conine, Colin C., De Iuliis, Geoffry N., Roman, Shaun D., Bromfield, Elizabeth G., Dun, Matthew D., Eamens, Andrew L., Nixon, Brett

“…Forecasted increases in the prevalence and severity of extreme weather events accompanying changes in climatic behavior pose potential risk to the reproductive…”
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