Search Results - "Coney, Andrew"

Editorial: Mitochondrial sensitivity of sensory neurons controlling breathing by Jendzjowsky, Nicholas, Coney, Andrew M.

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Lung function and breathing patterns in hospitalised COVID-19 survivors: a review of post-COVID-19 Clinics by Stockley, James A, Alhuthail, Eyas A, Coney, Andrew M, Parekh, Dhruv, Geberhiwot, Tarekegn, Gautum, Nandan, Madathil, Shyam C, Cooper, Brendan G

“…There is relatively little published on the effects of COVID-19 on respiratory physiology, particularly breathing patterns. We sought to determine if there…”
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Prenatal Hypoxia Leads to Increased Muscle Sympathetic Nerve Activity, Sympathetic Hyperinnervation, Premature Blunting of Neuropeptide Y Signaling, and Hypertension in Adult Life by Rook, William, Johnson, Christopher D, Coney, Andrew M, Marshall, Janice M

“…Adverse conditions prenatally increase the risk of cardiovascular disease, including hypertension. Chronic hypoxia in utero (CHU) causes endothelial…”
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Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development by Phillips, Tom J., Scott, Hannah, Menassa, David A., Bignell, Ashleigh L., Sood, Aman, Morton, Jude S., Akagi, Takami, Azuma, Koki, Rogers, Mark F., Gilmore, Catherine E., Inman, Gareth J., Grant, Simon, Chung, Yealin, Aljunaidy, Mais M., Cooke, Christy-Lynn, Steinkraus, Bruno R., Pocklington, Andrew, Logan, Angela, Collett, Gavin P., Kemp, Helena, Holmans, Peter A., Murphy, Michael P., Fulga, Tudor A., Coney, Andrew M., Akashi, Mitsuru, Davidge, Sandra T., Case, C. Patrick

“…Some neuropsychiatric disease, including schizophrenia, may originate during prenatal development, following periods of gestational hypoxia and placental…”
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Ecto‐5′‐nucleotidase (CD73) regulates peripheral chemoreceptor activity and cardiorespiratory responses to hypoxia by Holmes, Andrew P., Ray, Clare J., Pearson, Selina A., Coney, Andrew M., Kumar, Prem

“…Key points Carotid body dysfunction is recognized as a cause of hypertension in a number of cardiorespiratory diseases states and has therefore been identified…”
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G-Protein-Coupled Receptor (GPCR) Signaling in the Carotid Body: Roles in Hypoxia and Cardiovascular and Respiratory Disease by Aldossary, Hayyaf S, Alzahrani, Abdulaziz A, Nathanael, Demitris, Alhuthail, Eyas A, Ray, Clare J, Batis, Nikolaos, Kumar, Prem, Coney, Andrew M, Holmes, Andrew P

“…The carotid body (CB) is an important organ located at the carotid bifurcation that constantly monitors the blood supplying the brain. During hypoxia, the CB…”
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A student practical to conceptualize the importance of Poiseuille’s law and flow control in the cardiovascular system by Holmes, Andrew P., Ray, Clare J., Kumar, Prem, Coney, Andrew M.

“…The laboratory practical reported here is based in Poiseuille’s law and utilizes low-cost laboratory consumable items, thereby making it easy to deploy in any…”
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Mechanisms of Atrial Fibrillation in Obstructive Sleep Apnoea by Saleeb-Mousa, James, Nathanael, Demitris, Coney, Andrew M, Kalla, Manish, Brain, Keith L, Holmes, Andrew P

“…Obstructive sleep apnoea (OSA) is a strong independent risk factor for atrial fibrillation (AF). Emerging clinical data cite adverse effects of OSA on AF…”
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Adrenaline release evokes hyperpnoea and an increase in ventilatory CO2 sensitivity during hypoglycaemia: a role for the carotid body by Thompson, Emma L., Ray, Clare J., Holmes, Andrew P., Pye, Richard L., Wyatt, Christopher N., Coney, Andrew M., Kumar, Prem

“…Key points Hypoglycaemia is counteracted by release of hormones and an increase in ventilation and CO2 sensitivity to restore blood glucose levels and prevent…”
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Are Multiple Mitochondrial Related Signalling Pathways Involved in Carotid Body Oxygen Sensing? by Holmes, Andrew P, Swiderska, Agnieszka, Nathanael, Demitris, Aldossary, Hayyaf S, Ray, Clare J, Coney, Andrew M, Kumar, Prem

“…It is generally acknowledged that the carotid body (CB) type I cell mitochondria are unique, being inhibited by relatively small falls in P O well above those…”
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Adrenaline activation of the carotid body: Key to CO2 and pH homeostasis in hypoglycaemia and potential pathological implications in cardiovascular disease by Holmes, Andrew P., Ray, Clare J., Thompson, Emma L., Alshehri, Ziyad, Coney, Andrew M., Kumar, Prem

“…•Carotid body activation during hypoglycaemia is essential for hyperpnoea thereby protecting against a rise in CO2 and systemic acidosis.•Our recent findings…”
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Measurement of breathing in patients with post-COVID-19 using structured light plethysmography (SLP) by Alhuthail, Eyas, Stockley, James, Coney, Andrew, Cooper, Brendan

“…IntroductionCOVID-19 pandemic has had a huge impact on global health to date, with 5.6 million cases in the UK since its emergence. The respiratory symptoms…”
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Is Carotid Body Physiological O 2 Sensitivity Determined by a Unique Mitochondrial Phenotype? by Holmes, Andrew P, Ray, Clare J, Coney, Andrew M, Kumar, Prem

“…The mammalian carotid body (CB) is the primary arterial chemoreceptor that responds to acute hypoxia, initiating systemic protective reflex responses that act…”
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β-Adrenoceptor blockade prevents carotid body hyperactivity and elevated vascular sympathetic nerve density induced by chronic intermittent hypoxia by Alzahrani, Abdulaziz A., Cao, Lily L., Aldossary, Hayyaf S., Nathanael, Demitris, Fu, Jiarong, Ray, Clare J., Brain, Keith L., Kumar, Prem, Coney, Andrew M., Holmes, Andrew P.

“…Carotid body (CB) hyperactivity promotes hypertension in response to chronic intermittent hypoxia (CIH). The plasma concentration of adrenaline is reported to…”
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Is Carotid Body Physiological O2 Sensitivity Determined by a Unique Mitochondrial Phenotype? by Holmes, Andrew P., Ray, Clare J., Coney, Andrew M., Kumar, Prem

“…The mammalian carotid body (CB) is the primary arterial chemoreceptor that responds to acute hypoxia, initiating systemic protective reflex responses that act…”
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Mitochondrial Succinate Metabolism and Reactive Oxygen Species Are Important but Not Essential for Eliciting Carotid Body and Ventilatory Responses to Hypoxia in the Rat by Swiderska, Agnieszka, Coney, Andrew M., Alzahrani, Abdulaziz A., Aldossary, Hayyaf S., Batis, Nikolaos, Ray, Clare J., Kumar, Prem, Holmes, Andrew P.

“…Reflex increases in breathing in response to acute hypoxia are dependent on activation of the carotid body (CB)—A specialised peripheral chemoreceptor. Central…”
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Mild Chronic Intermittent Hypoxia in Wistar Rats Evokes Significant Cardiovascular Pathophysiology but No Overt Changes in Carotid Body-Mediated Respiratory Responses by Ray, Clare J, Dow, Ben, Kumar, Prem, Coney, Andrew M

“…Models of chronic intermittent hypoxia (CIH), the main feature of obstructive sleep apnoea (OSA), have demonstrated dysregulation of the cardiovascular and…”
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Effects of maternal hypoxia on muscle vasodilatation evoked by acute systemic hypoxia in adult rat offspring: changed roles of adenosine and A1 receptors by Coney, Andrew M., Marshall, Janice M.

“…Suboptimal conditions in utero can have long‐lasting effects including increased risk of cardiovascular disease in adult life. Such programming effects may be…”
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Both substrate availability and utilisation contribute to the defence of core temperature in response to acute cold by Hauton, David, Coney, Andrew M., Egginton, Stuart

“…Acute cooling significantly increases energy demand in non-hibernators for the defence of core temperature but the contribution of the liver to thermogenesis…”
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Interactions of adenosine, prostaglandins and nitric oxide in hypoxia-induced vasodilatation: in vivo and in vitro studies by Ray, Clare J., Abbas, Mark R., Coney, Andrew M., Marshall, Janice M.

“…Adenosine, prostaglandins (PG) and nitric oxide (NO) have all been implicated in hypoxia-evoked vasodilatation. We investigated whether their actions are…”
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