Search Results - "Condliffe, Steven B."

LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool by Piccoli, Giovanni, Condliffe, Steven B, Bauer, Matthias, Giesert, Florian, Boldt, Karsten, De Astis, Silvia, Meixner, Andrea, Sarioglu, Hakan, Vogt-Weisenhorn, Daniela M, Wurst, Wolfgang, Gloeckner, Christian Johannes, Matteoli, Michela, Sala, Carlo, Ueffing, Marius

“…Mutations in leucine-rich repeat kinase 2 (LRRK2) are the single most common cause of inherited Parkinson's disease. Little is known about its involvement in…”
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Plasma membrane insertion of KCa2.3 (SK3) is dependent upon the SNARE proteins, syntaxin-4 and SNAP23 by Bertuccio, Claudia A, Wang, Tony T, Hamilton, Kirk L, Rodriguez-Gil, Diego J, Condliffe, Steven B, Devor, Daniel C

“…We previously demonstrated endocytosis of KCa2.3 is caveolin-1-, dynamin II- and Rab5-dependent. KCa2.3 then enters Rab35/EPI64C- and RME-1-containing…”
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Annexin II Light Chain p11 Interacts With ENaC to Increase Functional Activity at the Membrane by Cheung, Tanya T, Ismail, Noor A S, Moir, Rachel, Arora, Nikhil, McDonald, Fiona J, Condliffe, Steven B

“…The epithelial Na channel (ENaC) provides for Na absorption in various types of epithelia including the kidney, lung, and colon where ENaC is localized to the…”
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Inactivation kinetics of voltage-gated calcium channels in glutamatergic neurons are influenced by SNAP-25 by Condliffe, Steven B., Matteoli, Michela

“…SNAP-25 forms part of the SNARE core complex that mediates membrane fusion. Biochemical and electrophysiological evidence supports an accessory role for…”
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Syntaxin 1A Regulates ENaC Channel Activity by Condliffe, Steven B., Zhang, Hui, Frizzell, Raymond A.

“…Na+ entry across the apical membranes of many absorptive epithelia is determined by the number (N) and open probability (Po) of epithelial sodium channels…”
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Cysteine String Protein Monitors Late Steps in Cystic Fibrosis Transmembrane Conductance Regulator Biogenesis by Zhang, Hui, Schmidt, Bela Z., Sun, Fei, Condliffe, Steven B., Butterworth, Michael B., Youker, Robert T., Brodsky, Jeffrey L., Aridor, Meir, Frizzell, Raymond A.

“…We examined the role of the cysteine string protein (Csp) in cystic fibrosis transmembrane conductance regulator (CFTR) biogenesis in relation to another…”
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Endogenous SNAP-25 Regulates Native Voltage-gated Calcium Channels in Glutamatergic Neurons by Condliffe, Steven B., Corradini, Irene, Pozzi, Davide, Verderio, Claudia, Matteoli, Michela

“…In addition to its primary role as a fundamental component of the SNARE complex, SNAP-25 also modulates voltage-gated calcium channels (VGCCs) in various…”
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LRRK2 Regulates Voltage-Gated Calcium Channel Function by Bedford, Cade, Sears, Catherine, Perez-Carrion, Maria, Piccoli, Giovanni, Condliffe, Steven B

“…Voltage-gated Ca(2+) (CaV) channels enable Ca(2+) influx in response to membrane depolarization. CaV2.1 channels are localized to the presynaptic membrane of…”
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Syntaxin 1A Regulates ENaC via Domain-specific Interactions by Condliffe, Steven B, Carattino, Marcelo D, Frizzell, Raymond A, Zhang, Hui

“…The epithelial sodium channel (ENaC) is a heterotrimeric protein responsible for Na + absorption across the apical membranes of several absorptive epithelia…”
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Mutant PrP suppresses glutamatergic neurotransmission in cerebellar granule neurons by impairing membrane delivery of VGCC α(2)δ-1 Subunit by Senatore, Assunta, Colleoni, Simona, Verderio, Claudia, Restelli, Elena, Morini, Raffaella, Condliffe, Steven B, Bertani, Ilaria, Mantovani, Susanna, Canovi, Mara, Micotti, Edoardo, Forloni, Gianluigi, Dolphin, Annette C, Matteoli, Michela, Gobbi, Marco, Chiesa, Roberto

“…How mutant prion protein (PrP) leads to neurological dysfunction in genetic prion diseases is unknown. Tg(PG14) mice synthesize a misfolded mutant PrP which is…”
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The E1015K Variant in the Synprint Region of the CaV2.1 Channel Alters Channel Function and Is Associated with Different Migraine Phenotypes by Condliffe, Steven B., Fratangeli, Alessandra, Munasinghe, Nehan R., Saba, Elena, Passafaro, Maria, Montrasio, Cristina, Ferrari, Maurizio, Rosa, Patrizia, Carrera, Paola

“…Mutations in the CACNA1A gene, which encodes the pore-forming α1A subunit of the CaV2.1 voltage-gated calcium channel, cause a number of human neurologic…”
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Chaperone displacement from mutant cystic fibrosis transmembrane conductance regulator restores its function in human airway epithelia by Sun, Fei, Mi, Zhibao, Condliffe, Steven B, Bertrand, Carol A, Gong, Xiaoyan, Lu, Xiaoli, Zhang, Ruilin, Latoche, Joseph D, Pilewski, Joseph M, Robbins, Paul D, Frizzell, Raymond A

“…Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF). The most common mutation, ΔF508, omits the…”
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17β‐Oestradiol acutely regulates Cl− secretion in rat distal colonic epithelium by Condliffe, Steven B., Doolan, Christina M., Harvey, Brian J.

“…1 In this study we used the short circuit current (ISC) technique to measure the non‐genomic effects of the female sex steroid 17β‐oestradiol (E2) on…”
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Non-genomic convergent and divergent signalling of rapid responses to aldosterone and estradiol in mammalian colon by Harvey, Brian J., Doolan, Christina M., Condliffe, Steven B., Renard, Celine, Alzamora, Rodrigo, Urbach, Valerie

“…Studies from our laboratory have demonstrated rapid ( < 1 min) non-genomic activation of Na +-H + exchange, K + recycling, PKC activity and a PKC-dependent Ca…”
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Plasma membrane insertion of KCa2.3 by Bertuccio, Claudia A, Wang, Tony T, Hamilton, Kirk L, Rodriguez-Gil, Diego J, Condliffe, Steven B, Devor, Daniel C

“…We previously demonstrated endocytosis of KCa2.3 is caveolin-1-, dynamin II- and Rab5-dependent. KCa2.3 then enters Rab35/EPI64C- and RME-1-containing…”
Get full text

Mutant PrP Suppresses Glutamatergic Neurotransmission in Cerebellar Granule Neurons by Impairing Membrane Delivery of VGCC [alpha]2[delta]-1 Subunit by Senatore, Assunta, Colleoni, Simona, Verderio, Claudia, Restelli, Elena, Morini, Raffaella, Condliffe, Steven B, Bertani, Ilaria, Mantovan i, Susanna, Canovi, Mara, Micotti, Edoardo, loni, Gianluigi, Dolphin, Annette C, Matteoli, Michela, Gobbi, Marco, Chiesa, Roberto

“…How mutant prion protein (PrP) leads to neurological dysfunction in genetic prion diseases is unknown. Tg(PG14) mice synthesize a misfolded mutant PrP which is…”
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Mutant PrP Suppresses Glutamatergic Neurotransmission in Cerebellar Granule Neurons by Impairing Membrane Delivery of VGCC α2δ-1 Subunit by Senatore, Assunta, Colleoni, Simona, Verderio, Claudia, Restelli, Elena, Morini, Raffaella, Condliffe, Steven B., Bertani, Ilaria, Mantovani, Susanna, Canovi, Mara, Micotti, Edoardo, Forloni, Gianluigi, Dolphin, Annette C., Matteoli, Michela, Gobbi, Marco, Chiesa, Roberto

“…How mutant prion protein (PrP) leads to neurological dysfunction in genetic prion diseases is unknown. Tg(PG14) mice synthesize a misfolded mutant PrP which is…”
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Mutant PrP Suppresses Glutamatergic Neurotransmission in Cerebellar Granule Neurons by Impairing Membrane Delivery of VGCC alpha 2 delta -1 Subunit by Senatore, Assunta, Colleoni, Simona, Verderio, Claudia, Restelli, Elena, Morini, Raffaella, Condliffe, Steven B, Bertani, Ilaria, Mantovani, Susanna, Canovi, Mara, Micotti, Edoardo, loni, Gianluigi, Dolphin, Annette C, Matteoli, Michela, Gobbi, Marco, Chiesa, Roberto

“…How mutant prion protein (PrP) leads to neurological dysfunction in genetic prion diseases is unknown. Tg(PG14) mice synthesize a misfolded mutant PrP which is…”
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17β-Oestradiol acutely regulates Cl− secretion in rat distal colonic epithelium by Steven B Condliffe, Christina M Doolan, Brian J Harvey

“…In this study we used the short circuit current ( I SC ) technique to measure the non-genomic effects of the female sex steroid 17β-oestradiol (E 2 ) on…”
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Rapid non-genomic activation of cytosolic cyclic AMP-dependent protein kinase activity and [Ca2+]i by 17[beta]-oestradiol in female rat distal colon by Doolan, Christina M, Condliffe, Steven B, Harvey, Brian J

“…1. In this study, the effect of 17beta-oestradiol on adenosine 3' : 5'-cyclic monophosphate (cyclic AMP)-dependent protein kinase (PKA) activity was…”
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