Search Results - "Conder, Mary Lee"

Estimation of hERG inhibition of drug candidates using multivariate property and pharmacophore SAR by Johnson, Stephen R., Yue, Hongwen, Conder, Mary Lee, Shi, Hong, Doweyko, Arthur M., Lloyd, John, Levesque, Paul

“…We describe the development and validation of an in silico model of hERG inhibition. The model includes several factors not previously reported for the…”
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Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective Kv1.5 blockers by LLOYD, John, FINLAY, Heather J, HONG SHI, HUANG, Christine, DANSHI LI, HUABIN SUN, LEVESQUE, Paul, VACARRO, Wayne, HYUNH, Tram, KOVER, Alexander, BHANDARU, Rao, LIN YAN, ATWAL, Karnail, LEE CONDER, Mary, JENKINS-WEST, Tonya

“…Design and synthesis of pyrazolodihydropyrimidines as KV1.5 blockers led to the discovery of 7d as a potent and selective antagonist. This compound showed…”
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Dihydropyrazolopyrimidine Inhibitors of Kv1.5 (IKur) by VACCARO, Wayne, HUYNH, Tram, LLOYD, John, ATWAL, Karnail, FINLAY, Heather J, LEVESQUE, Paul, LEE CONDER, Mary, JENKINS-WEST, Tonya, HONG SHI, SUN, Lucy

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Functional Expression of Two KvLQT1-related Potassium Channels Responsible for an Inherited Idiopathic Epilepsy by Yang, Wen-Pin, Levesque, Paul C., Little, Wayne A., Conder, Mary Lee, Ramakrishnan, Pankajavalli, Neubauer, Michael G., Blanar, Michael A.

“…Benign familial neonatal convulsions (BFNC), a class of idiopathic generalized epilepsy, is an autosomal dominantly inherited disorder of newborns. BFNC has…”
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KvLQT1, a Voltage-Gated Potassium Channel Responsible for Human Cardiac Arrhythmias by Yang, Wen-Pin, Levesque, Paul C., Little, Wayne A., Conder, Mary Lee, Shalaby, Fouad Y., Blanar, Michael A.

“…The clinical features of long QT syndrome result from episodic life-threatening cardiac arrhythmias, specifically the polymorphic ventricular tachycardia…”
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Design and Synthesis of 4-Substituted Benzamides as Potent, Selective, and Orally Bioavailable IKs Blockers by LLOYD, John, SCHMIDT, Joan B., ROVNYAK, George, AHMAD, Saleem, ATWAL, Karnail S., BISAHA, Sharon N., DOWEYKO, Lidia M., STEIN, Philip D., TRAEGER, Sarah C., MATHUR, Arvind, CONDER, Mary Lee, DIMARCO, John, HARPER, Timothy W., JENKINS-WEST, Tonya, LEVESQUE, Paul C., NORMANDIN, Diane E., RUSSELL, Anita D., SERAFINO, Randolph P., SMITH, Mark A., LODGE, Nicholas J.

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Selective IKur Inhibitors for the Potential Treatment of Atrial Fibrillation: Optimization of the Phenyl Quinazoline Series Leading to Clinical Candidate 5-[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide by Gunaga, Prashantha, Lloyd, John, Mummadi, Somanadham, Banerjee, Abhisek, Dhondi, Naveen Kumar, Hennan, James, Subray, Veena, Jayaram, Ramya, Rajugowda, Nagendra, Umamaheshwar Reddy, Kommuri, Kumaraguru, Duraimurugan, Mandal, Umasankar, Beldona, Dasthagiri, Adisechen, Ashok Kumar, Yadav, Navnath, Warrier, Jayakumar, Johnson, James A, Sale, Harinath, Putlur, Siva Prasad, Saxena, Ajay, Chimalakonda, Anjaneya, Mandlekar, Sandhya, Conder, MaryLee, Xing, Dezhi, Gupta, Arun Kumar, Gupta, Anuradha, Rampulla, Richard, Mathur, Arvind, Levesque, Paul, Wexler, Ruth R, Finlay, Heather J

“…We have recently disclosed 5-phenyl-N-(pyridin-2-ylmethyl)-2-(pyrimidin-5-yl)quinazolin-4-amine 1 as a potent IKur current blocker with selectivity versus…”
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Pseudosaccharin amines as potent and selective KV1.5 blockers by Lloyd, John, Finlay, Heather J., Kover, Alexander, Johnson, James, Pi, Zulan, Jiang, Ji, Neels, James, Cavallaro, Cullen, Wexler, Ruth, Conder, Mary Lee, Shi, Hong, Li, Danshi, Sun, Huabin, Chimalakonda, Anjaneya, Huang, Christine, Salvati, Mark, Levesque, Paul

“…Synthesis of pseudosaccharin amines as KV1.5 blockers led to the discovery of potent antagonists such as 17d. These compounds had potent pharmacodynamic…”
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Discovery of 5-Phenyl-N-(pyridin-2-ylmethyl)-2-(pyrimidin-5-yl)quinazolin-4-amine as a Potent IKur Inhibitor by Finlay, Heather J., Johnson, James A., Lloyd, John L., Jiang, Ji, Neels, James, Gunaga, Prashantha, Banerjee, Abhisek, Dhondi, Naveen, Chimalakonda, Anjaneya, Mandlekar, Sandhya, Conder, Mary Lee, Sale, Harinath, Xing, Dezhi, Levesque, Paul, Wexler, Ruth R.

“…A new series of phenylquinazoline inhibitors of K v 1.5 is disclosed. The series was optimized for K v 1.5 potency, selectivity versus h ERG, pharmacokinetic…”
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Discovery of (( S )-5-(Methoxymethyl)-7-(1-methyl-1 H -indol-2-yl)-2-(trifluoromethyl)-4,7-dihydropyrazolo[1,5- a ]pyrimidin-6-yl)(( S )-2-(3-methylisoxazol-5-yl)pyrrolidin-1-yl)methanone As a Potent and Selective I Kur Inhibitor by Finlay, Heather J., Lloyd, John, Vaccaro, Wayne, Kover, Alexander, Yan, Lin, Bhave, Gauri, Prol, Joseph, Huynh, Tram, Bhandaru, Rao, Caringal, Yolanda, DiMarco, John, Gan, Jinping, Harper, Tim, Huang, Christine, Conder, Mary Lee, Sun, Huabin, Levesque, Paul, Blanar, Michael, Atwal, Karnail, Wexler, Ruth

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Pseudosaccharin amines as potent and selective K V 1.5 blockers by Lloyd, John, Finlay, Heather J., Kover, Alexander, Johnson, James, Pi, Zulan, Jiang, Ji, Neels, James, Cavallaro, Cullen, Wexler, Ruth, Conder, Mary Lee, Shi, Hong, Li, Danshi, Sun, Huabin, Chimalakonda, Anjaneya, Huang, Christine, Salvati, Mark, Levesque, Paul

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Dihydropyrazolopyrimidines containing benzimidazoles as Kv1.5 potassium channel antagonists by LLOYD, John, FINLAY, Heather J, CONDER, Marylee, JENKINS-WEST, Tonya, HUABIN SUN, DANSHI LI, LEVESQUE, Paul, ATWAL, Karnail, KOVER, Alexander, PROL, Joseph, LIN YAN, BHANDARU, Rao, VACCARO, Wayne, HUYNH, Tram, HUANG, Christine S

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Discovery of 5‑Phenyl‑N‑(pyridin-2-ylmethyl)-2-(pyrimidin-5-yl)quinazolin-4-amine as a Potent I Kur Inhibitor by Finlay, Heather J, Johnson, James A, Lloyd, John L, Jiang, Ji, Neels, James, Gunaga, Prashantha, Banerjee, Abhisek, Dhondi, Naveen, Chimalakonda, Anjaneya, Mandlekar, Sandhya, Conder, Mary Lee, Sale, Harinath, Xing, Dezhi, Levesque, Paul, Wexler, Ruth R

“…A new series of phenylquinazoline inhibitors of Kv 1.5 is disclosed. The series was optimized for Kv 1.5 potency, selectivity versus hERG, pharmacokinetic…”
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Triazolo and imidazo dihydropyrazolopyrimidine potassium channel antagonists by Finlay, Heather J., Jiang, Ji, Caringal, Yolanda, Kover, Alexander, Conder, Mary Lee, Xing, Dezhi, Levesque, Paul, Harper, Timothy, Hsueh, Mei Mann, Atwal, Karnail, Blanar, Michael, Wexler, Ruth, Lloyd, John

“…Previously disclosed C6 amido and benzimidazole dihydropyrazolopyrimidines were potent and selective blockers of IKur current. Syntheses and SAR for C6…”
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Dihydropyrazolopyrimidine inhibitors of K(V)1.5 (I(Kur)) by Vaccaro, Wayne, Huynh, Tram, Lloyd, John, Atwal, Karnail, Finlay, Heather J, Levesque, Paul, Conder, Mary Lee, Jenkins-West, Tonya, Shi, Hong, Sun, Lucy

“…A series of dihydropyrazolopyrimidine inhibitors of K(V)1.5 (I(Kur)) have been identified. The synthesis, structure-activity relationships and selectivity…”
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Correction to Discovery of (( S )-5-(Methoxymethyl)-7-(1-methyl-1 H -indol-2-yl)-2-(trifluoromethyl)-4,7-dihydropyrazolo[1,5- a ]pyrimidin-6-yl)(( S )-2-(3-methylisoxazol-5-yl)pyrrolidin-1-yl)methanone As a Potent and Selective I Kur Inhibitor by Finlay, Heather J., Lloyd, John, Vaccaro, Wayne, Kover, Alexander, Yan, Lin, Bhave, Gauri, Prol, Joseph, Huynh, Tram, Bhandaru, Rao, Caringal, Yolanda, DiMarco, John, Gan, Jinping, Harper, Tim, Huang, Christine, Conder, Mary Lee, Sun, Huabin, Levesque, Paul, Blanar, Michael, Atwal, Karnail, Wexler, Ruth

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Pyrano-[2,3 b]-pyridines as potassium channel antagonists by Finlay, Heather J., Lloyd, John, Nyman, Michael, Conder, Mary Lee, West, Tonya, Levesque, Paul, Atwal, Karnail

“…The design and synthesis of a series of highly functionalized pyrano-[2,3 b]-pyridines is described. These compounds were assayed for their ability to block…”
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Benzopyran sulfonamides as Kv1.5 potassium channel blockers by LLOYD, John, ATWAL, Karnail S, JENKINS-WEST, Tonya, LEVESQUE, Paul, FINLAY, Heather J, NYMAN, Michael, HUYNH, Tram, BHANDARU, Rao, KOVER, Alexander, SCHMIDT, Joan, VACCARO, Wayne, CONDER, Mary Lee

“…K(V)1.5 blockers have the potential to be atrium-selective agents for treatment of atrial fibrillation. The benzopyrans provide a template for the synthesis of…”
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Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective K V1.5 blockers by Lloyd, John, Finlay, Heather J., Vacarro, Wayne, Hyunh, Tram, Kover, Alexander, Bhandaru, Rao, Yan, Lin, Atwal, Karnail, Conder, Mary Lee, Jenkins-West, Tonya, Shi, Hong, Huang, Christine, Li, Danshi, Sun, Huabin, Levesque, Paul

“…Design and synthesis of pyrazolodihydropyrimidines as K V1.5 blockers led to the discovery of 7d as a potent and selective antagonist. This compound showed…”
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Dihydropyrazolopyrimidine Inhibitors of K sub(V)1.5 (I sub(Kur)) by Vaccaro, Wayne, Huynh, Tram, Lloyd, John, Atwal, Karnail, Finlay, Heather J, Levesque, Paul, Conder, Mary Lee, Jenkins-West, Tonya, Shi, Hong, Sun, Lucy

“…A series of dihydropyrazolopyrimidine inhibitors of K sub(V)1.5 (I sub(Kur)) have been identified. The synthesis, structure-activity relationships and…”
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