Search Results - "Condeelis, J."

Macrophage contact induces RhoA GTPase signaling to trigger tumor cell intravasation by Roh-Johnson, M, Bravo-Cordero, J J, Patsialou, A, Sharma, V P, Guo, P, Liu, H, Hodgson, L, Condeelis, J

“…Most cancer patients die as a result of metastasis, thus it is important to understand the molecular mechanisms of dissemination, including intra- and…”
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Blood vessel endothelium-directed tumor cell streaming in breast tumors requires the HGF/C-Met signaling pathway by Leung, E, Xue, A, Wang, Y, Rougerie, P, Sharma, V P, Eddy, R, Cox, D, Condeelis, J

“…During metastasis to distant sites, tumor cells migrate to blood vessels. In vivo , breast tumor cells utilize a specialized mode of migration known as…”
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Arg/Abl2 promotes invasion and attenuates proliferation of breast cancer in vivo by Gil-Henn, H, Patsialou, A, Wang, Y, Warren, M S, Condeelis, J S, Koleske, A J

“…Tumor progression is a complex, multistep process involving accumulation of genetic aberrations and alterations in gene expression patterns leading to…”
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Autocrine HBEGF expression promotes breast cancer intravasation, metastasis and macrophage-independent invasion in vivo by Zhou, Z N, Sharma, V P, Beaty, B T, Roh-Johnson, M, Peterson, E A, Van Rooijen, N, Kenny, P A, Wiley, H S, Condeelis, J S, Segall, J E

“…Increased expression of HBEGF in estrogen receptor-negative breast tumors is correlated with enhanced metastasis to distant organ sites and more rapid disease…”
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Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE by Carmona, G, Perera, U, Gillett, C, Naba, A, Law, A-L, Sharma, V P, Wang, J, Wyckoff, J, Balsamo, M, Mosis, F, De Piano, M, Monypenny, J, Woodman, N, McConnell, R E, Mouneimne, G, Van Hemelrijck, M, Cao, Y, Condeelis, J, Hynes, R O, Gertler, F B, Krause, M

“…Cancer invasion is a hallmark of metastasis. The mesenchymal mode of cancer cell invasion is mediated by elongated membrane protrusions driven by the assembly…”
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Autocrine CSF1R signaling mediates switching between invasion and proliferation downstream of TGFβ in claudin-low breast tumor cells by Patsialou, A, Wang, Y, Pignatelli, J, Chen, X, Entenberg, D, Oktay, M, Condeelis, J S

“…Patient data suggest that colony-stimulating factor-1 (CSF1) and its receptor (CSF1R) have critical roles during breast cancer progression. We have previously…”
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Profilin-1 downregulation has contrasting effects on early vs late steps of breast cancer metastasis by Ding, Z, Joy, M, Bhargava, R, Gunsaulus, M, Lakshman, N, Miron-Mendoza, M, Petroll, M, Condeelis, J, Wells, A, Roy, P

“…Profilin1 (Pfn1), a ubiquitously expressed actin-binding protein, has an indispensable role in migration and proliferation of normal cells. Seemingly contrary…”
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Imaging interactions between macrophages and tumour cells that are involved in metastasis in vivo and in vitro by DOVAS, A., PATSIALOU, A., HARNEY, A.S., CONDEELIS, J., COX, D.

“…Summary Tumour‐associated macrophages participate in several protumour functions including tumour growth and angiogenesis, and facilitate almost every step of…”
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Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis by Smirnova, T, Zhou, Z N, Flinn, R J, Wyckoff, J, Boimel, P J, Pozzuto, M, Coniglio, S J, Backer, J M, Bresnick, A R, Condeelis, J S, Hynes, N E, Segall, J E

“…Many malignancies show increased expression of the epidermal growth factor (EGF) receptor family member ErbB3 (HER3). ErbB3 binds heregulin β-1 (HRGβ1) and…”
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A critical step in metastasis : In vivo analysis of intravasation at the primary tumor by WYCKOFF, J. B, JONES, J. G, CONDEELIS, J. S, SEGALL, J. E

“…Detailed evaluation of all steps in tumor cell metastasis is critical for evaluating the cell mechanisms controlling metastasis. Using green fluorescent…”
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Profilin1 regulates invadopodium maturation in human breast cancer cells by Valenzuela-Iglesias, A., Sharma, V.P., Beaty, B.T., Ding, Z., Gutierrez-Millan, L.E., Roy, P., Condeelis, J.S., Bravo-Cordero, J.J.

“…Invadopodia are actin-driven membrane protrusions that show oscillatory assembly and disassembly causing matrix degradation to support invasion and…”
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The Structure of Nonvertebrate Actin: Implications for the ATP Hydrolytic Mechanism by Vorobiev, S., Strokopytov, B., Drubin, D. G., Frieden, C., Ono, S., Condeelis, J., Rubenstein, P. A., Almo, S. C.

“…The structures of Saccharomyces cerevisiae, Dictyostelium, and Caenorhabditis elegans actin bound to gelsolin segment-1 have been solved and refined at…”
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MC13-0019 Tumor microenvironment of metastasis: An imaging based marker of risk for distant metastasis of breast cancer by Jones, J, Xue, X, Lin, H, Oktay, M, Robinson, B, Gertler, F, Glass, A, Sparano, J, Condeelis, J, Rohan, T

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The Physiological Significance of β-actin mRNA Localization in Determining Cell Polarity and Directional Motility by Shestakova, Elena A., Singer, Robert H., Condeelis, John

“…β-actin mRNA is localized near the leading edge in several cell types, where actin polymerization is actively promoting forward protrusion. The localization of…”
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Abstract BS1-1: High resolution intravital imaging of the mechanism of how breast cancer initiates and sustains systemic dissemination by Condeelis, J

“…Abstract Multiphoton microscopy of live animals (IVI) has revolutionized our understanding of cancer metastasis. IVI demonstrates that TMEM, the intravasation…”
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Mycobacterial Infection of Macrophages Results in Membrane-Permeable Phagosomes by Teitelbaum, R., Cammer, M., Maitland, M. L., Freitag, N. E., Condeelis, J., Bloom, B. R.

“…Cell-mediated immunity is critical for host resistance to tuberculosis. T lymphocytes recognizing antigens presented by the major histocompatibility complex…”
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The collection of the motile population of cells from a living tumor by WYCKOFF, Jeffrey B, SEGALL, Jeffrey E, CONDEELIS, John S

“…In this study, we report that needles containing chemoattractants can be used to collect the subpopulation of motile and chemotactic tumor cells from a primary…”
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Tumor cells caught in the act of invading: their strategy for enhanced cell motility by Wang, Weigang, Goswami, Sumanta, Sahai, Erik, Wyckoff, Jeffrey B., Segall, Jeffrey E., Condeelis, John S.

“…Invasion of neighboring extracellular matrix tissue, the lymphatic system and blood vessels is a key element of tumor cell metastasis in many epithelial…”
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Cell motility of tumor cells visualized in living intact primary tumors using green fluorescent protein by FARINA, K. L, WYCKOFF, J. B, RIVERA, J, LEE, H, SEGALL, J. E, CONDEELIS, J. S, JONES, J. G

“…Metastasis is the leading cause of death in cancer patients. Cell motility is believed to be a necessary step in the metastatic process (L. Liotta and W. G…”
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Imaging of cancer invasion and metastasis using green fluorescent protein by Condeelis, J.S., Wyckoff, J., Segall, J.E.

“…The use of green fluorescent protein to fluorescently tag tumour cells has allowed investigators to open the “black box” of metastasis in order to visualise…”
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