Search Results - "Conde, Jonas N"

Blockade of Autocrine CCL5 Responses Inhibits Zika Virus Persistence and Spread in Human Brain Microvascular Endothelial Cells by Mladinich, Megan C, Conde, Jonas N, Schutt, William R, Sohn, Sook-Young, Mackow, Erich R

“…Zika virus (ZIKV) is a neurovirulent flavivirus that uniquely causes fetal microcephaly, is sexually transmitted, and persists in patients for up to 6 months…”
Get full text

ZIKV induction of tristetraprolin in endothelial and Sertoli cells post-transcriptionally inhibits IFNβ/λ expression and promotes ZIKV persistence by Schutt, William R, Conde, Jonas N, Mladinich, Megan C, Himmler, Grace E, Mackow, Erich R

“…Our findings define a novel role for ZIKV-induced TTP expression in regulating IFNβ/IFNλ production in primary hBMECs and Sertoli cells. These cells comprise…”
Get full text

Establishment of a CPER reverse genetics system for Powassan virus defines attenuating NS1 glycosylation sites and an infectious NS1-GFP11 reporter virus by Conde, Jonas N, Himmler, Grace E, Mladinich, Megan C, Setoh, Yin Xiang, Amarilla, Alberto A, Schutt, William R, Saladino, Nicholas, Gorbunova, Elena E, Salamango, Daniel J, Benach, Jorge, Kim, Hwan Keun, Mackow, Erich R

“…Powassan virus (POWV) is an emerging tick-borne Flavivirus that causes lethal encephalitis and long-term neurologic damage. Currently, there are no POWV…”
Get full text

Mapping the interactions of dengue virus NS1 protein with human liver proteins using a yeast two-hybrid system: identification of C1q as an interacting partner by Silva, Emiliana M, Conde, Jonas N, Allonso, Diego, Nogueira, Mauricio L, Mohana-Borges, Ronaldo

“…Dengue constitutes a global health concern. The clinical manifestation of this disease varies from mild febrile illness to severe hemorrhage and/or fatal…”
Get full text

NS5 Sumoylation Directs Nuclear Responses That Permit Zika Virus To Persistently Infect Human Brain Microvascular Endothelial Cells by Conde, Jonas N, Schutt, William R, Mladinich, Megan, Sohn, Sook-Young, Hearing, Patrick, Mackow, Erich R

“…Zika virus (ZIKV) is cytopathic to neurons and persistently infects brain microvascular endothelial cells (hBMECs), which normally restrict viral access to…”
Get full text

ApoA1 Neutralizes Proinflammatory Effects of Dengue Virus NS1 Protein and Modulates Viral Immune Evasion by Coelho, Diego R, Carneiro, Pedro H, Mendes-Monteiro, Lucas, Conde, Jonas N, Andrade, Iamara, Cao, Thu, Allonso, Diego, White-Dibiasio, Michael, Kuhn, Richard J, Mohana-Borges, Ronaldo

“…Dengue is a mosquito-borne infectious disease that is highly endemic in tropical and subtropical countries. Symptomatic patients can rapidly progress to severe…”
Get full text

Age-dependent Powassan virus lethality is linked to glial cell activation and divergent neuroinflammatory cytokine responses in a murine model by Mladinich, Megan C, Himmler, Grace E, Conde, Jonas N, Gorbunova, Elena E, Schutt, William R, Sarkar, Shayan, Tsirka, Styliani-Anna E, Kim, Hwan Keun, Mackow, Erich R

“…Powassan virus (POWV) is an emergent tick-borne flavivirus that causes fatal encephalitis in the elderly and long-term neurologic sequelae in survivors. How…”
Get more information

Powassan Viruses Spread Cell to Cell during Direct Isolation from Ixodes Ticks and Persistently Infect Human Brain Endothelial Cells and Pericytes by Conde, Jonas N, Sanchez-Vicente, Santiago, Saladino, Nicholas, Gorbunova, Elena E, Schutt, William R, Mladinich, Megan C, Himmler, Grace E, Benach, Jorge, Kim, Hwan Keun, Mackow, Erich R

“…Powassan viruses (POWVs) are neurovirulent tick-borne flaviviruses emerging in the northeastern United States, with a 2% prevalence in Long Island (LI) deer…”
Get full text

Dengue Virus NS1 Protein Modulates Cellular Energy Metabolism by Increasing Glyceraldehyde-3-Phosphate Dehydrogenase Activity by Allonso, Diego, Andrade, Iamara S, Conde, Jonas N, Coelho, Diego R, Rocha, Daniele C P, da Silva, Manuela L, Ventura, Gustavo T, Silva, Emiliana M, Mohana-Borges, Ronaldo

“…Dengue is one of the main public health concerns worldwide. Recent estimates indicate that over 390 million people are infected annually with the dengue virus…”
Get full text

The Complement System in Flavivirus Infections by Conde, Jonas N, Silva, Emiliana M, Barbosa, Angela S, Mohana-Borges, Ronaldo

“…The incidence of flavivirus infections has increased dramatically in recent decades in tropical and sub-tropical climates worldwide, affecting hundreds of…”
Get full text

Dengue virus nonstructural 3 protein interacts directly with human glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and reduces its glycolytic activity by Silva, Emiliana M., Conde, Jonas N., Allonso, Diego, Ventura, Gustavo T., Coelho, Diego R., Carneiro, Pedro Henrique, Silva, Manuela L., Paes, Marciano V., Rabelo, Kíssila, Weissmuller, Gilberto, Bisch, Paulo Mascarello, Mohana-Borges, Ronaldo

“…Dengue is an important mosquito-borne disease and a global public health problem. The disease is caused by dengue virus (DENV), which is a member of the…”
Get full text

The immunodominant antibody response to Zika virus NS1 protein is characterized by cross-reactivity to self by Cavazzoni, Cecilia B, Bozza, Vicente B T, Lucas, Tostes C V, Conde, Luciana, Maia, Bruno, Mesin, Luka, Schiepers, Ariën, Ersching, Jonatan, Neris, Romulo L S, Conde, Jonas N, Coelho, Diego R, Lima, Tulio M, Alvim, Renata G F, Castilho, Leda R, de Paula Neto, Heitor A, Mohana-Borges, Ronaldo, Assunção-Miranda, Iranaia, Nobrega, Alberto, Victora, Gabriel D, Vale, Andre M

“…Besides antigen-specific responses to viral antigens, humoral immune response in virus infection can generate polyreactive and autoreactive antibodies. Dengue…”
Get full text

Mapping the Interactions of Dengue Virus NS1 Protein with Human Liver Proteins Using a Yeast Two-Hybrid System: Identification of C1q as an Interacting Partner. e57514 by Silva, Emiliana M, Conde, Jonas N, Allonso, Diego, Nogueira, Mauricio L, Mohana-Borges, Ronaldo

“…Dengue constitutes a global health concern. The clinical manifestation of this disease varies from mild febrile illness to severe hemorrhage and/or fatal…”
Get full text