Relation Between Maternal Age And Serum Concentration Of Igg Antibody To Type Iii Group B Streptococci

Coded serum samples collected from healthy obstetric patients at delivery were examined by ELISA for IgG antibody to the purified type III polysaccharide of group B streptococci. When 217 patients were divided into 4 groups according to age (group 1= 16–20 years, n = 56; group II = 21–25, n = 53; gr...

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Bibliographic Details
Published in:	The Journal of infectious diseases Vol. 170; no. 3; pp. 717 - 720
Main Authors:	Anthony, Bascom F., Concepcion, Israel Erick, Concepcion, Nelydia F., Vadheim, Constance M., Tiwari, Jawahar
Format:	Journal Article
Language:	English
Published:	United States The University of Chicago Press 01-09-1994 University of Chicago Press
Subjects:	Adolescent Adult Age groups Analysis of Variance Antibodies Antibodies, Bacterial - blood Concise Communications Disease risk Epidemiology Female Geometric mean Humans Immunoglobulin G - blood Infants Infections Labor, Obstetric Maternal Age Neonatal diseases Polysaccharides Polysaccharides, Bacterial - immunology Pregnancy - blood Pregnancy - immunology Pregnancy, High-Risk Streptococcus Streptococcus agalactiae Streptococcus agalactiae - immunology
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Summary:	Coded serum samples collected from healthy obstetric patients at delivery were examined by ELISA for IgG antibody to the purified type III polysaccharide of group B streptococci. When 217 patients were divided into 4 groups according to age (group 1= 16–20 years, n = 56; group II = 21–25, n = 53; group III = 26–30, n = 54; group IV = 31–35, n = 54), antibody concentrations were significantly lower in group I than in older patients. Fewer subjects in group I had measurable antibody levels ( ≥ 0.05 µg/mL) than in groups II-IV (41%vs. 76%, P < .001). The geometric mean in group I (0.09 ìg/mL) was significantly lower (P < .001) than in the older groups (0.23, 0.19, and 0.20 ìg/mL, respectively) with little or no overlap of the 95% confidence limits (1.96 SE) about the means. These findings may be relevant to the observation of a significantly greater risk of both early- and late-onset group B streptococcal disease in infants of teenage mothers.
Bibliography:	ark:/67375/HXZ-63C6DJWM-J Reprints or correspondence: Dr. Bascom F. Anthony, Division of Bacterial istex:CF7E1C91725EDECC5C981C89423C5D51935FF0EE ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0022-1899 1537-6613
DOI:	10.1093/infdis/170.3.717