Potential impact of nonavalent HPV vaccine in the prevention of high‐grade cervical lesions and cervical cancer in Portugal

Objective To estimate the potential impact of the nonavalent HPV vaccine for high‐grade cervical lesions and invasive cervical cancer (ICC) in Portugal. Methods The present secondary analysis used data collected in the CLEOPATRE II study on the prevalence of HPV 6/11/16/18/31/33/45/52/58 among femal...

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Published in:	International journal of gynecology and obstetrics Vol. 139; no. 1; pp. 90 - 94
Main Authors:	Pista, Angela, Oliveira, Carlos Freire, Lopes, Carlos, Cunha, Maria J., Tavares, Angelina, Dias, Macedo, Rocha, Eugénia, Conceição Telhado, Maria, Afonso, Ana, Loureiro, Mariana, Horgan, Cristina, Marques, Idalina, Cortes, Elisabete, Alegra, Sofia, Carmo Serra, Maria, Lima, Jorge, Afonso, Elisabete, Ladeira, Ana Paula, Gonçalves, Luís, Sobral, Naciolinda, Reforço, Ana Sofia, Pacheco, Maria Amália, Enriquez, José Luís, Lagoa, Antónia, Ribeiro, Vera, Ferreira, Leonor, Cadillá, António Jesús, Furtado, José Manuel, Rodrigues, Joaquim, Castro, Pedro Vieira, Almeida e Silva, António, Mota, Fernando, Moura, Paulo, Silva, Teresa Simões, Jardim, Ondina, Nascimento, Maria, Borrego, Jorge, Fernandes, Rosário, Vitorino, Adelaide, Paula, Teresa, Palma, Fátima, Maia, Paula, Fatela, Ana, Sobral, Daniela, Pereira, Paula, Grilo, Isabel, Ambrósio, Paula, Torrezão, Isabel, Biscaia, Isabel, Nunes, Sílvia, Araújo, Mariana, Sâncio, Susana, Valente, Gisela, Mendonça, Sara, Santos, Sofia
Format:	Journal Article
Language:	English
Published:	United States 01-10-2017
Subjects:	Adult Aged Aged, 80 and over Cervical cancer Cervical Intraepithelial Neoplasia - epidemiology Cervical Intraepithelial Neoplasia - prevention & control CLEOPATRE II study Female High‐grade cervical intraepithelial lesions HPV prevalence HPV vaccines Humans Middle Aged Papillomaviridae - genetics Papillomaviridae - isolation & purification Papillomavirus Infections - epidemiology Papillomavirus Infections - prevention & control Papillomavirus Vaccines - administration & dosage Portugal Prevalence Uterine Cervical Neoplasms - epidemiology Uterine Cervical Neoplasms - prevention & control Vaccination - utilization Women's Health Services Young Adult CLEOPATRE II study HPV vaccines HPV prevalence High-grade cervical intraepithelial lesions Portugal Cervical cancer
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Summary:	Objective To estimate the potential impact of the nonavalent HPV vaccine for high‐grade cervical lesions and invasive cervical cancer (ICC) in Portugal. Methods The present secondary analysis used data collected in the CLEOPATRE II study on the prevalence of HPV 6/11/16/18/31/33/45/52/58 among female patients aged 20–88 years. The prevalence of HPV types in patients with cervical intraepithelial neoplasia (CIN) grades 2/3 and ICC was examined. Results Data were included from 582 patients. There were 177, 341, and 64 patients with CIN2, CIN3, and ICC, respectively, and 169 (95.5%), 339 (99.4%), and 62 (96.9) of them had HPV infections. Of patients with HPV infections, HPV 16, 18, 31, 33, 45, 52, and 58 infections were identified in 150 (88.8%), 329 (97.1%), and 60 (96.8%) patients with CIN2, CIN3, and ICC, respectively. HPV genotypes 6, 11, 16, 18, 31, 33, 45, 52, and 58 were identified in 540 (94.7%) of the patients with HPV infections. Conclusion The addition of the five HPV genotypes included in the nonavalent HPV vaccine (HPV 31/33/45/52/58) could result in the new HPV vaccine preventing 94.7% of CIN2/3 and ICC occurrences. Secondary analysis of CLEOPATRE II Portugal study data demonstrated that the nonavalent HPV vaccine could prevent 94.7% of high‐grade cervical lesions and invasive cervical cancers.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0020-7292 1879-3479
DOI:	10.1002/ijgo.12243