Search Results - "Conboy, Irina M"

A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood by Rebo, Justin, Mehdipour, Melod, Gathwala, Ranveer, Causey, Keith, Liu, Yan, Conboy, Michael J., Conboy, Irina M.

“…Heterochronic parabiosis rejuvenates the performance of old tissue stem cells at some expense to the young, but whether this is through shared circulation or…”
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Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches by Conboy, Irina M., Rando, Thomas A.

“…Aging is unmistakable and undeniable in mammals. Interestingly, mice develop cataracts, muscle atrophy, osteoporosis, obesity, diabetes and cognitive deficits…”
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Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity by Conboy, Michael J., Conboy, Irina M., Rando, Thomas A.

“…Summary Pairing two animals in parabiosis to test for systemic or circulatory factors from one animal affecting the other animal has been used in scientific…”
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Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells by Carlson, Morgan E, Hsu, Michael, Conboy, Irina M

“…Adult skeletal muscle robustly regenerates throughout an organism's life, but as the muscle ages, its ability to repair diminishes and eventually fails…”
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Detection of unamplified target genes via CRISPR–Cas9 immobilized on a graphene field-effect transistor by Hajian, Reza, Balderston, Sarah, Tran, Thanhtra, deBoer, Tara, Etienne, Jessy, Sandhu, Mandeep, Wauford, Noreen A., Chung, Jing-Yi, Nokes, Jolie, Athaiya, Mitre, Paredes, Jacobo, Peytavi, Regis, Goldsmith, Brett, Murthy, Niren, Conboy, Irina M., Aran, Kiana

“…Most methods for the detection of nucleic acids require many reagents and expensive and bulky instrumentation. Here, we report the development and testing of a…”
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A temporal switch from notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis by Brack, Andrew S, Conboy, Irina M, Conboy, Michael J, Shen, Jeanne, Rando, Thomas A

“…The temporal switch from progenitor cell proliferation to differentiation is essential for effective adult tissue repair. We previously reported the critical…”
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Age‐Associated Increase in BMP Signaling Inhibits Hippocampal Neurogenesis by Yousef, Hanadie, Morgenthaler, Adam, Schlesinger, Christina, Bugaj, Lukasz, Conboy, Irina M., Schaffer, David V.

“…Hippocampal neurogenesis, the product of resident neural stem cell proliferation and differentiation, persists into adulthood but decreases with organismal…”
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Loss of stem cell regenerative capacity within aged niches by Carlson, Morgan E., Conboy, Irina M.

“…Summary This work uncovers novel mechanisms of aging within stem cell niches that are evolutionarily conserved between mice and humans and affect both…”
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K-means quantization for a web-based open-source flow cytometry analysis platform by Wong, Nathan, Kim, Daehwan, Robinson, Zachery, Huang, Connie, Conboy, Irina M.

“…Flow cytometry (FCM) is an analytic technique that is capable of detecting and recording the emission of fluorescence and light scattering of cells or…”
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Application of bio-orthogonal proteome labeling to cell transplantation and heterochronic parabiosis by Liu, Yan, Conboy, Michael J., Mehdipour, Melod, Liu, Yutong, Tran, Thanhtra P., Blotnick, Aaron, Rajan, Prasanna, Santos, Thalie Cavalcante, Conboy, Irina M.

“…Studies of heterochronic parabiosis demonstrated that with age, the composition of the circulatory milieu changes in ways that broadly inhibit tissue…”
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Non-Intrinsic, Systemic Mechanisms of Cellular Senescence by Schwartz, Rachael E, Conboy, Irina M

“…Cellular senescence is believed to contribute to aging and disease through the activity of secreted factors that promote inflammation, remodel the…”
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The Microfluidic Toolbox for Analyzing Exosome Biomarkers of Aging by DeCastro, Jonalyn, Littig, Joshua, Chou, Peichi Peggy, Mack-Onyeike, Jada, Srinivasan, Amrita, Conboy, Michael J, Conboy, Irina M, Aran, Kiana

“…As the fields of aging and neurological disease expand to liquid biopsies, there is a need to identify informative biomarkers for the diagnosis of…”
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Relative roles of TGF‐β1 and Wnt in the systemic regulation and aging of satellite cell responses by Carlson, Morgan E., Conboy, Michael J., Hsu, Michael, Barchas, Laurel, Jeong, Jaemin, Agrawal, Anshu, Mikels, Amanda J., Agrawal, Smita, Schaffer, David V., Conboy, Irina M.

“…Summary Muscle stem (satellite) cells are relatively resistant to cell‐autonomous aging. Instead, their endogenous signaling profile and regenerative capacity…”
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Notch-Mediated Restoration of Regenerative Potential to Aged Muscle by Conboy, Irina M., Conboy, Michael J., Smythe, Gayle M., Rando, Thomas A.

“…A hallmark of aging is diminished regenerative potential of tissues, but the mechanism of this decline is unknown. Analysis of injured muscle revealed that,…”
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Skeletal muscle as an experimental model of choice to study tissue aging and rejuvenation by Etienne, Jessy, Liu, Chao, Skinner, Colin M, Conboy, Michael J, Conboy, Irina M

“…Skeletal muscle is among the most age-sensitive tissues in mammal organisms. Significant changes in its resident stem cells (i.e., satellite cells, SCs),…”
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Pharmacological inhibition of myostatin/TGF-β receptor/pSmad3 signaling rescues muscle regenerative responses in mouse model of type 1 diabetes by Jeong, Jaemin, Conboy, Michael J, Conboy, Irina M

“…Aim： To study the influence of acute experimental diabetes on the regenerative potential of muscle stem （satellite） cells in mice. Methods： Male C57BL/6 young…”
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The Regulation of Notch Signaling Controls Satellite Cell Activation and Cell Fate Determination in Postnatal Myogenesis by Conboy, Irina M., Rando, Thomas A.

“…We have studied the role of Notch-1 and its antagonist Numb in the activation of satellite cells during postnatal myogenesis. Activation of Notch-1 promoted…”
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Aging, Stem Cells and Tissue Regeneration: Lessons from Muscle by Conboy, Irina M., Rando, Thomas A.

“…With age, there is a gradual decline in the regenerative properties of most tissues due to a combination of age-dependent changes in tissue-specific stem cells…”
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Author Correction: Application of bio-orthogonal proteome labeling to cell transplantation and heterochronic parabiosis by Liu, Yan, Conboy, Michael J., Mehdipour, Melod, Liu, Yutong, Tran, Thanhtra P., Blotnick, Aaron, Rajan, Prasanna, Santos, Thalie Cavalcante, Conboy, Irina M.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Autologous treatment for ALS with implication for broad neuroprotection by Kim, Daehwan, Kim, Subin, Sung, Ashley, Patel, Neetika, Wong, Nathan, Conboy, Michael J, Conboy, Irina M

“…Amyotrophic lateral sclerosis (ALS) is characterized by a progressive loss of motor neurons (MNs), leading to paralysis, respiratory failure and death within…”
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