Search Results - "Comstock, Thomas J."

Evaluation of an in vitro dialysis system to predict drug removal by Hudson, Joanna Q., Comstock, Thomas J., Feldman, George M.

“…Background. Variation in the extent of drug removal under different dialysis conditions presents a challenge for prediction of drug elimination and dosage…”
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Nephrology pharmaceutical care preceptorship: a programmatic and clinical outcomes assessment. 2000 by Matzke, Gary R, St Peter, Wendy L, Comstock, Thomas J, Foote, Edward F

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The Pharmacokinetics of Subcutaneous Enoxaparin in End-Stage Renal Disease by Brophy, Donald F., Wazny, Lori D., Gehr, Todd W. B., Comstock, Thomas J., Venitz, Jürgen

“…Study Objective. To evaluate the pharmacokinetics of enoxaparin in end‐stage renal disease (ESRD), and determine if dosage reduction is necessary to maintain…”
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Nephrology pharmaceutical care preceptorship : A programmatic and clinical outcomes assessment by MATZKE, Gary R, ST PETER, Wendy L, COMSTOCK, Thomas J, FOOTE, Edward F

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Considerations for optimal iron use for anemia due to chronic kidney disease by Hudson, Joanna Q., Comstock, Thomas J.

“…Background: Availability of recombinant human erythropoietin (rHuEPO) has improved the treatment of anemia due to chronic kidney disease (CKD). Iron deficiency…”
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Pharmacokinetics of gabapentin in subjects with various degrees of renal function by Blum, R A, Comstock, T J, Sica, D A, Schultz, R W, Keller, E, Reetze, P, Bockbrader, H, Tuerck, D, Busch, J A, Reece, P A

“…The pharmacokinetics of oral gabapentin (400 mg) was studied in normal subjects and in subjects with various degrees of renal function. Sixty subjects…”
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Nephrology Pharmaceutical Care Preceptorship: A Programmatic and Clinical Outcomes Assessment by Matzke, Gary R, Peter, Wendy L St, Comstock, Thomas J, Foote, Edward F

“…OBJECTIVE: The University of Pittsburgh Nephrology Pharmaceutical Care Preceptorship (NPCP) program was conceived to acquaint health system pharmacists with…”
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Effect of two administration schedules of an enteral nutrient formula on phenytoin bioavailability by Krueger, K A, Garnett, W R, Comstock, T J, Fitzsimmons, W E, Karnes, H T, Pellock, J M

“…Continuous nasogastric (NG) administration of enteral nutrient formulas (ENFs) reportedly lowers phenytoin (PHT) concentrations. We studied the effects of two…”
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Nephrology: Nephrology Pharmaceutical Care Preceptorship: A Programmatic and Clinical Outcomes Assessment by Matzke, Gary R, Peter, Wendy L St, Comstock, Thomas J, Foote, Edward F

“…Objective: The University of Pittsburgh Nephrology Pharmaceutical Care Preceptorship (NPCP) program was conceived to acquaint health system pharmacists with…”
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Lidocaine anesthesia: comparison of iontophoresis, injection, and swabbing by Russo, Jr, J, Lipman, A G, Comstock, T J, Page, B C, Stephen, R L

“…The duration and depth of anesthesia produced by lidocaine with three methods of administration were studied. To test duration of anesthesia, either lidocaine…”
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A dose-response trial of once-daily diltiazem by Felicetta, J V, Serfer, H M, Cutler, N R, Comstock, T J, Huber, G L, Weir, M R, Hafner, K, Park, G D

“…This trial was performed to determine the safe and effective dosage range of once daily diltiazem (diltiazem CD) capsules for treatment of essential…”
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Temperature dependence of phenytoin-protein binding in serum: effects of uremia and hypoalbuminemia by Allison, T B, Comstock, T J

“…Phenytoin-protein binding was determined as a function of temperature in uremic patients with normal albumin and in uremic patients with hypoalbuminemia. Free…”
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A comparative bioavailability study of carbamazepine tablets and a chewable tablet formulation by Maas, B, Garnett, W R, Pellock, J M, Comstock, T J

“…Differences in product formulations have been shown to affect the therapeutic response by altering the relative bioavailability and pharmacokinetics of a drug…”
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Ranitidine bioavailability and disposition kinetics in patients undergoing chronic hemodialysis by Comstock, T J, Sica, D A, Harford, A, Eshelman, F

“…The absorption and disposition of single-dose intravenous (i.v.) and oral ranitidine were evaluated in 6 patients undergoing chronic hemodialysis. Ranitidine…”
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Ranitidine accumulation in patients undergoing chronic hemodialysis by Comstock, T J, Sica, D A, Stone, S, Davis, J, Garnett, W R, Karnes, H T, Warner, C W

“…Ranitidine accumulation was assessed in 20 patients undergoing chronic hemodialysis following oral daily doses of 150 mg ranitidine for 10 days. Serum…”
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Single dose comparison of the relative bioavailability of phenytoin suspension and extended capsules by Fitzsimmons, W E, Garnett, W R, Comstock, T J, Pellock, J M

“…There is presently only one preparation of phenytoin approved for once-daily dosing--extended phenytoin sodium capsules. We have observed many hospitalized…”
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Binding of quinidine to plasma proteins in normal subjects and in patients with hyperlipoproteinemias by Kates, R E, Sokoloski, T D, Comstock, T J

“…Quinidine in the plasma binds to various lipoproteins as well as to albumin. With the use of computer simulations the effect of varying the serum level of each…”
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Rapid high-pressure liquid chromatographic determination of quinidine and dihydroquinidine in plasma samples by Kates, R E, McKennon, D W, Comstock, T J

“…A high-pressure liquid chromatographic assay for quinidine and dihydroquinidine was developed. A cation-exchange column was utilized with an eluting solvent pH…”
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