Search Results - "Compton, Duane A."

Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation by Kabeche, Lilian, Compton, Duane A.

“…Cyclin A is shown to maintain unstable kinetochore–microtubule (k–MT) attachments in prometaphase in order to allow for error correction; at the…”
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Proliferation of aneuploid human cells is limited by a p53-dependent mechanism by Thompson, Sarah L, Compton, Duane A

“…Most solid tumors are aneuploid, and it has been proposed that aneuploidy is the consequence of an elevated rate of chromosome missegregation in a process…”
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Checkpoint-Independent Stabilization of Kinetochore-Microtubule Attachments by Mad2 in Human Cells by Kabeche, Lilian, Compton, Duane A.

“…Faithful chromosome segregation is required for cell and organism viability and relies on both the mitotic checkpoint and the machinery that corrects…”
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Chromosome missegregation in human cells arises through specific types of kinetochore–microtubule attachment errors by Thompson, Sarah L, Compton, Duane A

“…Most solid tumors are aneuploid, and many missegregate chromosomes at high rates in a phenomenon called chromosomal instability (CIN). CIN reflects the erosion…”
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Regulation of kinetochore–microtubule attachments through homeostatic control during mitosis by Godek, Kristina M., Kabeche, Lilian, Compton, Duane A.

“…Faithful chromosome segregation during mitosis depends on the bi-oriented attachment of chromosomes to spindle microtubules through their kinetochores. The…”
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Examining the link between chromosomal instability and aneuploidy in human cells by Thompson, Sarah L, Compton, Duane A

“…Solid tumors can be highly aneuploid and many display high rates of chromosome missegregation in a phenomenon called chromosomal instability (CIN). In…”
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Deviant Kinetochore Microtubule Dynamics Underlie Chromosomal Instability by Bakhoum, Samuel F., Genovese, Giulio, Compton, Duane A.

“…The persistent malattachment of microtubules to chromosomes at kinetochores is a major mechanism of chromosomal instability (CIN) [1, 2]. In normal diploid…”
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DNA-damage response during mitosis induces whole-chromosome missegregation by Bakhoum, Samuel F, Kabeche, Lilian, Murnane, John P, Zaki, Bassem I, Compton, Duane A

“…Many cancers display both structural (s-CIN) and numerical (w-CIN) chromosomal instabilities. Defective chromosome segregation during mitosis has been shown to…”
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Adaptive Resistance to an Inhibitor of Chromosomal Instability in Human Cancer Cells by Orr, Bernardo, Talje, Lama, Liu, Zhexian, Kwok, Benjamin H., Compton, Duane A.

“…Karyotype diversity is a hallmark of solid tumors that contributes to intratumor heterogeneity. This diversity is generated by persistent chromosome…”
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The mitotic origin of chromosomal instability by Bakhoum, Samuel F., Silkworth, William T., Nardi, Isaac K., Nicholson, Joshua M., Compton, Duane A., Cimini, Daniela

“…Chromosomal instability (CIN) is a common feature of most human neoplasms and was defined, in a seminal study by Vogelstein and colleagues [1], as persistently…”
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Intact Cohesion, Anaphase, and Chromosome Segregation in Human Cells Harboring Tumor-Derived Mutations in STAG2 by Kim, Jung-Sik, He, Xiaoyuan, Orr, Bernardo, Wutz, Gordana, Hill, Victoria, Peters, Jan-Michael, Compton, Duane A, Waldman, Todd

“…Somatic mutations of the cohesin complex subunit STAG2 are present in diverse tumor types. We and others have shown that STAG2 inactivation can lead to loss of…”
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Kinetochores and disease: keeping microtubule dynamics in check by Bakhoum, Samuel F, Compton, Duane A

“…The essential role of microtubules in cell division has long been known. Yet the mechanism by which microtubule attachment to chromosomes at kinetochores is…”
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Chromosomal instability suppresses the growth of K-Ras-induced lung adenomas by Laucius, Christopher D., Orr, Bernardo, Compton, Duane A.

“…Chromosomal instability (CIN) is defined as a high rate of whole chromosome loss or gain and is a hallmark of many aneuploid solid tumors. CIN positively…”
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STAG2 promotes error correction in mitosis by regulating kinetochore-microtubule attachments by Kleyman, Marianna, Kabeche, Lilian, Compton, Duane A

“…Mutations in the STAG2 gene are present in ∼20% of tumors from different tissues of origin. STAG2 encodes a subunit of the cohesin complex, and tumors with…”
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Shugoshin-1 balances Aurora B kinase activity via PP2A to promote chromosome bi-orientation by Meppelink, Amanda, Kabeche, Lilian, Vromans, Martijn J M, Compton, Duane A, Lens, Susanne M A

“…Correction of faulty kinetochore-microtubule attachments is essential for faithful chromosome segregation and dictated by the opposing activities of Aurora B…”
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Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability by Dumitru, Ana Maria G, Rusin, Scott F, Clark, Amber E M, Kettenbach, Arminja N, Compton, Duane A

“…The fidelity of chromosome segregation in mitosis is safeguarded by the precise regulation of kinetochore microtubule (k-MT) attachment stability. Previously,…”
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Numerical chromosomal instability mediates susceptibility to radiation treatment by Bakhoum, Samuel F., Kabeche, Lilian, Wood, Matthew D., Laucius, Christopher D., Qu, Dian, Laughney, Ashley M., Reynolds, Gloria E., Louie, Raymond J., Phillips, Joanna, Chan, Denise A., Zaki, Bassem I., Murnane, John P., Petritsch, Claudia, Compton, Duane A.

“…The exquisite sensitivity of mitotic cancer cells to ionizing radiation (IR) underlies an important rationale for the widely used fractionated radiation…”
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The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells by Manning, Amity L, Ganem, Neil J, Bakhoum, Samuel F, Wagenbach, Michael, Wordeman, Linda, Compton, Duane A

“…The human genome has three unique genes coding for kinesin-13 proteins called Kif2a, Kif2b, and MCAK (Kif2c). Kif2a and MCAK have documented roles in mitosis,…”
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Dinaciclib Induces Anaphase Catastrophe in Lung Cancer Cells via Inhibition of Cyclin-Dependent Kinases 1 and 2 by Danilov, Alexey V, Hu, Shanhu, Orr, Bernardo, Godek, Kristina, Mustachio, Lisa Maria, Sekula, David, Liu, Xi, Kawakami, Masanori, Johnson, Faye M, Compton, Duane A, Freemantle, Sarah J, Dmitrovsky, Ethan

“…Despite advances in targeted therapy, lung cancer remains the most common cause of cancer-related mortality in the United States. Chromosomal instability is a…”
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Single-cell RNA sequencing reveals the impact of chromosomal instability on glioblastoma cancer stem cells by Zhao, Yanding, Carter, Robert, Natarajan, Sivaraman, Varn, Frederick S, Compton, Duane A, Gawad, Charles, Cheng, Chao, Godek, Kristina M

“…Intra-tumor heterogeneity stems from genetic, epigenetic, functional, and environmental differences among tumor cells. A major source of genetic heterogeneity…”
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