Search Results - "Comper, Wayne D."

New insights into proteinuria/albuminuria by Comper, Wayne D., Vuchkova, Julijana, McCarthy, Kevin J.

“…The fractional clearance of proteins as measured in healthy human subjects increases 10,000–100,000- fold when studied in nephrotic patients. This remarkable…”
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Commentary: The Glomerular Endothelium Restricts Albumin Filtration by Comper, Wayne D

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Impaired Tubular Uptake Explains Albuminuria in Early Diabetic Nephropathy by RUSSO, Leileata M, SANDOVAL, Ruben M, CAMPOS, Silvia B, MOLITORIS, Bruce A, COMPER, Wayne D, BROWN, Dennis

“…Understanding the pathogenesis of albuminuria in diabetic nephropathy is important to improve methods for early diagnosis and treatment. In this study, we…”
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Disease-dependent mechanisms of albuminuria by Comper, Wayne D, Hilliard, Lucinda M, Nikolic-Paterson, David J, Russo, Leileata M

“…The mechanism of albuminuria is perhaps one of the most complex yet important questions in renal physiology today. Recent studies have directly demonstrated…”
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Inhibition of the metabolic degradation of filtered albumin is a major determinant of albuminuria by Vuchkova, Julijana, Comper, Wayne D

“…Inhibition of the degradation of filtered albumin has been proposed as a widespread, benign form of albuminuria. There have however been recent reports that…”
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Renal handling of albumin: A critical review of basic concepts and perspective by Russo, Leileata M., Bakris, George L., Comper, Wayne D.

“…Biochemical and physiological processes that underlie the mechanism of albuminuria are completely reassessed in this article in view of recent discoveries that…”
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Characterization of Immunochemically Nonreactive Urinary Albumin by Osicka, Tanya M, Comper, Wayne D

“…Conventional immunoassays underestimate the urinary albumin concentration because intact albumin in urine exists in two forms, immunoreactive and…”
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Earlier detection of microalbuminuria in diabetic patients using a new urinary albumin assay by Comper, Wayne D., Osicka, Tanya M., Clark, Malcom, MacIsaac, Richard J., Jerums, George

“…Earlier detection of microalbuminuria in diabetic patients using a new urinary albumin assay. Microalbuminuria is regarded as the most important predictor of…”
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Glomerular permeability changes of albumin in isolated glomeruli do not mimic changes in albumin excretion in vivo in diseased states by Comper, Wayne D

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Megalin/cubilin has a minor role in the proximal tubular cell uptake of filtered albumin by Comper, Wayne D

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Urine Exosomes for Non-Invasive Assessment of Gene Expression and Mutations of Prostate Cancer by Motamedinia, Piruz, Scott, Anna N, Bate, Kendall L, Sadeghi, Neda, Salazar, Guillermo, Shapiro, Edan, Ahn, Jennifer, Lipsky, Michael, Lin, James, Hruby, Greg W, Badani, Ketan K, Petrylak, Daniel P, Benson, Mitchell C, Donovan, Michael J, Comper, Wayne D, McKiernan, James M, Russo, Leileata M

“…The analysis of exosome/microvesicle (extracellular vesicles (EVs)) and the RNA packaged within them (exoRNA) has the potential to provide a non-invasive…”
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High prevalence of immuno-unreactive intact albumin in urine of diabetic patients by Comper, Wayne D., Osicka, Tanya M., Jerums, George

“…Background: Intact albumin in urine may exist in two forms, immunoreactive and immuno-unreactive. Previous estimates of albuminuria in diabetic urine have only…”
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Differences in urinary albumin detected by four immunoassays and high-performance liquid chromatography by Comper, Wayne D, Jerums, George, Osicka, Tanya M

“…Objectives: To compare the analysis of urinary albumin from diabetic patients by four conventional immunoassays including radioimmunoassay (RIA),…”
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Is there equivalency of intact albuminuria and albumin peptideuria in nephrotic states? by Comper, Wayne D

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Albuminuria is controlled primarily by proximal tubules by Comper, Wayne D.

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Mechanism of hypoalbuminemia in rodents by Koltun, Maria, Nikolovski, Julijana, Strong, Kimberley, Nikolic-Paterson, David, Comper, Wayne D

“…Normal albumin loss from the plasma is thought to be minimized by a number of mechanisms, including charge repulsion with the capillary wall and an…”
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Anomalous fractional clearance of negatively charged Ficoll relative to uncharged Ficoll by Guimarães, Marco A M, Nikolovski, Julijana, Pratt, Lynette M, Greive, Kerryn, Comper, Wayne D

“…Recent studies, using low-temperature perfusion of rat kidneys, have claimed the existence of renal charge selectivity simply on the basis of the differential…”
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The limited role of the glomerular endothelial cell glycocalyx as a barrier to transglomerular albumin transport by Comper, Wayne D

“…For over 50 years, the glomerular filter has been thought to exert an uniquely significant barrier to the transport of albumin. The glomerular endothelial cell…”
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Resolved : Normal Glomeruli Filter Nephrotic Levels of Albumin by COMPER, Wayne D, HARALDSSON, Börje, DEEN, William M

“…The glomerular filtration barrier has long been thought largely impermeable to albumin. Startling new data suggest it may not be especially important in this…”
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Identification of a Novel Natriuretic Protein in Patients With Cerebral-Renal Salt Wasting—Implications for Enhanced Diagnosis by Maesaka, John K., Imbriano, Louis J., Pinkhasov, Aaron, Muralidharan, Rajanandini, Song, Xiaomin, Russo, Leileata M., Comper, Wayne D.

“…The most vexing problem in hyponatremic conditions is to differentiate the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) from…”
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