Search Results - "Communications biology"

DeepEMhancer: a deep learning solution for cryo-EM volume post-processing by Sanchez-Garcia, Ruben, Gomez-Blanco, Josue, Cuervo, Ana, Carazo, Jose Maria, Sorzano, Carlos Oscar S., Vargas, Javier

“…Cryo-EM maps are valuable sources of information for protein structure modeling. However, due to the loss of contrast at high frequencies, they generally need…”
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SPHIRE-crYOLO is a fast and accurate fully automated particle picker for cryo-EM by Wagner, Thorsten, Merino, Felipe, Stabrin, Markus, Moriya, Toshio, Antoni, Claudia, Apelbaum, Amir, Hagel, Philine, Sitsel, Oleg, Raisch, Tobias, Prumbaum, Daniel, Quentin, Dennis, Roderer, Daniel, Tacke, Sebastian, Siebolds, Birte, Schubert, Evelyn, Shaikh, Tanvir R., Lill, Pascal, Gatsogiannis, Christos, Raunser, Stefan

“…Selecting particles from digital micrographs is an essential step in single-particle electron cryomicroscopy (cryo-EM). As manual selection of complete…”
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A comprehensive review on plasmonic-based biosensors used in viral diagnostics by Shrivastav, Anand M., Cvelbar, Uroš, Abdulhalim, Ibrahim

“…The proliferation and transmission of viruses has become a threat to worldwide biosecurity, as exemplified by the current COVID-19 pandemic. Early diagnosis of…”
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Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming by Solé-Boldo, Llorenç, Raddatz, Günter, Schütz, Sabrina, Mallm, Jan-Philipp, Rippe, Karsten, Lonsdorf, Anke S., Rodríguez-Paredes, Manuel, Lyko, Frank

“…Fibroblasts are an essential cell population for human skin architecture and function. While fibroblast heterogeneity is well established, this phenomenon has…”
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BrainSpace: a toolbox for the analysis of macroscale gradients in neuroimaging and connectomics datasets by Vos de Wael, Reinder, Benkarim, Oualid, Paquola, Casey, Lariviere, Sara, Royer, Jessica, Tavakol, Shahin, Xu, Ting, Hong, Seok-Jun, Langs, Georg, Valk, Sofie, Misic, Bratislav, Milham, Michael, Margulies, Daniel, Smallwood, Jonathan, Bernhardt, Boris C.

“…Understanding how cognitive functions emerge from brain structure depends on quantifying how discrete regions are integrated within the broader cortical…”
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Role of sleep deprivation in immune-related disease risk and outcomes by Garbarino, Sergio, Lanteri, Paola, Bragazzi, Nicola Luigi, Magnavita, Nicola, Scoditti, Egeria

“…Modern societies are experiencing an increasing trend of reduced sleep duration, with nocturnal sleeping time below the recommended ranges for health…”
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Single-cell and spatial transcriptomics enables probabilistic inference of cell type topography by Andersson, Alma, Bergenstråhle, Joseph, Asp, Michaela, Bergenstråhle, Ludvig, Jurek, Aleksandra, Fernández Navarro, José, Lundeberg, Joakim

“…The field of spatial transcriptomics is rapidly expanding, and with it the repertoire of available technologies. However, several of the transcriptome-wide…”
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Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration by Carrasco, Manuel J., Alishetty, Suman, Alameh, Mohamad-Gabriel, Said, Hooda, Wright, Lacey, Paige, Mikell, Soliman, Ousamah, Weissman, Drew, Cleveland, Thomas E., Grishaev, Alexander, Buschmann, Michael D.

“…Lipid Nanoparticles (LNPs) are used to deliver siRNA and COVID-19 mRNA vaccines. The main factor known to determine their delivery efficiency is the pKa of the…”
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Towards organoid culture without Matrigel by Kozlowski, Mark T., Crook, Christiana J., Ku, Hsun Teresa

“…Organoids—cellular aggregates derived from stem or progenitor cells that recapitulate organ function in miniature—are of growing interest in developmental…”
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An improved neuroanatomical model of the default-mode network reconciles previous neuroimaging and neuropathological findings by Alves, Pedro Nascimento, Foulon, Chris, Karolis, Vyacheslav, Bzdok, Danilo, Margulies, Daniel S., Volle, Emmanuelle, Thiebaut de Schotten, Michel

“…The brain is constituted of multiple networks of functionally correlated brain areas, out of which the default-mode network (DMN) is the largest. Most existing…”
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Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents by Mody, Vicky, Ho, Joanna, Wills, Savannah, Mawri, Ahmed, Lawson, Latasha, Ebert, Maximilian C. C. J. C., Fortin, Guillaume M., Rayalam, Srujana, Taval, Shashidharamurthy

“…Emerging outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is a major threat to public health. The morbidity is increasing due…”
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SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB by Neufeldt, Christopher J., Cerikan, Berati, Cortese, Mirko, Frankish, Jamie, Lee, Ji-Young, Plociennikowska, Agnieszka, Heigwer, Florian, Prasad, Vibhu, Joecks, Sebastian, Burkart, Sandy S., Zander, David Y., Subramanian, Baskaran, Gimi, Rayomand, Padmanabhan, Seetharamaiyer, Iyer, Radhakrishnan, Gendarme, Mathieu, El Debs, Bachir, Halama, Niels, Merle, Uta, Boutros, Michael, Binder, Marco, Bartenschlager, Ralf

“…SARS-CoV-2 is a novel virus that has rapidly spread, causing a global pandemic. In the majority of infected patients, SARS-CoV-2 leads to mild disease;…”
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Second-generation lung-on-a-chip with an array of stretchable alveoli made with a biological membrane by Zamprogno, Pauline, Wüthrich, Simon, Achenbach, Sven, Thoma, Giuditta, Stucki, Janick D., Hobi, Nina, Schneider-Daum, Nicole, Lehr, Claus-Michael, Huwer, Hanno, Geiser, Thomas, Schmid, Ralph A., Guenat, Olivier T.

“…The air-blood barrier with its complex architecture and dynamic environment is difficult to mimic in vitro. Lung-on-a-chips enable mimicking the breathing…”
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A scientometric review of genome-wide association studies by Mills, Melinda C., Rahal, Charles

“…This scientometric review of genome-wide association studies (GWAS) from 2005 to 2018 (3639 studies; 3508 traits) reveals extraordinary increases in sample…”
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Identification of SARS-CoV-2 inhibitors targeting Mpro and PLpro using in-cell-protease assay by Narayanan, Anoop, Narwal, Manju, Majowicz, Sydney A., Varricchio, Carmine, Toner, Shay A., Ballatore, Carlo, Brancale, Andrea, Murakami, Katsuhiko S., Jose, Joyce

“…SARS-CoV-2 proteases Mpro and PLpro are promising targets for antiviral drug development. In this study, we present an antiviral screening strategy involving a…”
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Mapping the immune environment in clear cell renal carcinoma by single-cell genomics by Borcherding, Nicholas, Vishwakarma, Ajaykumar, Voigt, Andrew P., Bellizzi, Andrew, Kaplan, Jacob, Nepple, Kenneth, Salem, Aliasger K., Jenkins, Russell W., Zakharia, Yousef, Zhang, Weizhou

“…Clear cell renal cell carcinoma (ccRCC) is one of the most immunologically distinct tumor types due to high response rate to immunotherapies, despite low tumor…”
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Climate-change-driven growth decline of European beech forests by Martinez del Castillo, Edurne, Zang, Christian S., Buras, Allan, Hacket-Pain, Andrew, Esper, Jan, Serrano-Notivoli, Roberto, Hartl, Claudia, Weigel, Robert, Klesse, Stefan, Resco de Dios, Victor, Scharnweber, Tobias, Dorado-Liñán, Isabel, van der Maaten-Theunissen, Marieke, van der Maaten, Ernst, Jump, Alistair, Mikac, Sjepan, Banzragch, Bat-Enerel, Beck, Wolfgang, Cavin, Liam, Claessens, Hugues, Čada, Vojtěch, Čufar, Katarina, Dulamsuren, Choimaa, Gričar, Jozica, Gil-Pelegrín, Eustaquio, Janda, Pavel, Kazimirovic, Marko, Kreyling, Juergen, Latte, Nicolas, Leuschner, Christoph, Longares, Luis Alberto, Menzel, Annette, Merela, Maks, Motta, Renzo, Muffler, Lena, Nola, Paola, Petritan, Any Mary, Petritan, Ion Catalin, Prislan, Peter, Rubio-Cuadrado, Álvaro, Rydval, Miloš, Stajić, Branko, Svoboda, Miroslav, Toromani, Elvin, Trotsiuk, Volodymyr, Wilmking, Martin, Zlatanov, Tzvetan, de Luis, Martin

“…The growth of past, present, and future forests was, is and will be affected by climate variability. This multifaceted relationship has been assessed in…”
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CRISPR/Cas9 editing of endogenous banana streak virus in the B genome of Musa spp. overcomes a major challenge in banana breeding by Tripathi, Jaindra N., Ntui, Valentine O., Ron, Mily, Muiruri, Samwel K., Britt, Anne, Tripathi, Leena

“…Presence of the integrated endogenous banana streak virus (eBSV) in the B genome of plantain (AAB) is a major challenge for breeding and dissemination of…”
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Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance by Salami, Jemilat, Alabi, Shanique, Willard, Ryan R., Vitale, Nick J., Wang, Jing, Dong, Hanqing, Jin, Meizhong, McDonnell, Donald P., Crew, Andrew P., Neklesa, Taavi K., Crews, Craig M.

“…The androgen receptor is a major driver of prostate cancer and inhibition of its transcriptional activity using competitive antagonists, such as enzalutamide…”
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pH-responsive high stability polymeric nanoparticles for targeted delivery of anticancer therapeutics by Palanikumar, L., Al-Hosani, Sumaya, Kalmouni, Mona, Nguyen, Vanessa P., Ali, Liaqat, Pasricha, Renu, Barrera, Francisco N., Magzoub, Mazin

“…The practical application of nanoparticles (NPs) as chemotherapeutic drug delivery systems is often hampered by issues such as poor circulation stability and…”
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