Search Results - "Commandeur, Jan N.M"

Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets? by Ortega Ugalde, Sandra, Boot, Maikel, Commandeur, Jan N. M., Jennings, Paul, Bitter, Wilbert, Vos, J. Chris

“…This review covers the current knowledge of the cytochrome P450 enzymes (CYPs) of the human pathogen Mycobacterium tuberculosis (Mtb) and their endogenous…”
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The role of protein plasticity in computational rationalization studies on regioselectivity in testosterone hydroxylation by cytochrome P450 BM3 mutants by de Beer, Stephanie B A, van Bergen, Laura A H, Keijzer, Karlijn, Rea, Vanina, Venkataraman, Harini, Guerra, Celia Fonseca, Bickelhaupt, F Matthias, Vermeulen, Nico P E, Commandeur, Jan N M, Geerke, Daan P

“…Recently, it was found that mutations in the binding cavity of drug-metabolizing Cytochrome P450 BM3 mutants can result in major changes in regioselectivity in…”
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Effect of UGT2B72 and CYP2C84 polymorphisms on diclofenac metabolism by Lazarska, Katarzyna E., Dekker, Stefan J., Vermeulen, Nico P.E., Commandeur, Jan N.M.

“…•UGT2B7*2 shows a strongly reduced activity in diclofenac acyl glucuronidation.•CYP2C8*4 shows a 35% reduced activity in hydroxylation of diclofenac acyl…”
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Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners by Ortega Ugalde, Sandra, de Koning, Coen P., Wallraven, Kerstin, Bruyneel, Ben, Vermeulen, Nico P. E., Grossmann, Tom N., Bitter, Wilbert, Commandeur, Jan N. M., Vos, J. Chris

“…Mycobacterium tuberculosis ( Mtb ) codes for 20 cytochrome P450 enzymes (CYPs), considered potential drug-targets due to their essential roles in bacterial…”
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A Modified Arrhenius Approach to Thermodynamically Study Regioselectivity in Cytochrome P450‐Catalyzed Substrate Conversion by Luirink, Rosa A., Verkade‐Vreeker, Marlies C. A., Commandeur, Jan N. M., Geerke, Daan P.

“…The regio‐ (and stereo‐)selectivity and specific activity of cytochrome P450s are determined by the accessibility of potential sites of metabolism (SOMs) of…”
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Characterization of cytochrome P450 isoforms involved in sequential two-step bioactivation of diclofenac to reactive p-benzoquinone imines by den Braver, Michiel W., den Braver-Sewradj, Shalenie P., Vermeulen, Nico P.E., Commandeur, Jan N.M.

“…•CYP3A4 and CYP2C9 are sequentially involved in the two-step formation of diclofenac-2,5-quinone imine.•Two-step diclofenac-1′,4′-quinone imine formation…”
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Biosynthesis of a steroid metabolite by an engineered Rhodococcus erythropolis strain expressing a mutant cytochrome P450 BM3 enzyme by Venkataraman, Harini, te Poele, Evelien M, Rosłoniec, Kamila Z, Vermeulen, Nico, Commandeur, Jan N. M, van der Geize, Robert, Dijkhuizen, Lubbert

“…In the present study, the use of Rhodococcus erythropolis mutant strain RG9 expressing the cytochrome P450 BM3 mutant M02 enzyme has been evaluated for…”
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A combined computational and experimental study on selective flucloxacillin hydroxylation by cytochrome P450 BM3 variants by Luirink, Rosa A., Dekker, Stefan J., Capoferri, Luigi, Janssen, Laura F.H., Kuiper, Cynthia L., Ari, Mehmet E., Vermeulen, Nico P.E., Vos, J. Chris, Commandeur, Jan N.M., Geerke, Daan P.

“…The 5′-hydroxymethyl metabolite of the penicillin based antibiotic flucloxacillin (FLX) is considered to be involved in bile duct damage occurring in a small…”
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Engineering a self-sufficient Mycobacterium tuberculosis CYP130 by gene fusion with the reductase-domain of CYP102A1 from Bacillus megaterium by Ortega Ugalde, Sandra, Luirink, Rosa A., Geerke, Daan P., Vermeulen, Nico P.E., Bitter, Wilbert, Commandeur, Jan N.M.

“…CYP130 belongs to the subset of cytochrome P450s from Mycobacterium tuberculosis (Mtb) that have been structurally characterized. Despite several efforts for…”
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Development of a novel cytochrome p450 bioaffinity detection system coupled online to gradient reversed-phase high-performance liquid chromatography by Kool, Jeroen, van Liempd, Sebastiaan M, Ramautar, Rawi, Schenk, Tim, Meerman, John H N, Irth, Hubertus, Commandeur, Jan N M, Vermeulen, Nico P E

“…A high-resolution screening platform, coupling online affinity detection for mammalian cytochrome P450s (Cyt P450s) to gradient reversed-phase high-performance…”
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Inter-donor variability of phase I/phase II metabolism of three reference drugs in cryopreserved primary human hepatocytes in suspension and monolayer by den Braver-Sewradj, Shalenie P., den Braver, Michiel W., Vermeulen, Nico P.E., Commandeur, Jan N.M., Richert, Lysiane, Vos, J. Chris

“…Cytochrome P450s (CYPs), UDP-glucuronosyltransferases (UGTs) and sulfotransferases (SULTs) are the most important enzymes for metabolic clearance…”
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Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products by Appiah-Opong, Regina, Commandeur, Jan N.M, van Vugt-Lussenburg, Barbara, Vermeulen, Nico P.E

“…Abstract Curcumin (diferuloylmethane) is a major yellow pigment and dietary component derived from Curcuma longa . It has potent anti-inflammatory,…”
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Selective whole-cell biosynthesis of the designer drug metabolites 15- or 16-betahydroxynorethisterone by engineered Cytochrome P450 BM3 mutants by Reinen, Jelle, Vredenburg, Galvin, Klaering, Karoline, Vermeulen, Nico P.E., Commandeur, Jan N.M., Honing, Maarten, Vos, J. Chris

“…[Display omitted] •CYP BM3 was used as a tool for whole-cell biotransformation of valuable drug metabolites.•CYP BM3 mutants regioselectively convert NET into…”
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Biomarkers of free radical damage: Applications in experimental animals and in humans by de Zwart, Loeckie L, Meerman, John H.N, Commandeur, Jan N.M, Vermeulen, Nico P.E

“…Free radical damage is an important factor in many pathological and toxicological processes. Despite extensive research efforts in biomarkers in recent years,…”
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Application of a cocktail approach to screen cytochrome P450 BM3 libraries for metabolic activity and diversity by Reinen, Jelle, Postma, Geert, Tump, Cornelis, Bloemberg, Tom, Engel, Jasper, Vermeulen, Nico P. E, Commandeur, Jan N. M, Honing, Maarten

“…In the present study, the validity of using a cocktail screening method in combination with a chemometrical data mining approach to evaluate metabolic activity…”
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Activation of the anticancer drugs cyclophosphamide and ifosfamide by cytochrome P450 BM3 mutants by Vredenburg, Galvin, den Braver-Sewradj, Shalenie, van Vugt-Lussenburg, Barbara M.A., Vermeulen, Nico P.E., Commandeur, Jan N.M., Vos, J. Chris

“…•We identified CYP BM3 mutants showing very efficient activation of CPA and IFA.•CYP BM3 mutants showed very low formation of neuro- and nephrotoxic…”
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Characterization of biotransformation enzyme activities in primary rat proximal tubular cells by Schaaf, Gerben J, de Groene, Els M, Maas, Roel F, Commandeur, Jan N.M, Fink-Gremmels, Johanna

“…The proximal tubule is a frequent target for nephrotoxic compounds due to it's ability to transport and accumulate xenobiotics and their metabolites, as well…”
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Interactions between cytochromes P450, glutathione S-transferases and Ghanaian medicinal plants by Appiah-Opong, Regina, Commandeur, Jan N.M., Axson, Civianny, Vermeulen, Nico P.E.

“…Inhibition of cytochrome P450s (CYPs) is a major cause of adverse drug-drug interactions. Alternatively, inhibition of glutathione S-transferases (GSTs) may…”
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Cytochrome P450 bio-affinity detection coupled to gradient HPLC: On-line screening of affinities to cytochrome P4501A2 and 2D6 by Kool, Jeroen, van Liempd, Sebastiaan M., Harmsen, Stefan, Beckman, Joran, van Elswijk, Danny, Commandeur, Jan. N.M., Irth, Hubertus, Vermeulen, Nico P.E.

“…Here we describe novel on-line human CYP1A2 and CYP2D6 Enzyme Affinity Detection (EAD) systems coupled to gradient HPLC. The use of the systems lies in the…”
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Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism by Keizers, Peter H.J., Lussenburg, Barbara M.A., de Graaf, Chris, Mentink, Letty M., Vermeulen, Nico P.E., Commandeur, Jan N.M.

“…The polymorphic human debrisoquine hydroxylase, cytochrome P450 2D6 (CYP2D6), is one of the most important phase I drug metabolising enzymes. It is responsible…”
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