Search Results - "Commandeur, Jan N. M"

A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies by Ramaiahgari, Sreenivasa C., den Braver, Michiel W., Herpers, Bram, Terpstra, Valeska, Commandeur, Jan N. M., van de Water, Bob, Price, Leo S.

“…Immortalized hepatocyte cell lines show only a weak resemblance to primary hepatocytes in terms of gene expression and function, limiting their value in…”
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Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol by Frydenvang, Karla, Verkade-Vreeker, Marlies C A, Dohmen, Floor, Commandeur, Jan N M, Rafiq, Maria, Mirza, Osman, Jørgensen, Flemming Steen, Geerke, Daan P

“…The bacterial Cytochrome P450 (CYP) BM3 (CYP102A1) is one of the most active CYP isoforms. BM3 mutants can serve as a model for human drug-metabolizing CYPs…”
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Biosynthesis of a steroid metabolite by an engineered Rhodococcus erythropolis strain expressing a mutant cytochrome P450 BM3 enzyme by Venkataraman, Harini, te Poele, Evelien M, Rosłoniec, Kamila Z, Vermeulen, Nico, Commandeur, Jan N. M, van der Geize, Robert, Dijkhuizen, Lubbert

“…In the present study, the use of Rhodococcus erythropolis mutant strain RG9 expressing the cytochrome P450 BM3 mutant M02 enzyme has been evaluated for…”
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Reduction and Scavenging of Chemically Reactive Drug Metabolites by NAD(P)H:Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 and Variability in Hepatic Concentrations by den Braver-Sewradj, Shalenie P, den Braver, Michiel W, Toorneman, Robin M, van Leeuwen, Stephanie, Zhang, Yongjie, Dekker, Stefan J, Vermeulen, Nico P. E, Commandeur, Jan N. M, Vos, J. Chris

“…Detoxicating enzymes NAD­(P)­H:quinone oxidoreductase 1 (NQO1) and NRH:quinone oxidoreductase 2 (NQO2) catalyze the two-electron reduction of quinone-like…”
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Linear Interaction Energy Based Prediction of Cytochrome P450 1A2 Binding Affinities with Reliability Estimation by Capoferri, Luigi, Verkade-Vreeker, Marlies C A, Buitenhuis, Danny, Commandeur, Jan N M, Pastor, Manuel, Vermeulen, Nico P E, Geerke, Daan P

“…Prediction of human Cytochrome P450 (CYP) binding affinities of small ligands, i.e., substrates and inhibitors, represents an important task for predicting…”
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Application of a cocktail approach to screen cytochrome P450 BM3 libraries for metabolic activity and diversity by Reinen, Jelle, Postma, Geert, Tump, Cornelis, Bloemberg, Tom, Engel, Jasper, Vermeulen, Nico P. E, Commandeur, Jan N. M, Honing, Maarten

“…In the present study, the validity of using a cocktail screening method in combination with a chemometrical data mining approach to evaluate metabolic activity…”
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Human NAD(P)H:quinone Oxidoreductase 1 (NQO1)-Mediated Inactivation of Reactive Quinoneimine Metabolites of Diclofenac and Mefenamic Acid by Vredenburg, Galvin, Elias, Naura S, Venkataraman, Harini, Hendriks, Delilah F. G, Vermeulen, Nico P. E, Commandeur, Jan N. M, Vos, J. Chris

“…NAD(P)H:quinone oxidoreductase 1 (NQO1) is an enzyme capable of reducing a broad range of chemically reactive quinones and quinoneimines (QIs) and can be…”
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Diclofenac inhibits tumor necrosis factor‐α‐induced nuclear factor‐κB activation causing synergistic hepatocyte apoptosis by Fredriksson, Lisa, Herpers, Bram, Benedetti, Giulia, Matadin, Quraisha, Puigvert, Jordi C., de Bont, Hans, Dragovic, Sanja, Vermeulen, Nico P.E., Commandeur, Jan N.M., Danen, Erik, de Graauw, Marjo, van de Water, Bob

“…Drug‐induced liver injury (DILI) is an important clinical problem. It involves crosstalk between drug toxicity and the immune system, but the exact mechanism…”
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Cytochrome P450-Mediated Bioactivation of Mefenamic Acid to Quinoneimine Intermediates and Inactivation by Human Glutathione S‑Transferases by Venkataraman, Harini, den Braver, Michiel W, Vermeulen, Nico P. E, Commandeur, Jan N. M

“…Mefenamic acid (MFA) has been associated with rare but severe cases of hepatotoxicity, nephrotoxicity, gastrointestinal toxicity, and hypersensitivity…”
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AMAP, the alleged non-toxic isomer of acetaminophen, is toxic in rat and human liver by Hadi, Mackenzie, Dragovic, Sanja, van Swelm, Rachel, Herpers, Bram, van de Water, Bob, Russel, Frans G. M., Commandeur, Jan N. M., Groothuis, Geny M. M.

“…N -acetyl-meta-aminophenol (AMAP) is generally considered as a non-toxic regioisomer of the well-known hepatotoxicant acetaminophen (APAP). However, so far,…”
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Mass Spectrometric Characterization of Protein Adducts of Multiple P450-Dependent Reactive Intermediates of Diclofenac to Human Glutathione‑S‑transferase P1‑1 by Boerma, Jan Simon, Dragovic, Sanja, Vermeulen, Nico P. E, Commandeur, Jan N. M

“…Use of the nonsteroidal anti-inflammatory drug diclofenac (DF) is associated with serious idiosyncratic hepatotoxicity. Covalent binding of reactive…”
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Effect of Human Glutathione S‑Transferases on Glutathione-Dependent Inactivation of Cytochrome P450-Dependent Reactive Intermediates of Diclofenac by Dragovic, Sanja, Boerma, Jan Simon, Vermeulen, Nico P. E, Commandeur, Jan N. M

“…Idiosyncratic adverse drug reactions due to the anti-inflammatory drug diclofenac have been proposed to be caused by the generation of reactive acyl…”
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Characterization of Human Cytochrome P450s Involved in the Bioactivation of Tri-ortho-cresyl Phosphate (ToCP) by Reinen, Jelle, Nematollahi, Leyla, Fidder, Alex, Vermeulen, Nico P. E, Noort, Daan, Commandeur, Jan N. M

“…Tri-ortho-cresyl phosphate (ToCP) is a multipurpose organophosphorus compound that is neurotoxic and suspected to be involved in aerotoxic syndrome in humans…”
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Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets? by Ortega Ugalde, Sandra, Boot, Maikel, Commandeur, Jan N. M., Jennings, Paul, Bitter, Wilbert, Vos, J. Chris

“…This review covers the current knowledge of the cytochrome P450 enzymes (CYPs) of the human pathogen Mycobacterium tuberculosis (Mtb) and their endogenous…”
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Liquid Chromatography/Tandem Mass Spectrometry Detection of Covalent Binding of Acetaminophen to Human Serum Albumin by DAMSTEN, Micaela C, COMMANDEUR, Jan N. M, FIDDER, Alex, HULST, Albert G, TOUW, Daan, NOORT, Daan, VERMEULEN, Nico P. E

“…Covalent binding of reactive electrophilic intermediates to proteins is considered to play an important role in the processes leading to adverse drug reactions…”
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Determination and identification of estrogenic compounds generated with biosynthetic enzymes using hyphenated screening assays, high resolution mass spectrometry and off-line NMR by de Vlieger, Jon S.B., Kolkman, Ard J., Ampt, Kirsten A.M., Commandeur, Jan N.M., Vermeulen, Nico P.E., Kool, Jeroen, Wijmenga, Sybren S., Niessen, Wilfried M.A., Irth, Hubertus, Honing, Maarten

“…This paper describes the determination and identification of active and inactive estrogenic compounds produced by biosynthetic methods. A hyphenated screening…”
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Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models by Capinha, Liliana, Zhang, Yaran, Holzer, Anna-Katharina, Ückert, Anna-Katharina, Zana, Melinda, Carta, Giada, Murphy, Cormac, Baldovini, Jenna, Mazidi, Zahra, Grillari, Johannes, Dinnyes, Andras, van de Water, Bob, Leist, Marcel, Commandeur, Jan N. M., Jennings, Paul

“…Environmental or occupational exposure of humans to trichloroethylene (TCE) has been associated with different extrahepatic toxic effects, including…”
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Enzyme-Catalyzed Activation of Anticancer Prodrugs by Rooseboom, Martijn, Commandeur, Jan N M, Vermeulen, Nico P E

“…The rationale for the development of prodrugs relies upon delivery of higher concentrations of a drug to target cells compared to administration of the drug…”
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Trimethoprim: Novel Reactive Intermediates and Bioactivation Pathways by Cytochrome P450s by Damsten, Micaela C, de Vlieger, Jon S. B, Niessen, Wilfried M. A, Irth, Hubertus, Vermeulen, Nico P. E, Commandeur, Jan N. M

“…Trimethoprim (TMP) is a widely used antibacterial agent that is usually considered as a safe drug. TMP has, however, been implicated in rare adverse drug…”
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Homology Modeling of Rat and Human Cytochrome P450 2D (CYP2D) Isoforms and Computational Rationalization of Experimental Ligand-Binding Specificities by Venhorst, Jennifer, ter Laak, Antonius M, Commandeur, Jan N. M, Funae, Yoshihiko, Hiroi, Toyoko, Vermeulen, Nico P. E

“…The ligand-binding characteristics of rat and human CYP2D isoforms, i.e., rat CYP2D1−4 and human CYP2D6, were investigated by measuring IC50 values of 11 known…”
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