Search Results - "Comley, A."

Extreme Hardening of Pb at High Pressure and Strain Rate by Krygier, A, Powell, P D, McNaney, J M, Huntington, C M, Prisbrey, S T, Remington, B A, Rudd, R E, Swift, D C, Wehrenberg, C E, Arsenlis, A, Park, H-S, Graham, P, Gumbrell, E, Hill, M P, Comley, A J, Rothman, S D

“…We study the high-pressure strength of Pb and Pb-4wt%Sb at the National Ignition Facility. We measure Rayleigh-Taylor growth of preformed ripples ramp…”
Get full text

The application of positron emission tomography (PET) imaging in CNS drug development by Suridjan, Ivonne, Comley, Robert A., Rabiner, Eugenii A

“…As drug discovery and development in Neuroscience push beyond symptom management to disease modification, neuroimaging becomes a key area of translational…”
Get full text

Grain-size-independent plastic flow at ultrahigh pressures and strain rates by Park, H-S, Rudd, R E, Cavallo, R M, Barton, N R, Arsenlis, A, Belof, J L, Blobaum, K J M, El-dasher, B S, Florando, J N, Huntington, C M, Maddox, B R, May, M J, Plechaty, C, Prisbrey, S T, Remington, B A, Wallace, R J, Wehrenberg, C E, Wilson, M J, Comley, A J, Giraldez, E, Nikroo, A, Farrell, M, Randall, G, Gray, 3rd, G T

“…A basic tenet of material science is that the flow stress of a metal increases as its grain size decreases, an effect described by the Hall-Petch relation…”
Get full text

An approach for the measurement of the bulk temperature of single crystal diamond using an X-ray free electron laser by Descamps, A., Ofori-Okai, B. K., Appel, K., Cerantola, V., Comley, A., Eggert, J. H., Fletcher, L. B., Gericke, D. O., Göde, S., Humphries, O., Karnbach, O., Lazicki, A., Loetzsch, R., McGonegle, D., Palmer, C. A. J., Plueckthun, C., Preston, T. R., Redmer, R., Senesky, D. G., Strohm, C., Uschmann, I., White, T. G., Wollenweber, L., Monaco, G., Wark, J. S., Hastings, J. B., Zastrau, U., Gregori, G., Glenzer, S. H., McBride, E. E.

“…We present a method to determine the bulk temperature of a single crystal diamond sample at an X-Ray free electron laser using inelastic X-ray scattering. The…”
Get full text

Inelastic response of silicon to shock compression by Higginbotham, A., Stubley, P. G., Comley, A. J., Eggert, J. H., Foster, J. M., Kalantar, D. H., McGonegle, D., Patel, S., Peacock, L. J., Rothman, S. D., Smith, R. F., Suggit, M. J., Wark, J. S.

“…The elastic and inelastic response of [001] oriented silicon to laser compression has been a topic of considerable discussion for well over a decade, yet there…”
Get full text

Support for dopaminergic hypoactivity in restless legs syndrome: a PET study on D2-receptor binding by Červenka, Simon, Pålhagen, Sven E., Comley, Robert A., Panagiotidis, Georgios, Cselényi, Zsolt, Matthews, Julian C., Lai, Robert Y., Halldin, Christer, Farde, Lars

“…Clinical observations support a central role of the dopamine system in restless legs syndrome (RLS) but previous imaging studies of striatal dopamine…”
Get full text

Lattice-level observation of the elastic-to-plastic relaxation process with subnanosecond resolution in shock-compressed Ta using time-resolved in situ Laue diffraction by Wehrenberg, C. E., Comley, A. J., Barton, N. R., Coppari, F., Fratanduono, D., Huntington, C. M., Maddox, B. R., Park, H.-S., Plechaty, C., Prisbrey, S. T., Remington, B. A., Rudd, R. E.

“…We report direct lattice level measurements of plastic relaxation kinetics through time-resolved, in-situ Laue diffraction of shock-compressed single-crystal…”
Get full text

Evaluation of a semi-automated approach for FDG PET image analysis for routine clinical application in patients with multiple myeloma by Wellman, Tyler J, Mudd, Sarah R, Godby, Kelly N, Wooten, Dustin W, Ross, Jeremy A, Bueno, Orlando F, Wanik, Danielle, Divgi, Chaitanya R, Comley, Robert A, Costa, Luciano J, Hesterman, Jacob Y

“…•Semi-automated 18F-FDG PET image analysis may aid measuring MM treatment response.•Semi-automated and reader-driven PET image analyses agreed in most SULpeak…”
Get full text

Evaluation of 18F-RO-948 PET for Quantitative Assessment of Tau Accumulation in the Human Brain by Kuwabara, Hiroto, Comley, Robert A, Borroni, Edilio, Honer, Michael, Kitmiller, Kelly, Roberts, Joshua, Gapasin, Lorena, Mathur, Anil, Klein, Gregory, Wong, Dean F

“…The availability of tau PET radioligands enables quantitative assessment of tau density and distribution in the human brain. We evaluated the kinetics of a…”
Get full text

Investigating off-Hugoniot states using multi-layer ring-up targets by McGonegle, D., Heighway, P. G., Sliwa, M., Bolme, C. A., Comley, A. J., Dresselhaus-Marais, L. E., Higginbotham, A., Poole, A. J., McBride, E. E., Nagler, B., Nam, I., Seaberg, M. H., Remington, B. A., Rudd, R. E., Wehrenberg, C. E., Wark, J. S.

“…Laser compression has long been used as a method to study solids at high pressure. This is commonly achieved by sandwiching a sample between two diamond anvils…”
Get full text

Strength of shock-loaded single-crystal tantalum [100] determined using in situ broadband x-ray Laue diffraction by Comley, A J, Maddox, B R, Rudd, R E, Prisbrey, S T, Hawreliak, J A, Orlikowski, D A, Peterson, S C, Satcher, J H, Elsholz, A J, Park, H-S, Remington, B A, Bazin, N, Foster, J M, Graham, P, Park, N, Rosen, P A, Rothman, S R, Higginbotham, A, Suggit, M, Wark, J S

“…The strength of shock-loaded single crystal tantalum [100] has been experimentally determined using in situ broadband x-ray Laue diffraction to measure the…”
Get full text

Unexpectedly high affinity of a novel histamine H3 receptor antagonist, GSK239512, in vivo in human brain, determined using PET by Ashworth, S, Berges, A, Rabiner, E A, Wilson, A A, Comley, R A, Lai, R Y K, Boardley, R, Searle, G, Gunn, R N, Laruelle, M, Cunningham, V J

“…Background and Purpose This study aimed to investigate the relationship between the plasma concentration (PK) of the novel histamine H3 receptor antagonist,…”
Get full text

Characterization of 3 Novel Tau Radiopharmaceuticals, 11C-RO-963, 11C-RO-643, and 18F-RO-948, in Healthy Controls and in Alzheimer Subjects by Wong, Dean F, Comley, Robert A, Kuwabara, Hiroto, Rosenberg, Paul B, Resnick, Susan M, Ostrowitzki, Susanne, Vozzi, Cristina, Boess, Frank, Oh, Esther, Lyketsos, Constantine G, Honer, Michael, Gobbi, Luca, Klein, Gregory, George, Noble, Gapasin, Lorena, Kitzmiller, Kelly, Roberts, Josh, Sevigny, Jeff, Nandi, Ayon, Brasic, James, Mishra, Chakradhar, Thambisetty, Madhav, Mogekar, Abhay, Mathur, Anil, Albert, Marilyn, Dannals, Robert F, Borroni, Edilio

“…11 C-RO-963, 11 C-RO-643, and 18 F-RO-948 (previously referred to as 11 C-RO6924963, 11 C-RO6931643, and 18 F-RO6958948, respectively) have been reported as…”
Get full text

A Comparison of Magnetic Resonance Imaging Methods to Assess Multiple Sclerosis Lesions: Implications for Patient Characterization and Clinical Trial Design by Haacke, Ewart Mark, Bernitsas, Evanthia, Subramanian, Karthik, Utriainen, David, Palutla, Vinay Kumar, Yerramsetty, Kiran, Kumar, Prashanth, Sethi, Sean K, Chen, Yongsheng, Latif, Zahid, Jella, Pavan, Gharabaghi, Sara, Wang, Ying, Zhang, Xiaomeng, Comley, Robert A, Beaver, John, Luo, Yanping

“…Magnetic resonance imaging (MRI) is a sensitive imaging modality for identifying inflammatory and/or demyelinating lesions, which is critical for a clinical…”
Get full text

Measurements of electron transport in foils irradiated with a picosecond time scale laser pulse by Brown, C R D, Hoarty, D J, James, S F, Swatton, D, Hughes, S J, Morton, J W, Guymer, T M, Hill, M P, Chapman, D A, Andrew, J E, Comley, A J, Shepherd, R, Dunn, J, Chen, H, Schneider, M, Brown, G, Beiersdorfer, P, Emig, J

“…The heating of solid foils by a picosecond time scale laser pulse has been studied by using x-ray emission spectroscopy. The target material was plastic foil…”
Get full text

Positron emission tomography measurement of brain MAO-B inhibition in patients with Alzheimer’s disease and elderly controls after oral administration of sembragiline by Sturm, Stefan, Forsberg, Anton, Nave, Stephane, Stenkrona, Per, Seneca, Nicholas, Varrone, Andrea, Comley, Robert A., Fazio, Patrik, Jamois, Candice, Nakao, Ryuji, Ejduk, Zbigniew, Al-Tawil, Nabil, Akenine, Ulrika, Halldin, Christer, Andreasen, Niels, Ricci, Benedicte

“…Purpose In Alzheimer’s disease (AD), increased metabolism of monoamines by monoamine oxidase type B (MAO-B) leads to the production of toxic reactive oxygen…”
Get full text

Test–retest variability and reference region-based quantification of 18F-BCPP-EF for imaging mitochondrial complex I in the human brain by Mansur, Ayla, Rabiner, Eugenii A, Tsukada, Hideo, Comley, Robert A, Lewis, Yvonne, Huiban, Mickael, Passchier, Jan, Gunn, Roger N

“…Mitochondrial complex I (MC-I) is an essential regulator of brain bioenergetics and can be quantified in the brain using PET radioligand 18F-BCPP-EF. Here we…”
Get full text

Comley et al. reply by Comley, A J, Maddox, B R, Rudd, R E, Barton, N R, Wehrenberg, C E, Prisbrey, S T, Hawreliak, J A, Orlikowski, D A, Peterson, S C, Satcher, J H, Elsholz, A J, Park, H-S, Remington, B A, Bazin, N, Foster, J M, Graham, P, Park, N, Rosen, P A, Rothman, S D, Higginbotham, A, Suggit, M, Wark, J S

Get full text

Synaptic Changes in Parkinson Disease Assessed with in vivo Imaging by Matuskey, David, Tinaz, Sule, Wilcox, Kyle C., Naganawa, Mika, Toyonaga, Takuya, Dias, Mark, Henry, Shannan, Pittman, Brian, Ropchan, Jim, Nabulsi, Nabeel, Suridjan, Ivonne, Comley, Robert A., Huang, Yiyun, Finnema, Sjoerd J., Carson, Richard E.

“…Objective Parkinson disease is characterized by motor and nonmotor symptoms, reduced striatal dopamine signaling, and loss of dopamine neurons in the…”
Get full text

A Comparison of Gray Matter Density in Restless Legs Syndrome Patients and Matched Controls Using Voxel-Based Morphometry by Comley, Robert A., Cervenka, Simon, Palhagen, Sven E., Panagiotidis, Georgios, Matthews, Julian C., Lai, Robert Y., Halldin, Christer, Farde, Lars, Nichols, Thomas E., Whitcher, Brandon J.

“…ABSTRACT BACKGROUND Restless legs syndrome (RLS) is a common neurological disorder the pathophysiology of which is incompletely understood. Four studies have…”
Get full text