Search Results - "Comis, S D"

A role for pneumolysin but not neuraminidase in the hearing loss and cochlear damage induced by experimental pneumococcal meningitis in guinea pigs by WINTER, A. J, COMIS, S. D, OSBORNE, M. P, TARLOW, M. J, STEPHEN, J, ANDREW, P. W, HILL, J, MITCHELL, T. J

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Cross-links between stereocilia in the guinea pig organ of Corti, and their possible relation to sensory transduction by Pickles, J O, Comis, S D, Osborne, M P

“…Hair cells of the guinea pig cochlea were preserved for electron microscopic examination by fixing in glutaraldehyde without the use of osmium. An extensive…”
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The Auditory Brainstem Response of Aged Guinea Pigs by INGHAM, N. J, THORNTON, S. K, COMIS, S. D, WITHINGTON, D. J

“…The Auditory Brainstem Response (ABR) technique was used to investigate potential dysfunctions in the auditory brainstem of the pigmented guinea pig (Cavia…”
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Ependymal cells of the choroid plexus express tumour necrosis factor-alpha by Tarlow, M J, Jenkins, R, Comis, S D, Osborne, M P, Stephens, S, Stanley, P, Crocker, J

“…Tumour necrosis factor-alpha (TNF alpha) is a major proinflammatory cytokine which appears in the cerebrospinal fluid very early after endotoxin challenge, and…”
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Possible Involvement of Nitric Oxide in the Sensorineural Hearing Loss of Bacterial Meningitis by Amaee, Farzin Robert, Comis, Spiro D., Osborne, Michael P., Drew, Shelley, Tarlow, Michael J.

“…Amaee FR, Comis SD, Osborne MP, Drew S, Tarlow MJ. Possible involvement of nitric oxide in the sensorineural hearing loss of bacteria! meningitis. Acta…”
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Endotoxin induced damage to the cochlea in guinea pigs by Tarlow, M J, Comis, S D, Osborne, M P

“…An apparently unique form of cochlear damage was produced in guinea pigs by perfusing the cochlea or injecting the cerebrospinal fluid with bacterial…”
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The cochlear lesion in experimental bacterial meningitis of the rabbit by OSBORNE, M. P, COMIS, S. D, TARLOW, M. J, STEPHEN, J

“…Sensorineural hearing loss was studied in a rabbit model of experimental bacterial meningitis using electrophysiological and ultrastructural techniques…”
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Hair Cell Loss in the Aged Guinea Pig Cochlea by INGHAM, N. J, COMIS, S. D, WITHINGTON, D. J

“…The various effects of ageing on the auditory system, collectively termed presbycusis, are being studied across a wide range of animal species, including…”
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Ototoxicity resulting from intracochlear perfusion of Streptococcus pneumoniae in the guinea pig is modified by cefotaxime or amoxycillin pretreatment by Winter, A.J., Comis, S.D., Osborne, M.P., Hayward, T.L., Stephen, J., Tarlow, M.J.

“…Acute changes in the electrophysiology and ultrastructure of the organ of Corti were studied after microperfusion of c. 5 × 10 6 CFU of serotype 2…”
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Cytotoxic effects on hair cells of guinea pig cochlea produced by pneumolysin, the thiol activated toxin of Streptococcus pneumoniae by Comis, S D, Osborne, M P, Stephen, J, Tarlow, M J, Hayward, T L, Mitchell, T J, Andrew, P W, Boulnois, G J

“…The cytolytic toxin, pneumolysin, from the gram positive bacterium, Streptococcus pneumoniae, when perfused through the scala tympani of the guinea pig cochlea…”
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Vulnerability of tip links between stereocilia to acoustic trauma in the guinea pig by Pickles, J O, Osborne, M P, Comis, S D

“…The cochleae of anaesthetized guinea pigs were prepared for scanning electron microscopy, immediately after exposure to an intense tone. Stereocilia on hair…”
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Further observations on the fine structure of tip links between stereocilia of the guinea pig cochlea by Osborne, M P, Comis, S D, Pickles, J O

“…Stereocilia of the guinea pig organ of Corti were examined by transmission electron microscopy, after fixation in glutaraldehyde and tannic acid, and…”
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Effect of furosemide upon morphology of hair bundles in guinea pig cochlear hair cells by Comis, S D, Osborne, M P, Jeffries, D J

“…Furosemide was administered by intraperitoneal injection and intracochlear perfusion. The peak-to-peak amplitude of the cochlear microphonic at high sound…”
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Morphology and cross-linkage of stereocilia in the guinea-pig labyrinth examined without the use of osmium as a fixative by OSBORNE, M. P, COMIS, S. D, PICKLES, J. O

“…Hair cells of the guinea-pig cochlea and vestibular system were prepared for electron-microscopic examination by fixing in glutaraldehyde without the use of…”
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The organization of tip links and stereocilia on hair cells of bird and lizard basilar papillae by Pickles, J O, Brix, J, Comis, S D, Gleich, O, Köppl, C, Manley, G A, Osborne, M P

“…Auditory papillae from three species of bird (pigeon, starling, and chick), and two species of European lizard (Podarcis muralis and Podarcis sicula) were…”
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Action of elastase, collagenase and other enzymes upon linkages between stereocilia in the guinea-pig cochlea by Osborne, M P, Comis, S D

“…Enzymes, which degrade elements of the extracellular environment, were studied for their actions upon stereocilia and their cross-linkages by scanning electron…”
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Preparation of inner ear sensory hair bundles for high resolution scanning electron microscopy by Osborne, M P, Comis, S D

“…Chemical fixation techniques for preservation of sensory hair bundles in the mammalian inner ear for scanning electron microscopy (SEM) are reviewed. Fixatives…”
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Is myosin in the cochlea a basis for active motility? by Macartney, J. C, Comis, S. D, Pickles, J. O

“…Recent evidence suggests that the stereocilia of cochlear hair cells contain actin filaments. The experiments reported here demonstrate the presence of myosin,…”
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Action of putative neurotransmitters in the guinea pig cochlea by Comis, S D, Leng, G

“…Scala tympani of the guinea pig was perfused with artificial perilymph containing putative transmitter substances. Single auditory nerve fibre activity was…”
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Tip-link organization in anomalously-oriented hair cells of the guinea pig cochlea by Comis, S D, Pickles, J O, Osborne, M P, Pepper, C B

“…Stereocilia are described in a group of guinea pigs with abnormal conformation of the outer hair cell stereociliary bundles. Rows of stereocilia were found…”
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