Search Results - "Comfort, Nicole"

Sex-specific neurotoxic effects of heavy metal pollutants: Epidemiological, experimental evidence and candidate mechanisms by Gade, Meethila, Comfort, Nicole, Re, Diane B.

“…The heavy metals lead (Pb), mercury (Hg), and cadmium (Cd) are ubiquitous environmental pollutants and are known to exert severe adverse impacts on the nervous…”
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Short-term air pollution and temperature exposure and changes in the extracellular microRNA profile of Normative Aging Study (NAS) participants by Danesh Yazdi, Mahdieh, Nassan, Feiby L., Kosheleva, Anna, Wang, Cuicui, Xu, Zongli, Di, Qian, Requia, Weeberb J, Comfort, Nicole T., Wu, Haotian, Laurent, Louise C., DeHoff, Peter, Vokonas, Pantel, Baccarelli, Andrea A., Schwartz, Joel D.

“…[Display omitted] •Extracellular miRNAs play a role in gene expression and cell-to-cell communication.•Short-term exposure to pollutants and temperature…”
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The association between toenail metals and extracellular MicroRNAs (ex-miRNAs) among the participants of the Normative Aging study (NAS) by Danesh Yazdi, Mahdieh, Sonntag, Allison, Kosheleva, Anna, Nassan, Feiby L., Wang, Cuicui, Xu, Zongli, Wu, Haotian, Laurent, Louise C., DeHoff, Peter, Comfort, Nicole T., Vokonas, Pantel, Wright, Robert, Weisskopf, Marc, Baccarelli, Andrea A., Schwartz, Joel D.

“…Mechanistic studies of the effects of environmental risk factors have been exploring the potential role of microRNA(miRNAs) as a possible pathway to clinical…”
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Intermediate and long-term exposure to air pollution and temperature and the extracellular microRNA profile of participants in the normative aging study (NAS) by Danesh Yazdi, Mahdieh, Nassan, Feiby L., Kosheleva, Anna, Wang, Cuicui, Xu, Zongli, Di, Qian, Requia, Weeberb J., Comfort, Nicole T., Wu, Haotian, Laurent, Louise C., DeHoff, Peter, Vokonas, Pantel, Baccarelli, Andrea A., Schwartz, Joel D.

“…The molecular effects of intermediate and long-term exposure to air pollution and temperature, such as those on extracellular microRNA (ex-miRNA) are not well…”
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Longitudinal transcriptomic analysis of mouse sciatic nerve reveals pathways associated with age‐related muscle pathology by Comfort, Nicole, Gade, Meethila, Strait, Madeleine, Merwin, Samantha J., Antoniou, Daphne, Parodi, Chiara, Marcinczyk, Lina, Jean‐Francois, Lea, Bloomquist, Tessa R., Memou, Anna, Rideout, Hardy J., Corti, Stefania, Kariya, Shingo, Re, Diane B.

“…Background Sarcopenia, the age‐associated decline in skeletal muscle mass and strength, has long been considered a disease of muscle only, but accumulating…”
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343 Brain-derived Extracellular Vesicles: A Novel Biomarker of CNS Metals Load with Applications in Identifying Neurodegenerative Diseases by Saxena, Roheeni, Saglimbeni, Brianna, Strait, Madeleine, Alayyoub, Mohammad, Comfort, Nicole, Re, Diane

“…OBJECTIVES/GOALS: This study aims to develop a method to examine whether blood-borne CNS-EV metal cargoes can serve as reliable biomarkers of CNS metal load…”
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BAH domains and a histone-like motif in DNA methyltransferase 1 (DNMT1) regulate de novo and maintenance methylation in vivo by Yarychkivska, Olya, Shahabuddin, Zoha, Comfort, Nicole, Boulard, Mathieu, Bestor, Timothy H.

“…DNA methyltransferase 1 (DNMT1) is a multidomain protein believed to be involved only in the passive transmission of genomic methylation patterns via…”
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Air pollution and human endogenous retrovirus methylation in the school inner-city asthma intervention study by Reddam, Aalekhya, Bollati, Valentina, Wu, Haotian, Favero, Chiara, Tarantini, Letizia, Hoxha, Mirjam, Comfort, Nicole, Gold, Diane R, Phipatanakul, Wanda, Baccarelli, Andrea A

“…Abstract Human endogenous retroviruses (HERVs) are transposable genomic elements generally repressed through DNA methylation. HERVs can be demethylated and…”
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Sex-Specific Neurotoxic Effects of Organophosphate Pesticides Across the Life Course by Comfort, Nicole, Re, Diane B.

“…Purpose of Review This review discusses the sex-specific effects of exposure to various organophosphate (OP) pesticides throughout the life course and…”
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“Message in a Bottle”: Extracellular Vesicle microRNAs as Novel Biomarkers of Environmental Exposures and Health Outcomes by Comfort, Nicole

“…Background: The physiological and pathophysiological roles of secreted membrane-enclosed vesicles known as extracellular vesicles (EVs) have become…”
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Nanoparticle Tracking Analysis for the Quantification and Size Determination of Extracellular Vesicles by Comfort, Nicole, Cai, Kunheng, Bloomquist, Tessa R, Strait, Madeleine D, Ferrante, Jr, Anthony W, Baccarelli, Andrea A

“…The physiological and pathophysiological roles of extracellular vesicles (EVs) have become increasingly recognized, making the EV field a quickly evolving area…”
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Reprogramming cells from Gulf War veterans into neurons to study Gulf War illness by Qiang, Liang, Rao, Anand N, Mostoslavsky, Gustavo, James, Marianne F, Comfort, Nicole, Sullivan, Kimberly, Baas, Peter W

“…Gulf War illness (GWI), which afflicts at least 25% of veterans who served in the 1990–1991 war in the Persian Gulf, is thought to be caused by deployment…”
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Extracellular microRNA and cognitive function in a prospective cohort of older men: The Veterans Affairs Normative Aging Study by Comfort, Nicole, Wu, Haotian, De Hoff, Peter, Vuppala, Aishwarya, Vokonas, Pantel S, Spiro, Avron, Weisskopf, Marc, Coull, Brent A, Laurent, Louise C, Baccarelli, Andrea A, Schwartz, Joel

“…Aging-related cognitive decline is an early symptom of Alzheimer's disease and other dementias, and on its own can have substantial consequences on an…”
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Antisense oligonucleotides extend survival and reverse decrement in muscle response in ALS models by McCampbell, Alex, Cole, Tracy, Wegener, Amy J, Tomassy, Giulio S, Setnicka, Amy, Farley, Brandon J, Schoch, Kathleen M, Hoye, Mariah L, Shabsovich, Mark, Sun, Linhong, Luo, Yi, Zhang, Mingdi, Comfort, Nicole, Wang, Bin, Amacker, Jessica, Thankamony, Sai, Salzman, David W, Cudkowicz, Merit, Graham, Danielle L, Bennett, C Frank, Kordasiewicz, Holly B, Swayze, Eric E, Miller, Timothy M

“…Mutations in superoxide dismutase 1 (SOD1) are responsible for 20% of familial ALS. Given the gain of toxic function in this dominantly inherited disease,…”
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