Search Results - "Comerford, A."

Elucidation of a Universal Size-Control Mechanism in Drosophila and Mammals by Dong, Jixin, Feldmann, Georg, Huang, Jianbin, Wu, Shian, Zhang, Nailing, Comerford, Sarah A., Gayyed, Mariana F., Anders, Robert A., Maitra, Anirban, Pan, Duojia

“…Coordination of cell proliferation and cell death is essential to attain proper organ size during development and for maintaining tissue homeostasis throughout…”
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Apparent age and gender differences in survival optimism: To what extent are they a bias in the translation of beliefs onto a percentage scale? by Comerford, David A

“…Abstract A standard way to elicit expectations asks for the percentage chance an event will occur. Previous research demonstrates noise in reported…”
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Acetate Dependence of Tumors by Comerford, Sarah A., Huang, Zhiguang, Du, Xinlin, Wang, Yun, Cai, Ling, Witkiewicz, Agnes K., Walters, Holly, Tantawy, Mohammed N., Fu, Allie, Manning, H. Charles, Horton, Jay D., Hammer, Robert E., McKnight, Steven L., Tu, Benjamin P.

“…Acetyl-CoA represents a central node of carbon metabolism that plays a key role in bioenergetics, cell proliferation, and the regulation of gene expression…”
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Lin28b Is Sufficient to Drive Liver Cancer and Necessary for Its Maintenance in Murine Models by Nguyen, Liem H., Robinton, Daisy A., Seligson, Marc T., Wu, Linwei, Li, Lin, Rakheja, Dinesh, Comerford, Sarah A., Ramezani, Saleh, Sun, Xiankai, Parikh, Monisha S., Yang, Erin H., Powers, John T., Shinoda, Gen, Shah, Samar P., Hammer, Robert E., Daley, George Q., Zhu, Hao

“…Lin28a/b are RNA-binding proteins that influence stem cell maintenance, metabolism, and oncogenesis. Poorly differentiated, aggressive cancers often…”
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Perceived health inequalities: are the UK and US public aware of occupation-related health inequality, and do they wish to see it reduced? by Bridger, Emma K, Tufte-Hewett, Angela, Comerford, David A

“…One underexamined factor in the study of lay views of socioeconomic health inequalities is occupation-related health. Examining health by occupational social…”
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p53 genes function to restrain mobile elements by Wylie, Annika, Jones, Amanda E, D'Brot, Alejandro, Lu, Wan-Jin, Kurtz, Paula, Moran, John V, Rakheja, Dinesh, Chen, Kenneth S, Hammer, Robert E, Comerford, Sarah A, Amatruda, James F, Abrams, John M

“…Throughout the animal kingdom, p53 genes govern stress response networks by specifying adaptive transcriptional responses. The human member of this gene family…”
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Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed bile duct development and loss of hepatocyte viability; a ribosomopathy-like phenotype that is partially p53-dependent by Comerford, Sarah A, Hinnant, Elizabeth A, Chen, Yidong, Hammer, Robert E

“…Defective ribosome biogenesis (RiBi) underlies a group of clinically diverse human diseases collectively known as the ribosomopathies, core manifestations of…”
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Bondi–Hoyle–Lyttleton accretion by binary stars by Comerford, T A F, Izzard, R G, Booth, R A, Rosotti, G

“…ABSTRACT Binary stars often move through an ambient medium from which they accrete material and angular momentum, as in triple-star systems, star-forming…”
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Acss2/HIF-2 signaling facilitates colon cancer growth and metastasis by Garcia, Joseph A, Chen, Rui, Xu, Min, Comerford, Sarah A, Hammer, Robert E, Melton, Shelby D, Feagins, Linda A

“…The microenvironment of solid tumors is characterized by oxygen and glucose deprivation. Acss2/HIF-2 signaling coordinates essential genetic regulators…”
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The Effects of Curvature and Constriction on Airflow and Energy Loss in Pathological Tracheas by Bates, A.J, Cetto, R, Doorly, D.J, Schroter, R.C, Tolley, N.S, Comerford, A

“…Highlights • Current tracheal surgical guidelines found to neglect important geometric measures • Constriction, curvature, glottal alignment and deviation all…”
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Intimal and medial contributions to the hydraulic resistance of the arterial wall at different pressures: a combined computational and experimental study by Chooi, K. Y., Comerford, A., Sherwin, S. J., Weinberg, P. D.

“…The hydraulic resistances of the intima and media determine water flux and the advection of macromolecules into and across the arterial wall. Despite several…”
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Coupled and reduced dimensional modeling of respiratory mechanics during spontaneous breathing by Ismail, M., Comerford, A., Wall, W. A.

“…SUMMARY In this paper, we develop a total lung model based on a tree of 0D airway and acinar models for studying respiratory mechanics during spontaneous…”
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Tissue‐Engineered Tracheal Replacement in a Child: A 4‐Year Follow‐Up Study by Hamilton, N. J., Kanani, M., Roebuck, D. J., Hewitt, R. J., Cetto, R., Culme‐Seymour, E. J., Toll, E., Bates, A. J., Comerford, A. P., McLaren, C. A., Butler, C. R., Crowley, C., McIntyre, D., Sebire, N. J., Janes, S. M., O'Callaghan, C., Mason, C., De Coppi, P., Lowdell, M. W., Elliott, M. J., Birchall, M. A.

“…In 2010, a tissue‐engineered trachea was transplanted into a 10‐year‐old child using a decellularized deceased donor trachea repopulated with the recipient's…”
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Power loss mechanisms in pathological tracheas by Bates, A.J, Comerford, A, Cetto, R, Schroter, R.C, Tolley, N.S, Doorly, D.J

“…Abstract The effort required to inhale a breath of air is a critically important measure in assessing airway function. Although the contribution of the trachea…”
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Supramolecular Assemblies Showing Thermally Activated Delayed Fluorescence by Comerford, Thomas A., Zysman-Colman, Eli

“…Supramolecular assemblies based on luminescent components offer significant advantages over their discrete counterparts, including improved quantum yields,…”
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A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling by Nagati, Jason S, Xu, Min, Garcia, Trent, Comerford, Sarah A, Hammer, Robert E, Garcia, Joseph A

“…The response to environmental stresses by eukaryotic organisms includes activation of protective biological mechanisms, orchestrated in part by transcriptional…”
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An acetate switch regulates stress erythropoiesis by Xu, Min, Nagati, Jason S, Xie, Jian, Li, Jiwen, Walters, Holly, Moon, Young-Ah, Gerard, Robert D, Huang, Chou-Long, Comerford, Sarah A, Hammer, Robert E, Horton, Jay D, Chen, Rui, Garcia, Joseph A

“…Manipulation of acetate levels in mice can affect the activity of the hypoxia-responsive transcription factor HIF-2α and facilitate recovery from anemia. The…”
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Coupling strategies for biomedical fluid-structure interaction problems by Küttler, U., Gee, M., Förster, Ch, Comerford, A., Wall, W. A.

“…The coupling of lightweight and often thin‐walled structures to fluids in an incompressible regime is a recurring theme in biomechanics. There are many…”
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SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer by Suresh, Shruthy, Durakoglugil, Deniz, Zhou, Xiaorong, Zhu, Bokai, Comerford, Sarah A, Xing, Chao, Xie, Xian-Jin, York, Brian, O'Donnell, Kathryn A

“…Hepatocellular carcinoma (HCC) is the fifth most common solid tumor in the world and the third leading cause of cancer-associated deaths. A Sleeping…”
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Controls on geothermal heat recovery from a hot sedimentary aquifer in Guardbridge, Scotland: Field measurements, modelling and long term sustainability by Comerford, A., Fraser-Harris, A., Johnson, G., McDermott, C.I.

“…•Fault architecture determined from detailed field fracture mapping.•DFN modelling of potential HSA in fault damage zone of regional scale fault.•First 3D…”
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