Search Results - "Comer, Frank"

HER2-targeted antibody-drug conjugate induces host immunity against cancer stem cells by Xia, Leiming, Wen, Lu, Qin, You, Dobson, Hannah E, Zhang, Tao, Comer, Frank I, Hinrichs, Mary Jane, Oberst, Michael D, Coats, Steven R, Chang, Alfred E, Liu, Yuanyuan, Bao, Yangyi, Dai, Fu, Wicha, Max S, Li, Qiao

“…We previously tested HER2-targeted antibody-drug conjugates (ADCs) in immunocompromised (SCID) mice, precluding evaluation of host immunity, impact on cancer…”
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TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium by Lee, Susan, Comer, Frank I, Sasaki, Atsuo, McLeod, Ian X, Duong, Yung, Okumura, Koichi, Yates, 3rd, John R, Parent, Carole A, Firtel, Richard A

“…Dictyostelium cells form a multicellular organism through the aggregation of independent cells. This process requires both chemotaxis and signal relay in which…”
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Reciprocity between O-GlcNAc and O-Phosphate on the Carboxyl Terminal Domain of RNA Polymerase II by Comer, Frank I, Hart, Gerald W

“…The carboxyl terminal domain of RNA polymerase II has multiple essential roles in transcription initiation, promoter clearance, transcript elongation, and the…”
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Phosphoinositides Specify Polarity during Epithelial Organ Development by Comer, Frank I., Parent, Carole A.

“…The molecular mechanisms that integrate cellular polarity with tissue architecture during epithelial morphogenesis are poorly understood. Using a…”
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PI 3-Kinases and PTEN: How Opposites Chemoattract by Comer, Frank I., Parent, Carole A.

“…Phosphatidylinositol lipids, such as PI(4,5)P 2 and PI(3,4,5)P 3, are key mediators in diverse intracellular signaling pathways. Two recent reports examine how…”
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O-GlcNAc Transferase Is in a Functional Complex with Protein Phosphatase 1 Catalytic Subunits by Wells, Lance, Kreppel, Lisa K., Comer, Frank I., Wadzinski, Brian E., Hart, Gerald W.

“…A hallmark of signal transduction is the dynamic and inducible post-translational modification of proteins. In addition to the well characterized…”
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Dynamic interplay between O-glycosylation and O-phosphorylation of nucleocytoplasmic proteins: alternative glycosylation/phosphorylation of THR-58, a known mutational hot spot of c-Myc in lymphomas, is regulated by mitogens by Kamemura, Kazuo, Hayes, Bradley K, Comer, Frank I, Hart, Gerald W

“…Previously, we reported that c-Myc is glycosylated by O-linked N-acetylglucosamine at Thr-58, a known phosphorylation site and a mutational hot spot in…”
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Phosphoinositide 3-kinase activity controls the chemoattractant-mediated activation and adaptation of adenylyl cyclase by Comer, Frank I, Parent, Carole A

“…The binding of chemoattractants to cognate G protein-coupled receptors activates a variety of signaling cascades that provide spatial and temporal cues…”
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O-GlcNAc and the control of gene expression by Comer, Frank I, Hart, Gerald W

“…Many eukaryotic proteins contain O-linked N-acetylglucosamine (O-GlcNAc) on their serine and threonine side chain hydroxyls. In contrast to classical cell…”
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The PI3K-Mediated Activation of CRAC Independently Regulates Adenylyl Cyclase Activation and Chemotaxis by Comer, Frank I., Lippincott, Christopher K., Masbad, Joseph J., Parent, Carole A.

“…The ability of a cell to detect an external chemical signal and initiate a program of directed migration along a gradient comprises the fundamental process…”
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Localization of the O-GlcNAc transferase and O-GlcNAc-modified proteins in rat cerebellar cortex by Akimoto, Yoshihiro, Comer, Frank I, Cole, Robert N, Kudo, Akihiko, Kawakami, Hayato, Hirano, Hiroshi, Hart, Gerald W

“…O-linked N-acetylglucosamine (O-GlcNAc) is a ubiquitous nucleocytoplasmic protein modification that has a complex interplay with phosphorylation on…”
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Characterization of a Mouse Monoclonal Antibody Specific for O-Linked N-Acetylglucosamine by Comer, Frank I., Vosseller, Keith, Wells, Lance, Accavitti, Mary Ann, Hart, Gerald W.

“…β-O-linked N-acetylglucosamine (O-GlcNAc) is an abundant posttranslational modification of resident nuclear and cytoplasmic proteins in eukaryotes. Increasing…”
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Site-Specific GlcNAcylation of Human Erythrocyte Proteins by Wang, Zihao, Park, Kyoungsook, Comer, Frank, Hsieh-Wilson, Linda C., Saudek, Christopher D., Hart, Gerald W.

“…Site-Specific GlcNAcylation of Human Erythrocyte Proteins Potential Biomarker(s) for Diabetes Zihao Wang 1 , Kyoungsook Park 1 , Frank Comer 1 , Linda C…”
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Proton Transfer in the Mechanism of Triosephosphate Isomerase by Harris, Thomas K, Cole, Robert N, Comer, Frank I, Mildvan, Albert S

“…Triosephosphate isomerase (TIM) catalyzes the reversible interconversion of dihydroxyacetone phosphate (DHAP) and glyceraldehyde 3-phosphate (GAP), with…”
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Abstract 514: Specific anti-HER2 host immunity conferred by HER2-targeted antibody drug conjugate therapy and checkpoint blockade by Qin, You, Dobson, Hannah E., Comer, Frank I., Chang, Alfred E., Wicha, Max S., Li, Qiao

“…Using HER2-targeted antibody drug conjugates (ADC), we tested the therapeutic efficacy, direct impact on cancer stem cells (CSCs), and potential added benefit…”
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Structural insights into the mechanism of action of a biparatopic anti-HER2 antibody by Oganesyan, Vaheh, Peng, Li, Bee, Jared S., Li, John, Perry, Samuel R., Comer, Frank, Xu, Linda, Cook, Kimberly, Senthil, Kannaki, Clarke, Lori, Rosenthal, Kim, Gao, Changshou, Damschroder, Melissa, Wu, Herren, Dall’Acqua, William

“…Pathways of human epidermal growth factor (EGF) receptors are activated upon ligand-dependent or -independent homo- or heterodimerization and their subsequent…”
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Site-Specific GlcNAcylation of Human Erythrocyte Proteins Potential Biomarker(s) for Diabetes by ZIHAO WANG, PARK, Kyoungsook, COMER, Frank, HSIEH-WILSON, Linda C, SAUDEK, Christopher D, HART, Gerald W

“…O-linked N-acetylglucosamine (O-GlcNAc) is upregulated in diabetic tissues and plays a role in insulin resistance and glucose toxicity. Here, we investigated…”
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Abstract LB-297: HER2-targeted antibody drug conjugates induce host immunity and target cancer stem cells and the efficacy can be enhanced by anti-PD-L1 by Xia, Leiming, Wen, Lu, Lin, Ming, Frank, Comer, Jane, Hinrichs Mary, Michael, Oberst, Steven, Coats, Bao, Yangyi, Chang, Alfred E., Wicha, Max, Li, Qiao

“…HER2 represents an ideal target for cancer immunotherapy. HER2-targeted antibody drug conjugate (ADC) was tested in immunocompromised (SCID) host, which…”
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Abstract 4981: HER2-targeted antibody drug conjugates (ADCs) induce host immunity against cancer stem cells and are enhanced by anti-PD-L1 by Xia, Leiming, Wen, Lu, Wu, Gang, Zhang, Tao, Comer, Frank, Hinrichs, Mary Jane Masson, Oberst, Michael, Coats, Steven R., Chang, Alfred E., Liu, Yuanyuan, Bao, Yangyi, Wicha, Max, Li, Qiao

“…HER2-targeted antibody drug conjugate (ADC) was only tested in immunocompromised (SCID) host, which doesn’t allow the evaluation of the ADC-induced host immune…”
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O-Glycosylation of nuclear and cytosolic proteins. Dynamic interplay between O-GlcNAc and O-phosphate by Comer, F I, Hart, G W

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