Search Results - "Comeglio, P"

Testosterone treatment is associated with reduced adipose tissue dysfunction and nonalcoholic fatty liver disease in obese hypogonadal men by Maseroli, E., Comeglio, P., Corno, C., Cellai, I., Filippi, S., Mello, T., Galli, A., Rapizzi, E., Presenti, L., Truglia, M. C., Lotti, F., Facchiano, E., Beltrame, B., Lucchese, M., Saad, F., Rastrelli, G., Maggi, M., Vignozzi, L.

“…Purpose In both preclinical and clinical settings, testosterone treatment (TTh) of hypogonadism has shown beneficial effects on insulin sensitivity and…”
Get full text

Testosterone does not affect lower urinary tract symptoms while improving markers of prostatitis in men with benign prostatic hyperplasia: a randomized clinical trial by Rastrelli, G., Cipriani, S., Lotti, F., Cellai, I., Comeglio, P., Filippi, S., Boddi, V., Della Camera, P. A., Santi, R., Boni, L., Nesi, G., Serni, S., Gacci, M., Maggi, M., Vignozzi, L.

“…Purpose Benign Prostatic Hyperplasia (BPH) is a result of prostate inflammation, frequently occurring in metabolic syndrome (MetS). Low testosterone is common…”
Get full text

Testosterone positively regulates vagina NO-induced relaxation: an experimental study in rats by Cellai, I., Filippi, S., Comeglio, P., Cipriani, S., Maseroli, E., Di Stasi, V., Todisco, T., Marchiani, S., Tamburrino, L., Villanelli, F., Vezzani, S., Corno, C., Fambrini, M., Guarnieri, G., Sarchielli, E., Morelli, A., Rastrelli, G., Maggi, M., Vignozzi, L.

“…Purpose Female sexual response involves a complex interplay between neurophysiological mechanisms and the nitric oxide (NO)-mediated relaxation of clitoris and…”
Get full text

Treatment potential of LPCN 1144 on liver health and metabolic regulation in a non-genomic, high fat diet induced NASH rabbit model by Comeglio, P., Sarchielli, E., Filippi, S., Cellai, I., Guarnieri, G., Morelli, A., Rastrelli, G., Maseroli, E., Cipriani, S., Mello, T., Galli, A., Bruno, B. J., Kim, K., Vangara, K., Papangkorn, K., Chidambaram, N., Patel, M. V., Maggi, M., Vignozzi, L.

“…Purpose Low free testosterone (T) level in men is independently associated with presence and severity of Non-Alcoholic Steatohepatitis (NASH). The histological…”
Get full text

Therapeutic effects of obeticholic acid (OCA) treatment in a bleomycin-induced pulmonary fibrosis rat model by Comeglio, P., Filippi, S., Sarchielli, E., Morelli, A., Cellai, I., Corno, C., Pini, A., Adorini, L., Vannelli, G. B., Maggi, M., Vignozzi, L.

“…Purpose We recently demonstrated a protective effect of the farnesoid X receptor agonist obeticholic acid (OCA) in rat models of bleomycin-induced pulmonary…”
Get full text

Therapeutic effects of the selective farnesoid X receptor agonist obeticholic acid in a monocrotaline-induced pulmonary hypertension rat model by Comeglio, P., Filippi, S., Sarchielli, E., Morelli, A., Cellai, I., Corno, C., Adorini, L., Vannelli, G. B., Maggi, M., Vignozzi, L.

“…Background Activation of the farnesoid X receptor (FXR), a member of the nuclear receptor steroid superfamily, leads to anti-inflammatory and anti-fibrotic…”
Get full text

Opposite effects of tamoxifen on metabolic syndrome-induced bladder and prostate alterations: A role for GPR30/GPER? by Comeglio, P., Morelli, A., Cellai, I., Vignozzi, L., Sarchielli, E., Filippi, S., Maneschi, E., Corcetto, F., Corno, C., Gacci, M., Vannelli, G.B., Maggi, M.

“…BACKGROUND BPH and LUTS have been associated to obesity, hypogonadism, and metabolic syndrome (MetS). MetS‐induced prostate and bladder alterations, including…”
Get full text

Fibroblast growth factor and endothelin-1 receptors mediate the response of human striatal precursor cells to hypoxia by Ambrosini, S, Sarchielli, E, Comeglio, P, Porfirio, B, Gallina, P, Morelli, A, Vannelli, G.B

“…Highlights • Hypoxia increases HSP cell proliferation at 48 h and reduces cell survival at 72 h. • HSP cells express FGF2 and ET-1 suggesting endogenous…”
Get full text

The revised ghent nosology; reclassifying isolated ectopia lentis by Chandra, A., Patel, D., Aragon-Martin, J.A., Pinard, A., Collod-Béroud, G., Comeglio, P., Boileau, C., Faivre, L., Charteris, D., Child, A.H., Arno, G.

“…Inherited ectopia lentis (EL) is most commonly caused by Marfan syndrome (MFS), a multisystemic disorder caused by mutations in FBN1. Historically the…”
Get full text

Contribution of molecular analyses in diagnosing Marfan syndrome and type I fibrillinopathies: an international study of 1009 probands by Faivre, L, Collod-Beroud, G, Child, A, Callewaert, B, Loeys, B L, Binquet, C, Gautier, E, Arbustini, E, Mayer, K, Arslan-Kirchner, M, Stheneur, C, Kiotsekoglou, A, Comeglio, P, Marziliano, N, Halliday, D, Beroud, C, Bonithon-Kopp, C, Claustres, M, Plauchu, H, Robinson, P N, Adès, L, De Backer, J, Coucke, P, Francke, U, De Paepe, A, Boileau, C, Jondeau, G

“…The diagnosis of Marfan syndrome (MFS) is usually initially based on clinical criteria according to the number of major and minor systems affected following…”
Get more information

Clinical and mutation-type analysis from an international series of 198 probands with a pathogenic FBN1 exons 24-32 mutation by FAIVRE, L, COLLOD-BEROUD, G, STHENEUR, C, KIOTSEKOGLOU, A, COMEGLIO, P, MARZILIANO, N, WOLF, J. E, BOUCHOT, O, KHAU-VAN-KIEN, P, BEROUD, C, CLAUSTRES, M, BONITHON-KOPP, C, CALLEWAERT, B, ROBINSON, P. N, ADES, L, DE BACKER, J, COUCKE, P, FRANCKE, U, DE PAEPE, A, JONDEAU, G, BOILEAU, C, CHILD, A, BINQUET, C, GAUTIER, E, LOEYS, B. L, ARBUSTINI, E, MAYER, K, ARSLAN-KIRCHNER, M

“…Mutations in the FBN1 gene cause Marfan syndrome (MFS) and a wide range of overlapping phenotypes. The severe end of the spectrum is represented by neonatal…”
Get full text

Identification of eight novel VEGFR-3 mutations in families with primary congenital lymphoedema by Evans, A L, Bell, R, Brice, G, Comeglio, P, Lipede, C, Jeffery, S, Mortimer, P, Sarfarazi, M, Child, A H

“…5, 6 The gene for LD has recently been identified as FOXC2 (MFH-1) (MIM 602402), a member of the forkhead/winged-helix family of transcription factors, and…”
Get full text

Pathogenic FBN1 mutations in 146 adults not meeting clinical diagnostic criteria for Marfan syndrome: Further delineation of type 1 fibrillinopathies and focus on patients with an isolated major criterion by Faivre, L., Collod-Beroud, G., Callewaert, B., Child, A., Loeys, B.L., Binquet, C., Gautier, E., Arbustini, E., Mayer, K., Arslan-Kirchner, M., Kiotsekoglou, A., Comeglio, P., Grasso, M., Beroud, C., Bonithon-Kopp, C., Claustres, M., Stheneur, C., Bouchot, O., Wolf, J.E., Robinson, P.N., Adès, L., De Backer, J., Coucke, P., Francke, U., De Paepe, A., Boileau, C., Jondeau, G.

“…Mutations in the FBN1 gene cause Marfan syndrome (MFS) and have been associated with a wide range of milder overlapping phenotypes. A proportion of patients…”
Get full text

Human prostatic urethra expresses vitamin D receptor and responds to vitamin D receptor ligation by Comeglio, P., Chavalmane, A. K., Fibbi, B., Filippi, S., Marchetta, M., Marini, M., Morelli, A., Penna, G., Vignozzi, L., Vannelli, G. B., Adorini, L., Maggi, M.

“…Background : Chronic inflammation is now considered a determinant of benign prostatic hyperplasia (BPH), promoting, together with the hormonal milieu, prostate…”
Get full text

Human prostatic urethra expresses vitamin D receptor and responds to vitamin D receptor ligation by Comeglio, P, Chavalmane, A K, Fibbi, B, Filippi, S, Marchetta, M, Marini, M, Morelli, A, Penna, G, Vignozzi, L, Vannelli, G B, Adorini, L, Maggi, M

“…BACKGROUNDChronic inflammation is now considered a determinant of benign prostatic hyperplasia (BPH), promoting, together with the hormonal milieu, prostate…”
Get full text

Muscle fibrillin deficiency in Marfan’s syndrome myopathy by Behan, W M H, Longman, C, Petty, R K H, Comeglio, P, Child, A H, Boxer, M, Foskett, P, Harriman, D G F

“…Objective: To report a family with Marfan’s syndrome in whom a myopathy was associated with respiratory failure; muscle biopsies from affected individuals were…”
Get full text

Marfan syndrome in South Africa: a molecular genetic approach to diagnosis by Child, A, Comeglio, P, Arno, G, Beighton, P

Get full text

Tissue factor reduction and tissue factor pathway inhibitor release after heparin administration by Gori, A M, Pepe, G, Attanasio, M, Falciani, M, Abbate, R, Prisco, D, Fedi, S, Giusti, B, Brunelli, T, Comeglio, P, Gensini, G F, Neri Serneri, G G

“…Elevated plasma levels of tissue factor (TF) and tissue factor pathway inhibitor (TFPI) and large amounts of monocyte procoagulant activity (PCA) have been…”
Get more information

The −174G C interleukin-6 promoter polymorphism influences the development of macular oedema following uncomplicated phacoemulsification surgery by MASOOD, I, NEGI, A, VERNON, S. A, COMEGLIO, P, CHILD, A. H

“…To determine whether the functional -174 G/C interleukin-6 gene polymorphism is a risk factor for the development of cystoid macular oedema (CMO) following…”
Get full text

Fibrillin-1 (FBN1) gene frameshift mutations in Marfan patients: genotype-phenotype correlation by Pepe, G, Giusti, B, Evangelisti, L, Porciani, MC, Brunelli, T, Giurlani, L, Attanasio, M, Fattori, R, Bagni, C, Comeglio, P, Abbate, R, Gensini, GF

“…Marfan syndrome (MFS) is a multisystemic disease associated with mutations in the fibrillin‐1 gene. Most of the reported mutations are missense substitutions…”
Get full text