Search Results - "Combs, Michael P."

Lung microbiota predict chronic rejection in healthy lung transplant recipients: a prospective cohort study by Combs, Michael P, Wheeler, David S, Luth, Jenna E, Falkowski, Nicole R, Walker, Natalie M, Erb-Downward, John R, Lama, Vibha N, Dickson, Robert P

“…Alterations in the respiratory microbiome are common in chronic lung diseases, correlate with decreased lung function, and have been associated with disease…”
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Once-per-day tacrolimus to reduce chronic lung transplant rejection by Combs, Michael P

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Humoral immune responses mediate the development of a restrictive phenotype of chronic lung allograft dysfunction by Misumi, Keizo, Wheeler, David S, Aoki, Yoshiro, Combs, Michael P, Braeuer, Russell R, Higashikubo, Ryuji, Li, Wenjun, Kreisel, Daniel, Vittal, Ragini, Myers, Jeffrey, Lagstein, Amir, Walker, Natalie M, Farver, Carol F, Lama, Vibha N

“…Understanding the distinct pathogenic mechanisms that culminate in allograft fibrosis and chronic graft failure is key in improving outcomes after solid organ…”
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Substituted Judgment in Principle and Practice: A National Physician Survey by Combs, Michael P., MD, Rasinski, Kenneth A., PhD, Yoon, John D., MD, Curlin, Farr A., MD

“…Abstract Objective To describe the extent to which US physicians endorse substituted judgments in principle or accommodate them in practice. Patients and…”
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Turning the Lungs Inside Out: The Intersecting Microbiomes of the Lungs and the Built Environment by Combs, Michael P, Dickson, Robert P

“…Ignore the protestations of our colleagues in gastroenterology: when it comes to surface area, the lungs beat the gut. While out-of-date textbooks claim that…”
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Interleukin 6 trans‐signaling is a critical driver of lung allograft fibrosis by Wheeler, David S., Misumi, Keizo, Walker, Natalie M., Vittal, Ragini, Combs, Michael P., Aoki, Yoshiro, Braeuer, Russell R., Lama, Vibha N.

“…Histopathologic examination of lungs afflicted by chronic lung allograft dysfunction (CLAD) consistently shows both mononuclear cell (MNC) inflammation and…”
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Impact of tacrolimus vs cyclosporine on chronic lung allograft dysfunction incidence and allograft survival in the International Society of Heart and Lung Transplantation registry by Combs, Michael P., Walter, Krysta, Hixson, Haley, Belloli, Elizabeth A., Najor, Matthew S., Chan, Kevin M., Chang, Andrew C., Lyu, Dennis M.

“…The ScanCLAD study reported a lower incidence of chronic lung allograft dysfunction (CLAD) with the use of once-daily tacrolimus vs twice-daily cyclosporine…”
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Results from randomized trial of pirfenidone in patients with chronic rejection (STOP-CLAD study) by Combs, Michael P., Belloli, Elizabeth A., Gargurevich, Nicolas, Flaherty, Kevin R., Murray, Susan, Galbán, Craig J., Lama, Vibha N.

“…Chronic lung allograft dysfunction (CLAD) is the leading long-term cause of poor outcomes after transplant and manifests by fibrotic remodeling of small…”
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A 30-Year-Old Immune Deficient Woman With Persistent Cough and Shortness of Breath by Fels Elliott, Daffolyn Rachael, Combs, Michael P., Attili, Anil K., Farver, Carol F.

“…A 30-year-old woman was referred with increasing shortness of breath and cough in the setting of GATA2 deficiency. She initially presented 9 years previously…”
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Radiographic Graft Surveillance in Lung Transplantation: Prognostic Role of Parametric Response Mapping by Belloli, Elizabeth A., Gu, Tian, Wang, Yizhuo, Vummidi, Dharshan, Lyu, Dennis M., Combs, Michael P., Chughtai, Aamer, Murray, Susan, Galbán, Craig J., Lama, Vibha N.

“…Belloli et al discuss their study on radiographic graft surveillance in lung transplantation. Chronic lung allograft dysfunction (CLAD) results in significant…”
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The Lung Microbiome Predicts Mortality and Response to Azithromycin in Lung Transplant Recipients with Chronic Rejection by Combs, Michael P, Luth, Jenna E, Falkowski, Nicole R, Wheeler, David S, Walker, Natalie M, Erb-Downward, John R, Wakeam, Elliot, Sjoding, Michael W, Dunlap, Daniel G, Admon, Andrew J, Dickson, Robert P, Lama, Vibha N

“…Chronic lung allograft dysfunction (CLAD) is the leading cause of death after lung transplant, and azithromycin has variable efficacy in CLAD. The lung…”
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Genetic deficiency of the transcription factor NFAT1 confers protection against fibrogenic responses independent of immune influx by Vittal, Ragini, Walker, Natalie M, McLinden, A Patrick, Braeuer, Russell R, Ke, Fang, Fattahi, Fatemeh, Combs, Michael P, Misumi, Keizo, Aoki, Yoshiro, Wheeler, David S, Wilke, Carol A, Huang, Steven K, Moore, Bethany B, Cao, Pengxiu, Lama, Vibha N

“…Idiopathic pulmonary fibrosis (IPF) is marked by unremitting matrix deposition and architectural distortion. Multiple profibrotic pathways contribute to the…”
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A multidimensional classifier to support lung transplant referral in patients with pulmonary fibrosis by Pugashetti, Janelle Vu, Kim, John S., Combs, Michael P., Ma, Shwu-Fan, Adegunsoye, Ayodeji, Linderholm, Angela L., Strek, Mary E., Chen, Ching-Hsien, Dilling, Daniel F., Whelan, Timothy P.M., Flaherty, Kevin R., Martinez, Fernando J., Noth, Imre, Oldham, Justin M.

“…Lung transplantation remains the sole curative option for patients with idiopathic pulmonary fibrosis (IPF), but donor organs remain scarce, and many eligible…”
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The association of sleep quality, delirium, and sedation status with daily participation in physical therapy in the ICU by Kamdar, Biren B, Combs, Michael P, Colantuoni, Elizabeth, King, Lauren M, Niessen, Timothy, Neufeld, Karin J, Collop, Nancy A, Needham, Dale M

“…Poor sleep is common in the ICU setting and may represent a modifiable risk factor for patient participation in ICU-based physical therapy (PT) interventions…”
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The mitigating effect of exogenous carbon monoxide on chronic allograft rejection and fibrosis post-lung transplantation by Aoki, Yoshiro, Walker, Natalie M., Misumi, Keizo, Mimura, Takeshi, Vittal, Ragini, McLinden, Aidan P., Fitzgerald, Linda, Combs, Michael P., Lyu, Dennis, Osterholzer, John J., Pinsky, David J., Lama, Vibha N.

“…Small airway inflammation and fibrosis or bronchiolitis obliterans (BO) is the predominant presentation of chronic lung allograft dysfunction (CLAD) post-lung…”
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Fibroproliferation in chronic lung allograft dysfunction: Association of mesenchymal cells in bronchoalveolar lavage with phenotypes and survival by Combs, Michael P., Xia, Meng, Wheeler, David S., Belloli, Elizabeth A., Walker, Natalie M., Braeuer, Russell R., Lyu, Dennis M., Murray, Susan, Lama, Vibha N.

“…Chronic lung allograft dysfunction (CLAD), the primary cause of poor outcome after lung transplantation, arises from fibrotic remodeling of the allograft and…”
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Pretransplant Antifibrotic Therapy Is Associated with Resolution of Primary Graft Dysfunction by Combs, Michael P, Fitzgerald, Linda J, Wakeam, Elliot, Lyu, Dennis M, O'Dwyer, David N

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Conscientious refusals to refer: findings from a national physician survey by Combs, Michael P, Antiel, Ryan M, Tilburt, Jon C, Mueller, Paul S, Curlin, Farr A

“…BackgroundRegarding controversial medical services, many have argued that if physicians cannot in good conscience provide a legal medical intervention for…”
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Impact of Tacrolimus vs. Cyclosporine on CLAD Incidence and Allograft Survival in the ISHLT Registry by Combs, Michael P, Walter, Krysta, Hixson, Haley, Belloli, Elizabeth A, Najor, Matthew S, Chan, Kevin M, Chang, Andrew C, Lyu, Dennis M

“…The ScanCLAD study reported a lower incidence of CLAD with the use of once-daily tacrolimus vs. twice-daily cyclosporine. Using the ISHLT Thoracic Organ…”
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