Search Results - "Combs, D W"

γ-Aminobutyrate-A Receptor Modulation by 3-Aryl-1-(arylsulfonyl)- 1,4,5,6-tetrahydropyridazines by Rybczynski, Philip J, Combs, Donald W, Jacobs, Kimberly, Shank, Richard P, Dubinsky, Barry

“…A series of 3-aryl-1-(arylsulfonyl)-1,4,5,6-tetrahydropyridazine allosteric modulators of the GABAA receptor was synthesized, and biological activity was…”
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6-Benzoxazinylpyridazin-3-ones: potent, long-acting positive inotrope and peripheral vasodilator agents by Combs, Donald W, Rampulla, Marianne S, Bell, Stanley C, Klaubert, Dieter H, Tobia, Alfonso J, Falotico, Robert, Haertlein, Barbara, Lakas-Weiss, Constance, Moore, John B

“…A series of 6-benzoxazinylpyridazin-3-ones was prepared and evaluated for inhibition of cardiac phosphodiesterase (PDE) fraction III in vitro and for positive…”
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Bemoradan--a novel inhibitor of the rolipram-insensitive cyclic AMP phosphodiesterase from canine heart tissue by Moore, Jr, J B, Combs, D W, Tobia, A J

“…Canine cardiac muscle contains a type IV cyclic AMP (cAMP) phosphodiesterase (PDE) that is composed of two subtypes. One subtype is sensitive to rolipram…”
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Nonsteroidal progesterone receptor ligands. 1. 3-Aryl-1-benzoyl-1,4,5,6- tetrahydropyridazines by Combs, Donald W, Reese, Kimberly, Phillips, Audrey

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Nonsteroidal progesterone receptor ligands with unprecedented receptor selectivity by Palmer, Stephen, Campen, Carolyn A, Allan, George F, Rybczynski, Philip, Haynes-Johnson, Donna, Hutchins, Amy, Kraft, Patricia, Kiddoe, Margaret, Lai, Muh-Tsann, Lombardi, Elizabeth, Pedersen, Phyllis, Hodgen, Gary, Combs, Donald W

“…We have characterized a series of nonsteroidal progesterone receptor ligands, the tetrahydropyridazines. Compounds in this series, exemplified by RWJ 26819,…”
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Determination of Hg and other trace elements in soil using neutron activation analysis by ROBINSON, L, DYER, F. F, COMBS, D. W, WADE, J. W, TEASLEY, N. A, CARLTON, J. E, ONDRACEK, A. L, STOKELY, J. R

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Synthesis and cardiotonic activity of a series of substituted 4-alkyl-2(1H)-quinazolinones by Bandurco, Victor T, Schwender, Charles F, Bell, Stanley C, Combs, Donald W, Kanojia, Ramesh M, Levine, Seymour D, Mulvey, Dennis M, Appollina, Mary A, Reed, Marianne S

“…The synthesis, cardiac fraction III cyclic nucleotide phosphodiesterase (PDE-III) inhibition, and positive inotropic activity of a series of…”
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Parallel synthesis of 2-alkoxy and 2-acyloxyphenylpropyl amides and amines using dihydrocoumarins as versatile synthons. Application of a novel resin quench-capture method by Bussolari, Jacqueline C., Rehborn, Diana C., Combs, Donald W.

“…A solution phase synthesis for the preparation of libraries of 2-substituted phenylpropyl amines and amides was accomplished using dihydrocoumarins as a useful…”
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Nonsteroidal Progesterone Receptor Ligands. 2. High-Affinity Ligands with Selectivity for Bone Cell Progesterone Receptors by Combs, Donald W, Reese, Kimberly, Cornelius, Lyndon A. M, Gunnet, Joseph W, Cryan, Ellen V, Granger, Kay S, Jordan, Jerold J, Demarest, Keith T

“…A novel series of nonsteroidal heterocycles was discovered which display cell-type selective, high-affinity (nanomolar) binding to the progesterone receptors…”
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Induction of a novel conformation in the progesterone receptor by ZK299 involves a defined region of the carboxyl-terminal tail by Allan, G F, Lombardi, E, Haynes-Johnson, D, Palmer, S, Kiddoe, M, Kraft, P, Campen, C, Rybczynski, P, Combs, D W, Phillips, A

“…Progesterone receptor antagonists are a promising class of therapeutic drugs indicated for the treatment of a variety of reproductive conditions. Understanding…”
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Design, synthesis and bronchodilatory activity of a series of quinazoline-3-oxides by Combs, D W, Rampulla, M S, Russell, R K, Rampulla, R A, Klaubert, D H, Ritchie, D, Meeks, A S, Kirchner, T

“…A synthetic program of rational drug design was undertaken to develop a series of quinazoline-3-oxides as pulmonary-selective inhibitors of ovalbumin-induced,…”
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Heteroatom analogs of bemoradan: chemistry and cardiotonic activity of 1,4-benzothiazinylpyridazinones by Combs, Donald W, Rampulla, Marianne S, Demers, James P, Falotico, Robert, Moore, John B

“…A series of close analogues of the potent, long-acting cardiotonic bemoradan (2a) was synthesized and examined in both in vitro and in vivo test systems…”
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2,6-Dihydroxy-4H-pyridazino[3,4,5-de]quinazoline: A new ring system by Combs, Donald W., Rampulla, Marianne S.

“…The synthesis and spectral properties of 2,6‐dihydroxy‐4H‐pyridazino[3,4,5‐de]quinazoline 1 are described. This compound represents the first member of a new…”
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Benzoxazinones as PPARγ Agonists. 2. SAR of the Amide Substituent and In Vivo Results in a Type 2 Diabetes Model by Rybczynski, Philip J, Zeck, Roxanne E, Dudash, Joseph, Combs, Donald W, Burris, Thomas P, Yang, Maria, Osborne, Melville C, Chen, Xiaoli, Demarest, Keith T

“…A series of benzoxazinones has been synthesized and tested for PPARγ agonist activity. Synthetic approaches were developed to provide either racemic or chiral…”
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Nonsteroidal progesterone receptor ligands. I: 3-Aryl-1-benzoyl-1,4,5,6-tetrahydropyridazines by COMBS, D. W, REESE, K, PHILLIPS, A

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Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase by Weinstein, David S., Liu, Wen, Gu, Zhengxiang, Langevine, Charles, Ngu, Khehyong, Fadnis, Leena, Combs, Donald W., Sitkoff, Doree, Ahmad, Saleem, Zhuang, Shaobin, Chen, Xing, Wang, Feng-Lai, Loughney, Deborah A., Atwal, Karnail S., Zahler, Robert, Macor, John E., Madsen, Cort S., Murugesan, Natesan

“…[Display omitted] A series of inhibitors of mammalian 15-lipoxygenase based on tryptamine and homotryptamine scaffolds is described. Compounds with aryl…”
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Induction of a novel conformation in the progesterone receptor by ZK299 involves a defined region of the carboxyl-terminal tail by Allan, G F, Lombardi, E, Haynes-Johnson, D, Palmer, S, Kiddoe, M, Kraft, P, Campen, C, Rybczynski, P, Combs, D W, Phillips, A

“…Abstract Progesterone receptor antagonists are a promising class of therapeutic drugs indicated for the treatment of a variety of reproductive conditions…”
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Synthesis and evaluation of spirobenzazepines as potent vasopressin receptor antagonists by Xiang, Min Amy, Chen, Robert H., Demarest, Keith T., Gunnet, Joseph, Look, Richard, Hageman, William, Murray, William V., Combs, Donald W., Patel, Mona

“…Spirobenzazepines as V 1a selective as well as V 1a/V 2 dual vasopressin receptor antagonists have been described. A novel series of spirobenzazepines was…”
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Benzoxazinones as PPARγ agonists. part 1: SAR of three aromatic regions by Rybczynski, Philip J., Zeck, Roxanne E., Combs, Donald W., Turchi, Ignatius, Burris, Thomas P., Xu, Jun Z., Yang, Maria, Demarest, Keith T.

“…A series of benzoxazinones was synthesized as PPARγ agonists. The compounds were obtained in seven steps, and SAR was developed by variations to the core shown…”
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Aminoimidazoles as bioisosteres of acylguanidines: novel, potent, selective and orally bioavailable inhibitors of the sodium hydrogen exchanger isoform-1 by Ahmad, Saleem, Ngu, Khehyong, Combs, Donald W, Wu, Shung C, Weinstein, David S, Liu, Wen, Chen, Bang-Chi, Chandrasena, Gamini, Dorso, Charles R, Kirby, Mark, Atwal, Karnail S

“…Inhibition of the sodium hydrogen exchanger isoform-1 (NHE-1) has been shown to limit damage to the myocardium under ischemic conditions in animals. While most…”
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