Search Results - "Combs, C. K."

Amyloid precursor protein cross‐linking stimulates beta amyloid production and pro‐inflammatory cytokine release in monocytic lineage cells by Sondag, C. M., Combs, C. K.

“…Beta amyloid peptide‐containing neuritic plaques are a defining feature of Alzheimer's disease pathology. Beta amyloid are 38–43 residue peptides derived by…”
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Microglial phenotype is regulated by activity of the transcription factor, NFAT (nuclear factor of activated T cells) by Nagamoto-Combs, Kumi, Combs, Colin K

“…The transcription factor family, nuclear factor of activated T cells (NFAT), regulates immune cell phenotype. Four different calcium/calmodulin-regulated…”
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Microglia repetitively isolated from in vitro mixed glial cultures retain their initial phenotype by Floden, A.M., Combs, C.K.

“…In vitro culture of rodent microglia is a common system used to model proinflammatory changes in the brain. However, typical postnatal brain isolation…”
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APP Regulates Microglial Phenotype in a Mouse Model of Alzheimer's Disease by Manocha, G. D., Floden, A. M., Rausch, K., Kulas, J. A., McGregor, B. A., Rojanathammanee, L., Puig, K. R., Puig, K. L., Karki, S., Nichols, M. R., Darland, D. C., Porter, J. E., Combs, C. K.

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β-Amyloid Stimulation of Microglia and Monocytes Results in TNFα-Dependent Expression of Inducible Nitric Oxide Synthase and Neuronal Apoptosis by Combs, Colin K., Karlo, J. Colleen, Kao, Shih-Chu, Landreth, Gary E.

“…Reactive microglia associated with the β-amyloid plaques in Alzheimer's disease (AD) brains initiate a sequence of inflammatory events integral to the disease…”
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Inflammatory Mechanisms in Alzheimer's Disease: Inhibition of β-Amyloid-Stimulated Proinflammatory Responses and Neurotoxicity by PPARγ Agonists by Combs, Colin K., Johnson, Derrick E., Karlo, J. Colleen, Cannady, Steven B., Landreth, Gary E.

“…Alzheimer's disease (AD) is characterized by the extracellular deposition of β-amyloid fibrils within the brain and the subsequent association and phenotypic…”
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Cellular and Molecular Mechanisms of Glial Scarring and Progressive Cavitation: In Vivo and In Vitro Analysis of Inflammation-Induced Secondary Injury after CNS Trauma by Fitch, Michael T, Doller, Catherine, Combs, Colin K, Landreth, Gary E, Silver, Jerry

“…Post-traumatic cystic cavitation, in which the size and severity of a CNS injury progress from a small area of direct trauma to a greatly enlarged secondary…”
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Low Initial Tau Phosphorylation in Human Brain Biopsy Samples by Song, J, Combs, C.K, Pilcher, W.H, Song, L.Y, Utal, A.K, Coleman, P.D

“…A rapid reversible tau phosphorylation at Ser 396/404 was observed in adult human cortical biopsy tissue and rat primary cortical cell cultures. Tau…”
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Identification of Microglial Signal Transduction Pathways Mediating a Neurotoxic Response to Amyloidogenic Fragments of beta -Amyloid and Prion Proteins by Combs, Colin K, Johnson, Derrick E, Cannady, Steve B, Lehman, Timothy M, Landreth, Gary E

“…Microglial interaction with amyloid fibrils in the brains of Alzheimer's and prion disease patients results in the inflammatory activation of these cells. We…”
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beta -Amyloid Fibrils Activate Parallel Mitogen-Activated Protein Kinase Pathways in Microglia and THP1 Monocytes by McDonald, Douglas R, Bamberger, Maria E, Combs, Colin K, Landreth, Gary E

“…The senile plaques of Alzheimer's disease are foci of local inflammatory responses, as evidenced by the presence of acute phase proteins and oxidative damage…”
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Amyloid Precursor Protein Mediates Proinflammatory Activation of Monocytic Lineage Cells by Sondag, Cindy M, Combs, Colin K

“…Alzheimer's disease is a progressive neurodegenerative disorder characterized by extracellular deposition of β-amyloid (Aβ) peptide containing neuritic…”
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Regulation of β-amyloid stimulated proinflammatory responses by peroxisome proliferator-activated receptor α by Combs, Colin K, Bates, Patricia, Karlo, J.Colleen, Landreth, Gary E

“…Amyloid deposition within the brains of Alzheimer's Disease patients results in the activation of microglial cells and the induction of a local inflammatory…”
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Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors by Floden, Angela M, Li, Shanshan, Combs, Colin K

“…Although abundant reactive microglia are found associated with beta-amyloid (Abeta) plaques in Alzheimer's disease (AD) brains, their contribution to cell loss…”
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beta-Amyloid Stimulates Murine Postnatal and Adult Microglia Cultures in a Unique Manner by Floden, Angela M, Combs, Colin K

“…Reactive microglia are commonly observed in association with the beta-amyloid (Abeta) plaques of Alzheimer's disease brains. This localization supports the…”
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Developmental regulation and PKC dependence of Alzheimer's-type tau phosphorylations in cultured fetal rat hippocampal neurons by Combs, Colin K, Coleman, Paul D, O'Banion, M.Kerry

“…Attempts to describe a mechanism of neurofibrillary tangle formation often focus on site specific phosphorylations of tau protein. These have typically been…”
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Inflammatory Mechanisms in Alzheimer's Disease: Inhibition of beta -Amyloid-Stimulated Proinflammatory Responses and Neurotoxicity by PPARgamma Agonists by Combs, Colin K, Johnson, Derrick E, Karlo, J. Colleen, Cannady, Steven B, Landreth, Gary E

“…Alzheimer's disease (AD) is characterized by the extracellular deposition of beta-amyloid fibrils within the brain and the subsequent association and…”
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beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis by Combs, C K, Karlo, J C, Kao, S C, Landreth, G E

“…Reactive microglia associated with the beta-amyloid plaques in Alzheimer's disease (AD) brains initiate a sequence of inflammatory events integral to the…”
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