Search Results - "Combrié, Robert"

Severe deficiency of glycoprotein VI in a patient with gray platelet syndrome by Nurden, Paquita, Jandrot-Perrus, Martine, Combrié, Robert, Winckler, Joelle, Arocas, Veronique, Lecut, Christelle, Pasquet, Jean-Max, Kunicki, Thomas J., Nurden, Alan T.

“…We report a novel case of gray platelet syndrome (GPS) where a severe deficiency of the platelet collagen receptor, glycoprotein (GP) VI, accompanies classical…”
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Immunolocalization of P2Y1 and TPα receptors in platelets showed a major pool associated with the membranes of α-granules and the open canalicular system by Nurden, Paquita, Poujol, Christel, Winckler, Joelle, Combrié, Robert, Pousseau, Nathalie, Conley, Pamela B., Levy-Toledano, Sylviane, Habib, Aida, Nurden, Alan T.

“…P2Y1 and thromboxane-prostanoid–α (TPα) receptors on platelets belong to the G-protein–coupled 7–transmembrane domain family. They transmit signals for shape…”
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Detection of transfused platelets in a patient with Glanzmann thrombasthenia by Nurden, Alan, Combrié, Robert, Nurden, Paquita

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Labeling of the internal pool of GP IIb-IIIa in platelets by c7E3 Fab fragments (abciximab) : Flow and endocytic mechanisms contribute to the transport by NURDEN, P, POUJOL, C, DURRIEU-JAIS, C, WINCKLER, J, COMBRIE, R, MACCHI, L, BIHOUR, C, WAGNER, C, JORDAN, R, NURDEN, A. T

“…Abciximab is a new antiplatelet therapeutic in ischemic cardiovascular disease. The drug, chimeric Fab fragments of a murine monoclonal antibody (MoAb) (c7E3),…”
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A Ser752→Pro substitution in the cytoplasmic domain of β3 in a Glanzmann thrombasthenia variant fails to prevent interactions between the αIIbβ3 integrin and the platelet granule pool of fibrinogen by Nurden, Paquita, Poujol, Christel, Winckler, Joelle, Combrié, Robert, Caen, Jacques P., Nurden, Alan T.

“…A Glanzmann thrombasthenia variant with a β3 Ser752→Pro cytoplasmic domain substitution has platelets that fail to aggregate or bind soluble fibrinogen (Fg)…”
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Phenotypic heterogeneity in the Gray platelet syndrome extends to the expression of TREM family member, TLT-1 by Nurden, Alan T, Nurden, Paquita, Bermejo, Emilsé, Combrié, Robert, McVicar, Daniel W, Washington, A Valance

“…The Gray platelet syndrome (GPS) is a rare inherited disorder linked to undefined molecular abnormalities that prevent the formation and maturation of…”
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Paradoxical platelet activation was not observed on dissociation of abciximab from GpIIb-IIIa complexes by Ndoko, Serge, Poujol, Christel, Combrié, Robert, Nurden, Alan, Nurden, Paquita

“…The ability of abciximab to bind and dissociate from platelets raises the question of the conformational state of GPIIb-IIIa complexes losing abciximab and the…”
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Heterozygotes in the bernard–soulier syndrome do not necessarily have giant platelets or thrombocytopenia by Nurden, Alan T, Combrié, Robert, Claeyssens, Ségolène, Nurden, Paquita

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A Novel Missense Mutation Shows that GPIbβ Has a Dual Role in Controlling the Processing and Stability of the Platelet GPIb-IX Adhesion Receptor by Strassel, Catherine, Pasquet, Jean-Max, Alessi, Marie-Christine, Juhan-Vague, Irène, Chambost, Hervé, Combrié, Robert, Nurden, Paquita, Bas, Marie-Jeanne, De La Salle, Corinne, Cazenave, Jean-Pierre, Lanza, François, Nurden, Alan T

“…Glycoprotein (GP) Ibα is a major adhesive receptor of platelets, surface expressed as part of the GPIb-IX-V complex. However, important questions about how the…”
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A novel hemizygous Bernard-Soulier Syndrome (BSS) mutation in the amino terminal domain of glycoprotein (GP)Ibbeta--platelet characterization and transfection studies by Hillmann, Andrew, Nurden, Alan, Nurden, Paquita, Combrié, Robert, Claeyssens, Ségolène, Moran, Niamh, Kenny, Dermot

“…Glycoprotein (GP) Ib-V-IX is a unique adhesion receptor complex on platelets. Mutations in GPIbalpha, Ibbeta, and IX can lead to the rare bleeding disorder,…”
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Labeling of the Internal Pool of GP IIb-IIIa in Platelets by c7E3 Fab Fragments (abciximab): Flow and Endocytic Mechanisms Contribute to the Transport by Nurden, Paquita, Poujol, Christel, Durrieu-Jais, Catherine, Winckler, Joëlle, Combrié, Robert, Macchi, Laurent, Bihour, Claude, Wagner, Carrie, Jordan, Robert, Nurden, Alan T.

“…Abciximab is a new antiplatelet therapeutic in ischemic cardiovascular disease. The drug, chimeric Fab fragments of a murine monoclonal antibody (MoAb) (c7E3),…”
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Analysis of the amino acid requirement for a normal alphaIIbbeta3 maturation at alphaIIbGlu324 commonly mutated in Glanzmann thrombasthenia by Milet-Marsal, Sandrine, Breillat, Christelle, Peyruchaud, Olivier, Nurden, Paquita, Combrié, Robert, Nurden, Alan T, Bourre, François

“…Glanzmann thrombasthenia is an inherited bleeding disorder arising from quantitative or qualitative defects of the alphaIIbbeta3 integrin of platelets. Here,…”
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A Ser 752 →Pro substitution in the cytoplasmic domain of β3 in a Glanzmann thrombasthenia variant fails to prevent interactions between the αIIbβ3 integrin and the platelet granule pool of fibrinogen by Nurden, Paquita, Poujol, Christel, Winckler, Joelle, Combrié, Robert, Caen, Jacques P., Nurden, Alan T.

“…A Glanzmann thrombasthenia variant with a β3 Ser 752 →Pro cytoplasmic domain substitution has platelets that fail to aggregate or bind soluble fibrinogen (Fg)…”
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A Ser752-->Pro substitution in the cytoplasmic domain of beta3 in a Glanzmann thrombasthenia variant fails to prevent interactions between the alphaIIbbeta3 integrin and the platelet granule pool of fibrinogen by Nurden, Paquita, Poujol, Christel, Winckler, Joelle, Combrié, Robert, Caen, Jacques P, Nurden, Alan T

“…A Glanzmann thrombasthenia variant with a beta3 Ser752-->Pro cytoplasmic domain substitution has platelets that fail to aggregate or bind soluble fibrinogen…”
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Impaired megakaryocytopoiesis in type 2B von Willebrand disease with severe thrombocytopenia by Nurden, Paquita, Debili, Najet, Vainchenker, William, Bobe, Regis, Bredoux, Raymonde, Corvazier, Elisabeth, Combrie, Robert, Fressinaud, Edith, Meyer, Dominique, Nurden, Alan T., Enouf, Jocelyne

“…In type 2B von Willebrand disease, there is spontaneous binding of mutated von Willebrand factor (VWF) multimers to platelets. Here we report a family in which…”
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Reduced collagen-induced platelet aggregation in obligate heterozygotes of a Glanzmann thrombasthenia variant with a beta 3 mutation by Nurden, Alan, Jacquelin, Béatrice, Tuleja, Ewa, Combrié, Robert, Nurden, Paquita

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Immunolocalization of P2Y1 and TPalpha receptors in platelets showed a major pool associated with the membranes of alpha -granules and the open canalicular system by Nurden, Paquita, Poujol, Christel, Winckler, Joelle, Combrié, Robert, Pousseau, Nathalie, Conley, Pamela B, Levy-Toledano, Sylviane, Habib, Aida, Nurden, Alan T

“…P2Y(1) and thromboxane-prostanoid-alpha (TPalpha) receptors on platelets belong to the G-protein-coupled 7-transmembrane domain family. They transmit signals…”
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Autoimmune thrombocytopenic purpura (AITP) and acquired thrombasthenia due to autoantibodies to GP IIb–IIIa in a patient with an unusual platelet membrane glycoprotein composition by Macchi, Laurent, Nurden, Paquita, Marit, Gérald, Bihour, Claude, Clofent‐Sanchez, Gisèle, Combrié, Robert, Nurden, Alan T.

“…The subject (E.B.) is a 63‐year‐old woman with autoimmune thrombocytopenic purpura (AITP) who was first examined some 6 years ago with symptoms of epistaxis…”
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Thrombin Induces a Rapid Redistribution of Glycoprotein Ib-IX Complexes Within the Membrane Systems of Activated Human Platelets by Hourdillé, Paquita, Heilmann, Eric, Combrié, Robert, Winckler, Joëlle, Clemetson, Kenneth J., Nurden, Alan T.

“…Previous studies have shown a decreased binding of mono-clonal antibodies (MoAbs) to glycoprotein (GP) Ib-IX complexes on thrombin-stimulated platelets, but…”
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A novel missense mutation shows that GPIbbeta has a dual role in controlling the processing and stability of the platelet GPIb-IX adhesion receptor by Strassel, Catherine, Pasquet, Jean-Max, Alessi, Marie-Christine, Juhan-Vague, Irène, Chambost, Hervé, Combrié, Robert, Nurden, Paquita, Bas, Marie-Jeanne, De La Salle, Corinne, Cazenave, Jean-Pierre, Lanza, François, Nurden, Alan T

“…Glycoprotein (GP) Ibalpha is a major adhesive receptor of platelets, surface expressed as part of the GPIb-IX-V complex. However, important questions about how…”
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