Search Results - "Combes, Sebastien"

CRCM5484: A BET-BDII Selective Compound with Differential Anti-leukemic Drug Modulation by Carrasco, Kendall, Montersino, Camille, Derviaux, Carine, Saez-Ayala, Magali, Hoffer, Laurent, Restouin, Audrey, Castellano, Rémy, Casassa, Justine, Roche, Philippe, Pasquier, Eddy, Combes, Sébastien, Morelli, Xavier, Collette, Yves, Betzi, Stéphane

“…Differentially screening the Fr-PPIChem chemical library on the bromodomain and extra-terminal (BET) BRD4-BDII versus -BDI bromodomains led to the discovery of…”
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Triangular Regulation of Cucurbit[8]uril 1:1 Complexes by Combes, Sébastien, Tran, Khoa Truong, Ayhan, Mehmet Menaf, Karoui, Hakim, Rockenbauer, Antal, Tonetto, Alain, Monnier, Valérie, Charles, Laurence, Rosas, Roselyne, Viel, Stéphane, Siri, Didier, Tordo, Paul, Clair, Sylvain, Wang, Ruibing, Bardelang, David, Ouari, Olivier

“…Triangular shapes have inspired scientists over time and are common in nature, such as the flower petals of oxalis triangularis, the triangular faces of…”
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New Ianthelliformisamine Derivatives as Antibiotic Enhancers against Resistant Gram-Negative Bacteria by Pieri, Cyril, Borselli, Diane, Di Giorgio, Carole, De Méo, Michel, Bolla, Jean-Michel, Vidal, Nicolas, Combes, Sébastien, Brunel, Jean Michel

“…A series consisting of ianthelliformisamimes A, B, and C as well as its synthetic analogues was prepared in high chemical yield, from 27 to 91%, using peptide…”
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Synthesis and Biological Evaluation of 4-Arylcoumarin Analogues of Combretastatins. Part 2 by Combes, Sébastien, Barbier, Pascale, Douillard, Soazig, McLeer-Florin, Anne, Bourgarel-Rey, Véronique, Pierson, Jean-Thomas, Fedorov, Alexey Yu, Finet, Jean-Pierre, Boutonnat, Jean, Peyrot, Vincent

“…A series of A-ring variously methoxylated 4-(3-hydroxy-4-methoxyphenyl)coumarins related to combretastatin A-4 was prepared by cross-coupling reactions…”
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First evidence for the use of polyamines as nucleophiles in a regioselective palladium-catalyzed allylic amination reaction by Pieri, Cyril, Combes, Sébastien, Brunel, Jean Michel

“…Palladium-catalyzed reaction of unsymmetrical allylic electrophiles with polyamines gives rise to regioisomeric allylic polyamines. An original catalytic…”
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Synthesis and antiprotozoal activity of 4-arylcoumarins by Pierson, Jean-Thomas, Dumètre, Aurélien, Hutter, Sébastien, Delmas, Florence, Laget, Michèle, Finet, Jean-Pierre, Azas, Nadine, Combes, Sébastien

“…A large series of 4-arylcoumarins was synthesized by Suzuki-Miyaura cross-coupling reaction and evaluated for antiprotozoal activity against Plasmodium…”
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Allocolchicinoids bearing a Michael acceptor fragment for possible irreversible binding of tubulin by Sazanova, Ekaterina S, Gracheva, Iuliia A, Allegro, Diane, Barbier, Pascale, Combes, Sébastien, Svirshchevskaya, Elena V, Fedorov, Alexey Yu

“…We describe an attempt to apply the concept of covalent binding towards the highly active allocolchicinoids selected on the basis of SAR analysis of previously…”
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The indolylcoumarin COUFIN exhibits potent activity against renal carcinoma cells without affecting hematopoietic system by Champelovier, Pierre, Barbier, Pascale, Daras, Etienne, Douillard, Soazig, Toussaint, Bertrand, Persoon, Virginie, Curri, Veronique, Peyrot, Vincent, Combes, Sebastien

“…The present work describes the anticancer activity of a new indolylcoumarin named COUFIN and more specifically, its efficiency against clear cell renal…”
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Synthesis and biological evaluation of polymethoxylated 4-heteroarylcoumarins as tubulin assembly inhibitor by Ganina, Olga G., Daras, Etienne, Bourgarel-Rey, Véronique, Peyrot, Vincent, Andresyuk, Alexey N., Finet, Jean-Pierre, Fedorov, Alexey Yu, Beletskaya, Irina P., Combes, Sébastien

“…A series of syn-restricted polymethoxylated 4-heteroarylcoumarins—the isostuctural analogs of combretastatin A-4—was synthesized by Suzuki–Miyaura…”
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Synthesis and biological evaluation of novel anticancer bivalent colchicine–tubulizine hybrids by Malysheva, Yulia B., Combes, Sebastien, Allegro, Diane, Peyrot, Vincent, Knochel, Paul, Gavryushin, Andrei E., Fedorov, Alexey Yu

“…A series of novel antimitotic hybrids were synthesized in good yields by linking of azide-containing colchicine congeners with acetylene-substituted…”
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Dinitroxides for Solid State Dynamic Nuclear Polarization by Ysacco, Cédric, Karoui, Hakim, Casano, Gilles, Le Moigne, François, Combes, Sébastien, Rockenbauer, Antal, Rosay, Melanie, Maas, Werner, Ouari, Olivier, Tordo, Paul

“…We have prepared a series of dinitroxides and we investigated their properties as polarizing agents for solid-state nuclear magnetic resonance/dynamic nuclear…”
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Interaction of 4-Arylcoumarin Analogues of Combretastatins with Microtubule Network of HBL100 Cells and Binding to Tubulin by Rappl, Catherine, Barbier, Pascale, Bourgarel-Rey, Véronique, Grégoire, Catherine, Gilli, Robert, Carre, Manon, Combes, Sébastien, Finet, Jean-Pierre, Peyrot, Vincent

“…The synthesis of different 4-arylcoumarin analogues of combretastatin A-4 led to the identification of two new compounds (1 and 2) with potent cytotoxic…”
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Tumor selective cytotoxic action of a thiomorpholin hydroxamate inhibitor (TMI-1) in breast cancer by Mezil, Lynda, Berruyer-Pouyet, Carole, Cabaud, Olivier, Josselin, Emmanuelle, Combes, Sébastien, Brunel, Jean-Michel, Viens, Patrice, Collette, Yves, Birnbaum, Daniel, Lopez, Marc

“…Targeted therapies, associated with standard chemotherapies, have improved breast cancer care. However, primary and acquired resistances are frequently…”
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Hot water treatments reduce leaf yellowing and extend vase life of Asiatic hybrid lilies by Woolf, Allan B., Combes, Sébastien, Petley, Mary, Olsson, Shane R., Wohlers, Mark, Jackman, Richard C.

“…► Short duration hot water treatment (HWT) of the leaves of Asiatic lilies can effectively minimise leaf yellowing in stored, and non-stored stems. ► Reduction…”
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4-Arylcoumarin analogues of combretastatins stimulate apoptosis of leukemic cells from chronic lymphocytic leukemia patients by Billard, Christian, Menasria, Faouzia, Quiney, Claire, Faussat, Anne-Marie, Finet, Jean-Pierre, Combes, Sébastien, Kolb, Jean-Pierre

“…Objective To investigate the proapoptotic capacities of four arylcoumarin analogues of combretastatins on leukemic cells from B-cell chronic lymphocytic…”
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Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach by Hoffer, Laurent, Voitovich, Yuliia V, Raux, Brigitt, Carrasco, Kendall, Muller, Christophe, Fedorov, Aleksey Y, Derviaux, Carine, Amouric, Agnès, Betzi, Stéphane, Horvath, Dragos, Varnek, Alexandre, Collette, Yves, Combes, Sébastien, Roche, Philippe, Morelli, Xavier

“…Over the past few decades, hit identification has been greatly facilitated by advances in high-throughput and fragment-based screenings. One major hurdle…”
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Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins by Raux, Brigitt, Voitovich, Yuliia, Derviaux, Carine, Lugari, Adrien, Rebuffet, Etienne, Milhas, Sabine, Priet, Stéphane, Roux, Thomas, Trinquet, Eric, Guillemot, Jean-Claude, Knapp, Stefan, Brunel, Jean-Michel, Fedorov, Alexey Yu, Collette, Yves, Roche, Philippe, Betzi, Stéphane, Combes, Sébastien, Morelli, Xavier

“…A midthroughput screening follow-up program targeting the first bromodomain of the human BRD4 protein, BRD4­(BD1), identified an acetylated-mimic xanthine…”
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Cascade Synthesis of Polyoxygenated 6H,11H-[2]Benzopyrano-[4,3-c][1]benzopyran-11-ones by Naumov, Mikael I, Sutirin, Sergey A, Shavyrin, Andrey S, Ganina, Olga G, Beletskaya, Irina P, Bourgarel-Rey, Véronique, Combes, Sébastien, Finet, Jean-Pierre, Fedorov, Alexey Yu

“…2-(Methoxymethoxymethyl)aryllead triacetates, obtained in situ from the corresponding arylboronic acids, reacted with 4-hydroxycoumarins, leading to…”
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From a drug repositioning to a structure-based drug design approach to tackle acute lymphoblastic leukemia by Saez-Ayala, Magali, Hoffer, Laurent, Abel, Sébastien, Ben Yaala, Khaoula, Sicard, Benoit, Andrieu, Guillaume P., Latiri, Mehdi, Davison, Emma K., Ciufolini, Marco A., Brémond, Paul, Rebuffet, Etienne, Roche, Philippe, Derviaux, Carine, Voisset, Edwige, Montersino, Camille, Castellano, Remy, Collette, Yves, Asnafi, Vahid, Betzi, Stéphane, Dubreuil, Patrice, Combes, Sébastien, Morelli, Xavier

“…Cancer cells utilize the main de novo pathway and the alternative salvage pathway for deoxyribonucleotide biosynthesis to achieve adequate nucleotide pools…”
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A clickable melphalan for monitoring DNA interstrand crosslink accumulation and detecting ICL repair defects in Fanconi anemia patient cells by Berrada, Sara, Martínez-Balsalobre, Elena, Larcher, Lise, Azzoni, Violette, Vasquez, Nadia, Da Costa, Mélanie, Abel, Sébastien, Audoly, Gilles, Lee, Lara, Montersino, Camille, Castellano, Rémy, Combes, Sébastien, Gelot, Camille, Ceccaldi, Raphaël, Guervilly, Jean-Hugues, Soulier, Jean, Lachaud, Christophe

“…Abstract Fanconi anemia (FA) is a genetic disorder associated with developmental defects, bone marrow failure and cancer. The FA pathway is crucial for the…”
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