Search Results - "Combes, N"

Kidney organoids: accurate models or fortunate accidents by Little, Melissa H, Combes, Alexander N

“…There are now many reports of human kidney organoids generated via the directed differentiation of human pluripotent stem cells (PSCs) based on an existing…”
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Single-cell analysis reveals congruence between kidney organoids and human fetal kidney by Combes, Alexander N, Zappia, Luke, Er, Pei Xuan, Oshlack, Alicia, Little, Melissa H

“…Human kidney organoids hold promise for studying development, disease modelling and drug screening. However, the utility of stem cell-derived kidney tissues…”
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Evaluation of variability in human kidney organoids by Phipson, Belinda, Er, Pei X., Combes, Alexander N., Forbes, Thomas A., Howden, Sara E., Zappia, Luke, Yen, Hsan-Jan, Lawlor, Kynan T., Hale, Lorna J., Sun, Jane, Wolvetang, Ernst, Takasato, Minoru, Oshlack, Alicia, Little, Melissa H.

“…The utility of human pluripotent stem cell–derived kidney organoids relies implicitly on the robustness and transferability of the protocol. Here we analyze…”
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Kidney micro-organoids in suspension culture as a scalable source of human pluripotent stem cell-derived kidney cells by Kumar, Santhosh V, Er, Pei X, Lawlor, Kynan T, Motazedian, Ali, Scurr, Michelle, Ghobrial, Irene, Combes, Alexander N, Zappia, Luke, Oshlack, Alicia, Stanley, Edouard G, Little, Melissa H

“…Kidney organoids have potential uses in disease modelling, drug screening and regenerative medicine. However, novel cost-effective techniques are needed to…”
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Global Quantification of Tissue Dynamics in the Developing Mouse Kidney by Short, Kieran M., Combes, Alexander N., Lefevre, James, Ju, Adler L., Georgas, Kylie M., Lamberton, Timothy, Cairncross, Oliver, Rumballe, Bree A., McMahon, Andrew P., Hamilton, Nicholas A., Smyth, Ian M., Little, Melissa H.

“…Although kidneys of equal size can vary 10-fold in nephron number at birth, discovering what regulates such variation has been hampered by a lack of…”
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Luminal Mitosis Drives Epithelial Cell Dispersal within the Branching Ureteric Bud by Packard, Adam, Georgas, Kylie, Michos, Odyssé, Riccio, Paul, Cebrian, Cristina, Combes, Alexander N., Ju, Adler, Ferrer-Vaquer, Anna, Hadjantonakis, Anna-Katerina, Zong, Hui, Little, Melissa H., Costantini, Frank

“…The ureteric bud is an epithelial tube that undergoes branching morphogenesis to form the renal collecting system. Although development of a normal kidney…”
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Nephron formation adopts a novel spatial topology at cessation of nephrogenesis by Rumballe, Bree A., Georgas, Kylie M., Combes, Alexander N., Ju, Adler L., Gilbert, Thierry, Little, Melissa H.

“…Nephron number in the mammalian kidney is known to vary dramatically, with postnatal renal function directly influenced by nephron complement. What determines…”
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Analysis of vapor-liquid-solid mechanism in Au-assisted GaAs nanowire growth by Harmand, J. C., Patriarche, G., Péré-Laperne, N., Mérat-Combes, M-N., Travers, L., Glas, F.

“…GaAs nanowires were grown by molecular-beam epitaxy on (111)B oriented surfaces, after the deposition of Au nanoparticles. Different growth durations and…”
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Hamartin regulates cessation of mouse nephrogenesis independently of Mtor by Volovelsky, Oded, Nguyen, Thi, Jarmas, Alison E., Combes, Alexander N., Wilson, Sean B., Little, Melissa H., Witte, David P., Brunskill, Eric W., Kopan, Raphael

“…Nephrogenesis concludes by the 36th week of gestation in humans and by the third day of postnatal life in mice. Extending the nephrogenic period may reduce the…”
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Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis by Yermalovich, Alena V., Osborne, Jihan K., Sousa, Patricia, Han, Areum, Kinney, Melissa A., Chen, Michael J., Robinton, Daisy A., Montie, Helen, Pearson, Dan S., Wilson, Sean B., Combes, Alexander N., Little, Melissa H., Daley, George Q.

“…In humans and in mice the formation of nephrons during embryonic development reaches completion near the end of gestation, after which no new nephrons are…”
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Cell-Cell Interactions Driving Kidney Morphogenesis by Combes, Alexander N, Davies, Jamie A, Little, Melissa H

“…The mammalian kidney forms via cell-cell interactions between an epithelial outgrowth of the nephric duct and the surrounding nephrogenic mesenchyme. Initial…”
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Endothelial cell migration directs testis cord formation by Combes, Alexander N., Wilhelm, Dagmar, Davidson, Tara, Dejana, Elisabetta, Harley, Vincent, Sinclair, Andrew, Koopman, Peter

“…While the molecular cues initiating testis determination have been identified in mammals, the cellular interactions involved in generating a functional testis…”
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Mortality of French participants in the Tour de France (1947-2012) by Marijon, Eloi, Tafflet, Muriel, Antero-Jacquemin, Juliana, El Helou, Nour, Berthelot, Geoffroy, Celermajer, David S, Bougouin, Wulfran, Combes, Nicolas, Hermine, Olivier, Empana, Jean-Philippe, Rey, Grégoire, Toussaint, Jean-François, Jouven, Xavier

“…In the context of recent concerns regarding performance enhancing techniques and potential negative health effects of high-level physical activity, data on the…”
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Nephron progenitor commitment is a stochastic process influenced by cell migration by Lawlor, Kynan T, Zappia, Luke, Lefevre, James, Park, Joo-Seop, Hamilton, Nicholas A, Oshlack, Alicia, Little, Melissa H, Combes, Alexander N

“…Progenitor self-renewal and differentiation is often regulated by spatially restricted cues within a tissue microenvironment. Here, we examine how progenitor…”
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ROBO2 restricts the nephrogenic field and regulates Wolffian duct–nephrogenic cord separation by Wainwright, Elanor N., Wilhelm, Dagmar, Combes, Alexander N., Little, Melissa H., Koopman, Peter

“…ROBO2 plays a key role in regulating ureteric bud (UB) formation in the embryo, with mutations in humans and mice leading to supernumerary kidneys. Previous…”
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SOX9 Regulates Prostaglandin D Synthase Gene Transcription in Vivo to Ensure Testis Development by Wilhelm, Dagmar, Hiramatsu, Ryuji, Mizusaki, Hirofumi, Widjaja, Laura, Combes, Alexander N., Kanai, Yoshiakira, Koopman, Peter

“…In mammals, male sex is determined by the Y-chromosomal gene Sry (sex-determining region of Y chromosome). The expression of Sry and subsequently Sox9 (SRY box…”
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Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment by Georgas, Kylie, Rumballe, Bree, Valerius, M. Todd, Chiu, Han Sheng, Thiagarajan, Rathi D., Lesieur, Emmanuelle, Aronow, Bruce J., Brunskill, Eric W., Combes, Alexander N., Tang, Dave, Taylor, Darrin, Grimmond, Sean M., Potter, S. Steven, McMahon, Andrew P., Little, Melissa H.

“…While nephron formation is known to be initiated by a mesenchyme-to-epithelial transition of the cap mesenchyme to form a renal vesicle (RV), the subsequent…”
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Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination by Wilhelm, Dagmar, Martinson, Fred, Bradford, Stephen, Wilson, Megan J., Combes, Alexander N., Beverdam, Annemiek, Bowles, Josephine, Mizusaki, Hirofumi, Koopman, Peter

“…We have raised an antibody specifically recognizing endogenous mouse SRY protein and used it to investigate the molecular and cellular mode of action of SRY in…”
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Haploinsufficiency for the Six2 gene increases nephron progenitor proliferation promoting branching and nephron number by Combes, Alexander N, Wilson, Sean, Phipson, Belinda, Binnie, Brandon B, Ju, Adler, Lawlor, Kynan T, Cebrian, Cristina, Walton, Sarah L, Smyth, Ian M, Moritz, Karen M, Kopan, Raphael, Oshlack, Alicia, Little, Melissa H

“…The regulation of final nephron number in the kidney is poorly understood. Cessation of nephron formation occurs when the self-renewing nephron progenitor…”
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An In Vitro Differentiation Protocol for Human Embryonic Bipotential Gonad and Testis Cell Development by Knarston, Ingrid M., Pachernegg, Svenja, Robevska, Gorjana, Ghobrial, Irene, Er, Pei Xuan, Georges, Elizabeth, Takasato, Minoru, Combes, Alexander N., Jørgensen, Anne, Little, Melissa H., Sinclair, Andrew H., Ayers, Katie L.

“…Currently an in vitro model that fully recapitulates the human embryonic gonad is lacking. Here we describe a fully defined feeder-free protocol to generate…”
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