Search Results - "Comaills, Valentine"

Nuclear Envelope Integrity in Health and Disease: Consequences on Genome Instability and Inflammation by Gauthier, Benoit R., Comaills, Valentine

“…The dynamic nature of the nuclear envelope (NE) is often underestimated. The NE protects, regulates, and organizes the eukaryote genome and adapts to…”
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Chromosomal Instability in Genome Evolution: From Cancer to Macroevolution by Comaills, Valentine, Castellano-Pozo, Maikel

“…The integrity of the genome is crucial for the survival of all living organisms. However, genomes need to adapt to survive certain pressures, and for this…”
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Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis by Ebright, Richard Y, Lee, Sooncheol, Wittner, Ben S, Niederhoffer, Kira L, Nicholson, Benjamin T, Bardia, Aditya, Truesdell, Samuel, Wiley, Devon F, Wesley, Benjamin, Li, Selena, Mai, Andy, Aceto, Nicola, Vincent-Jordan, Nicole, Szabolcs, Annamaria, Chirn, Brian, Kreuzer, Johannes, Comaills, Valentine, Kalinich, Mark, Haas, Wilhelm, Ting, David T, Toner, Mehmet, Vasudevan, Shobha, Haber, Daniel A, Maheswaran, Shyamala, Micalizzi, Douglas S

“…Circulating tumor cells (CTCs) are shed into the bloodstream from primary tumors, but only a small subset of these cells generates metastases. We conducted an…”
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ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells by Yazinski, Stephanie A, Comaills, Valentine, Buisson, Rémi, Genois, Marie-Michelle, Nguyen, Hai Dang, Ho, Chu Kwen, Todorova Kwan, Tanya, Morris, Robert, Lauffer, Sam, Nussenzweig, André, Ramaswamy, Sridhar, Benes, Cyril H, Haber, Daniel A, Maheswaran, Shyamala, Birrer, Michael J, Zou, Lee

“…Poly-(ADP-ribose) polymerase (PARP) inhibitors (PARPis) selectively kill BRCA1/2-deficient cells, but their efficacy in BRCA-deficient patients is limited by…”
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Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility by Yu, Min, Bardia, Aditya, Aceto, Nicola, Bersani, Francesca, Madden, Marissa W., Donaldson, Maria C., Desai, Rushil, Zhu, Huili, Comaills, Valentine, Zheng, Zongli, Wittner, Ben S., Stojanov, Petar, Brachtel, Elena, Sgroi, Dennis, Kapur, Ravi, Shioda, Toshihiro, Ting, David T., Ramaswamy, Sridhar, Getz, Gad, Iafrate, A. John, Benes, Cyril, Toner, Mehmet, Maheswaran, Shyamala, Haber, Daniel A.

“…Circulating tumor cells (CTCs) are present at low concentrations in the peripheral blood of patients with solid tumors. It has been proposed that the…”
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A Sox2–Sox9 signalling axis maintains human breast luminal progenitor and breast cancer stem cells by Domenici, Giacomo, Aurrekoetxea-Rodríguez, Iskander, Simões, Bruno M., Rábano, Miriam, Lee, So Young, Millán, Julia San, Comaills, Valentine, Oliemuller, Erik, López-Ruiz, José A., Zabalza, Ignacio, Howard, Beatrice A., Kypta, Robert M., Vivanco, Maria dM

“…Increased cancer stem cell content during development of resistance to tamoxifen in breast cancer is driven by multiple signals, including Sox2-dependent…”
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Sox2 promotes tamoxifen resistance in breast cancer cells by Piva, Marco, Domenici, Giacomo, Iriondo, Oihana, Rábano, Miriam, Simões, Bruno M, Comaills, Valentine, Barredo, Inmaculada, López‐Ruiz, Jose A, Zabalza, Ignacio, Kypta, Robert, Vivanco, Maria d M

“…Development of resistance to therapy continues to be a serious clinical problem in breast cancer management. Cancer stem/progenitor cells have been shown to…”
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Physical Forces and Transient Nuclear Envelope Rupture during Metastasis: The Key for Success? by Gauthier, Benoit R, Lorenzo, Petra I, Comaills, Valentine

“…During metastasis, invading tumor cells and circulating tumor cells (CTC) face multiple mechanical challenges during migration through narrow pores and cell…”
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AR Expression in Breast Cancer CTCs Associates with Bone Metastases by Aceto, Nicola, Bardia, Aditya, Wittner, Ben S, Donaldson, Maria C, O'Keefe, Ryan, Engstrom, Amanda, Bersani, Francesca, Zheng, Yu, Comaills, Valentine, Niederhoffer, Kira, Zhu, Huili, Mackenzie, Olivia, Shioda, Toshi, Sgroi, Dennis, Kapur, Ravi, Ting, David T, Moy, Beverly, Ramaswamy, Sridhar, Toner, Mehmet, Haber, Daniel A, Maheswaran, Shyamala

“…Molecular drivers underlying bone metastases in human cancer are not well understood, in part due to constraints in bone tissue sampling. Here, RNA sequencing…”
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Expression of β-globin by cancer cells promotes cell survival during blood-borne dissemination by Zheng, Yu, Miyamoto, David T., Wittner, Ben S., Sullivan, James P., Aceto, Nicola, Jordan, Nicole Vincent, Yu, Min, Karabacak, Nezihi Murat, Comaills, Valentine, Morris, Robert, Desai, Rushil, Desai, Niyati, Emmons, Erin, Milner, John D., Lee, Richard J., Wu, Chin-Lee, Sequist, Lecia V., Haas, Wilhelm, Ting, David T., Toner, Mehmet, Ramaswamy, Sridhar, Maheswaran, Shyamala, Haber, Daniel A.

“…Metastasis-competent circulating tumour cells (CTCs) experience oxidative stress in the bloodstream, but their survival mechanisms are not well defined. Here,…”
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SETD1A protects from senescence through regulation of the mitotic gene expression program by Tajima, Ken, Matsuda, Satoru, Yae, Toshifumi, Drapkin, Benjamin J., Morris, Robert, Boukhali, Myriam, Niederhoffer, Kira, Comaills, Valentine, Dubash, Taronish, Nieman, Linda, Guo, Hongshan, Magnus, Neelima K. C., Dyson, Nick, Shioda, Toshihiro, Haas, Wilhelm, Haber, Daniel A., Maheswaran, Shyamala

“…SETD1A , a Set1 /COMPASS family member maintaining histone-H3-lysine-4 (H3K4) methylation on transcriptionally active promoters, is overexpressed in breast…”
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Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition by Comaills, Valentine, Kabeche, Lilian, Morris, Robert, Buisson, Rémi, Yu, Min, Madden, Marissa Wells, LiCausi, Joseph A., Boukhali, Myriam, Tajima, Ken, Pan, Shiwei, Aceto, Nicola, Sil, Srinjoy, Zheng, Yu, Sundaresan, Tilak, Yae, Toshifumi, Jordan, Nicole Vincent, Miyamoto, David T., Ting, David T., Ramaswamy, Sridhar, Haas, Wilhelm, Zou, Lee, Haber, Daniel A., Maheswaran, Shyamala

“…TGF-β secreted by tumor stroma induces epithelial-to-mesenchymal transition (EMT) in cancer cells, a reversible phenotype linked to cancer progression and drug…”
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NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer by Guo, Hongshan, Golczer, Gabriel, Wittner, Ben S., Langenbucher, Adam, Zachariah, Marcus, Dubash, Taronish D., Hong, Xin, Comaills, Valentine, Burr, Risa, Ebright, Richard Y., Horwitz, Elad, Vuille, Joanna A., Hajizadeh, Soroush, Wiley, Devon F., Reeves, Brittany A., Zhang, Jia-min, Niederhoffer, Kira L., Lu, Chenyue, Wesley, Benjamin, Ho, Uyen, Nieman, Linda T., Toner, Mehmet, Vasudevan, Shobha, Zou, Lee, Mostoslavsky, Raul, Maheswaran, Shyamala, Lawrence, Michael S., Haber, Daniel A.

“…Deregulation of oncogenic signals in cancer triggers replication stress. Immediate early genes (IEGs) are rapidly and transiently expressed following stressful…”
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Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses by Chiba, Naokazu, Comaills, Valentine, Shiotani, Bunsyo, Takahashi, Fumiyuki, Shimada, Toshiyuki, Tajima, Ken, Winokur, Daniel, Hayashida, Tetsu, Willers, Henning, Brachtel, Elena, Vivanco, Maria d. M, Haber, Daniel A, Zou, Lee, Maheswaran, Shyamala

“…Homeobox 9 (HOXB9), a nontransforming transcription factor overexpressed in breast cancer, alters tumor cell fate and promotes tumor progression and…”
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Effects of estrogen on the proportion of stem cells in the breast by Simões, Bruno M., Piva, Marco, Iriondo, Oihana, Comaills, Valentine, López-Ruiz, Jose A., Zabalza, Iñaki, Mieza, Jon A., Acinas, Olga, Vivanco, Maria d.M.

“…There is increasing evidence that breast cancers contain tumor-initiating cells with stem cell properties. The importance of estrogen in the development of the…”
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The metabesity factor HMG20A potentiates astrocyte survival and reactive astrogliosis preserving neuronal integrity by Lorenzo, Petra I, Martin Vazquez, Eugenia, López-Noriega, Livia, Fuente-Martín, Esther, Mellado-Gil, José M, Franco, Jaime M, Cobo-Vuilleumier, Nadia, Guerrero Martínez, José A, Romero-Zerbo, Silvana Y, Perez-Cabello, Jesús A, Rivero Canalejo, Sabrina, Campos-Caro, Antonio, Lachaud, Christian Claude, Crespo Barreda, Alejandra, Aguilar-Diosdado, Manuel, García Fuentes, Eduardo, Martin-Montalvo, Alejandro, Álvarez Dolado, Manuel, Martin, Franz, Rojo-Martinez, Gemma, Pozo, David, Bérmudez-Silva, Francisco J, Comaills, Valentine, Reyes, José C, Gauthier, Benoit R

“…We recently demonstrated that the 'Metabesity' factor HMG20A regulates islet beta-cell functional maturity and adaptation to physiological stress such as…”
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NR5A2/LRH-1 regulates the PTGS2-PGE2-PTGER1 pathway contributing to pancreatic islet survival and function by Martin Vázquez, Eugenia, Cobo-Vuilleumier, Nadia, Araujo Legido, Raquel, Marín-Cañas, Sandra, Nola, Emanuele, Dorronsoro, Akaitz, López Bermudo, Lucia, Crespo, Alejandra, Romero-Zerbo, Silvana Y., García-Fernández, Maria, Martin Montalvo, Alejandro, Rojas, Anabel, Comaills, Valentine, Bérmudez-Silva, Francisco J., Gannon, Maureen, Martin, Franz, Eizirik, Decio, Lorenzo, Petra I., Gauthier, Benoit R.

“…LRH-1/NR5A2 is implicated in islet morphogenesis postnatally, and its activation using the agonist BL001 protects islets against apoptosis, reverting…”
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Enzyme-Responsive Zr-Based Metal–Organic Frameworks for Controlled Drug Delivery: Taking Advantage of Clickable PEG-Phosphate Ligands by Carrillo-Carrión, Carolina, Comaills, Valentine, Visiga, Ana M., Gauthier, Benoit R., Khiar, Noureddine

“…We report for the first time the controlled drug release from a nanoscale Zr-based metal–organic framework (MOF), UiO-66, in the presence of the enzyme…”
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COX-2 mediates tumor-stromal prolactin signaling to initiate tumorigenesis by Zheng, Yu, Comaills, Valentine, Burr, Risa, Boulay, Gaylor, Miyamoto, David T., Wittner, Ben S., Emmons, Erin, Sil, Srinjoy, Koulopoulos, Michael W., Broderick, Katherine T., Tai, Eric, Rengarajan, Shruthi, Kulkarni, Anupriya S., Shioda, Toshi, Wu, Chin-Lee, Ramaswamy, Sridhar, Ting, David T., Toner, Mehmet, Rivera, Miguel N., Maheswaran, Shyamala, Haber, Daniel A.

“…Tumor-stromal communication within the microenvironment contributes to initiation of metastasis and may present a therapeutic opportunity. Using serial…”
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SETD1A modulates cell cycle progression through a miRNA network that regulates p53 target genes by Tajima, Ken, Yae, Toshifumi, Javaid, Sarah, Tam, Oliver, Comaills, Valentine, Morris, Robert, Wittner, Ben S., Liu, Mingzhu, Engstrom, Amanda, Takahashi, Fumiyuki, Black, Joshua C., Ramaswamy, Sridhar, Shioda, Toshihiro, Hammell, Molly, Haber, Daniel A., Whetstine, Johnathan R., Maheswaran, Shyamala

“…Expression of the p53-inducible antiproliferative gene BTG2 is suppressed in many cancers in the absence of inactivating gene mutations, suggesting alternative…”
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