Search Results - "Colwill, K."

NetworKIN: a resource for exploring cellular phosphorylation networks by Linding, Rune, Jensen, Lars Juhl, Pasculescu, Adrian, Olhovsky, Marina, Colwill, Karen, Bork, Peer, Yaffe, Michael B, Pawson, Tony

“…Protein kinases control cellular responses by phosphorylating specific substrates. Recent proteome-wide mapping of protein phosphorylation sites by mass…”
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Myxoma Virus M-T5 Protects Infected Cells from the Stress of Cell Cycle Arrest through Its Interaction with Host Cell Cullin-1 by JOHNSTON, J. B, WANG, G, BARRETT, J. W, NAZARIAN, S. H, COLWILL, K, MORAN, M, MCFADDEN, G

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Generating a panel of highly specific antibodies to 20 human SH2 domains by phage display by Pershad, K., Pavlovic, J.D., Gräslund, S., Nilsson, P., Colwill, K., Karatt-Vellatt, A., Schofield, D.J., Dyson, M.R., Pawson, T., Kay, B.K., McCafferty, J.

“…To demonstrate the utility of phage display in generating highly specific antibodies, affinity selections were conducted on 20 related Src Homology 2 (SH2)…”
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The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution by Colwill, K., Pawson, T., Andrews, B., Prasad, J., Manley, J. L., Bell, J. C., Duncan, P. I.

“…Mammalian Clk/Sty is the prototype for a family of dual specificity kinases (termed LAMMER kinases) that have been conserved in evolution, but whose…”
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A roadmap to generate renewable protein binders to the human proteome by Colwill, Karen, Gräslund, Susanne

“…A multilaboratory pilot project demonstrates that hybridoma and phage display technologies can be applied to produce high-affinity, high-specificity renewable…”
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Large-scale mapping of human protein-protein interactions by mass spectrometry by Figeys, Daniel, Ewing, Rob M, Chu, Peter, Elisma, Fred, Li, Hongyan, Taylor, Paul, Climie, Shane, McBroom-Cerajewski, Linda, Robinson, Mark D, O'Connor, Liam, Li, Michael, Taylor, Rod, Dharsee, Moyez, Ho, Yuen, Heilbut, Adrian, Moore, Lynda, Zhang, Shudong, Ornatsky, Olga, Bukhman, Yury V, Ethier, Martin, Sheng, Yinglun, Vasilescu, Julian, Abu-Farha, Mohamed, Lambert, Jean-Philippe, Duewel, Henry S, Stewart, Ian I, Kuehl, Bonnie, Hogue, Kelly, Colwill, Karen, Gladwish, Katharine, Muskat, Brenda, Kinach, Robert, Adams, Sally-Lin, Moran, Michael F, Morin, Gregg B, Topaloglou, Thodoros

“…Mapping protein–protein interactions is an invaluable tool for understanding protein function. Here, we report the first large‐scale study of protein–protein…”
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Systematic Discovery of In Vivo Phosphorylation Networks by Linding, Rune, Jensen, Lars Juhl, Ostheimer, Gerard J., van Vugt, Marcel A.T.M., Jørgensen, Claus, Miron, Ioana M., Diella, Francesca, Colwill, Karen, Taylor, Lorne, Elder, Kelly, Metalnikov, Pavel, Nguyen, Vivian, Pasculescu, Adrian, Jin, Jing, Park, Jin Gyoon, Samson, Leona D., Woodgett, James R., Russell, Robert B., Bork, Peer, Yaffe, Michael B., Pawson, Tony

“…Protein kinases control cellular decision processes by phosphorylating specific substrates. Thousands of in vivo phosphorylation sites have been identified,…”
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WW Domains Provide a Platform for the Assembly of Multiprotein Networks by Ingham, Robert J., Colwill, Karen, Howard, Caley, Dettwiler, Sabine, Lim, Caesar S. H., Yu, Joanna, Hersi, Kadija, Raaijmakers, Judith, Gish, Gerald, Mbamalu, Geraldine, Taylor, Lorne, Yeung, Benny, Vassilovski, Galina, Amin, Manish, Chen, Fu, Matskova, Liudmila, Winberg, Gösta, Ernberg, Ingemar, Linding, Rune, O'Donnell, Paul, Starostine, Andrei, Keller, Walter, Metalnikov, Pavel, Stark, Chris, Pawson, Tony

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Towards proteome scale antibody selections using phage display by Mersmann, Michael, Meier, Doris, Mersmann, Jana, Helmsing, Saskia, Nilsson, Peter, Gräslund, Susanne, Structural Genomics Consortium, Colwill, Karen, Hust, Michael, Dübel, Stefan

“…In vitro antibody generation by panning a large universal gene library with phage display was employed to generate antibodies to more than 60 different…”
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Regulation of Nucleocytoplasmic Shuttling of Bruton's Tyrosine Kinase (Btk) through a Novel SH3-Dependent Interaction with Ankyrin Repeat Domain 54 (ANKRD54) by Gustafsson, Manuela O., Hussain, Alamdar, Mohammad, Dara K., Mohamed, Abdalla J., Nguyen, Vivian, Metalnikov, Pavel, Colwill, Karen, Pawson, Tony, Smith, C. I. Edvard, Nore, Beston F.

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The Protein Kinase Clk/Sty Directly Modulates SR Protein Activity: Both Hyper- and Hypophosphorylation Inhibit Splicing by Prasad, Jayendra, Colwill, Karen, Pawson, Tony, Manley, James L.

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Characterization of the yeast amphiphysins Rvs161p and Rvs167p reveals roles for the Rvs heterodimer in vivo by Friesen, Helena, Humphries, Christine, Ho, Yuen, Schub, Oliver, Colwill, Karen, Andrews, Brenda

“…We have used comprehensive synthetic lethal screens and biochemical assays to examine the biological role of the yeast amphiphysin homologues Rvs161p and…”
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Myxoma Virus M11L Prevents Apoptosis through Constitutive Interaction with Bak by WANG, Gen, BARRETT, John W, NAZARIAN, Steven H, EVERETT, Helen, GAO, Xiujuan, BLEACKLEY, Chris, COLWILL, Karen, MORAN, Michael F, MCFADDEN, Grant

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Interaction of the Saccharomyces cerevisiae Cortical Actin Patch Protein Rvs167p With Proteins Involved in ER to Golgi Vesicle Trafficking by Friesen, Helena, Colwill, Karen, Robertson, Karen, Schub, Oliver, Andrews, Brenda

“…We have used affinity chromatography to identify two proteins that bind to the SH3 domain of the actin cytoskeleton protein Rvs167p: Gyp5p and Gyl1p. Gyp5p has…”
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SRPK1 and Clk/Sty Protein Kinases Show Distinct Substrate Specificities for Serine/Arginine-rich Splicing Factors by Colwill, K, Feng, L L, Yeakley, J M, Gish, G D, Cáceres, J F, Pawson, T, Fu, X D

“…Serine/arginine-rich (SR) proteins are essential for pre-mRNA splicing, and modify the choice of splice site during alternative splicing in a process…”
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Modification of the Creator recombination system for proteomics applications--improved expression by addition of splice sites by Colwill, Karen, Wells, Clark D, Elder, Kelly, Goudreault, Marilyn, Hersi, Kadija, Kulkarni, Sarang, Hardy, W Rod, Pawson, Tony, Morin, Gregg B

“…Recombinational systems have been developed to rapidly shuttle Open Reading Frames (ORFs) into multiple expression vectors in order to analyze the large number…”
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In vivo analysis of the domains of yeast Rvs167p suggests Rvs167p function is mediated through multiple protein interactions by Colwill, K, Field, D, Moore, L, Friesen, J, Andrews, B

“…Morphological changes during cell division in the yeast Saccharomyces cerevisiae are controlled by cell-cycle regulators. The Pcl-Pho85p kinase complex has…”
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Interaction of yeast Rvs167 and Pho85 cyclin-dependent kinase complexes may link the cell cycle to the actin cytoskeleton by Lee, Jinhwa, Colwill, Karen, Aneliunas, Vicky, Tennyson, Christine, Moore, Lynda, Ho, Yuen, Andrews, Brenda

“…Background:PHO85 encodes the catalytic subunit of a cyclin-dependent kinase (Cdk) in budding yeast and functions in phosphate and glycogen metabolism. Pho85…”
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RS cyclophilins: identification of an NK-TR1-related cyclophilin by Nestel, F P, Colwill, K, Harper, S, Pawson, T, Anderson, S K

“…We report the isolation of a large cyclophilin protein containing RS (arginine-serine) repeats from a yeast two-hybrid screen using ClK (CDC28/cdc2-like…”
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RS cyclophilins: Identification of an NK-TR sub(1)-related cyclophilin by Nestel, F P, Colwill, K, Harper, S, Pawson, T, Anderson, S K

“…We report the isolation of a large cyclophilin protein containing RS (arginine-serine) repeats from a yeast two-hybrid screen using Clk (CDC28/cdc2-like…”
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